Espasmo da artéria coronária
Revisado por Dr Colin Tidy, MRCGPÚltima atualização por Dr Hayley Willacy, FRCGP Last updated 17 Nov 2024
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Nesta série:AnginaAngina microvascular
Espasmo da artéria coronária é um estreitamento temporário e súbito de uma ou mais artérias coronárias.
At a glance
Coronary artery spasm, also called Prinzmetal's angina, is when an artery to the heart temporarily narrows.
This spasm slows or stops blood flow, reducing blood supply to the heart muscle.
Symptoms can include severe chest pain, often at rest, and sometimes shortness of breath.
Emotional stress, alcohol, cold, or certain stimulant drugs can trigger spasms.
The chest pain can last 5 to 30 minutes and may spread to the neck, jaw, shoulder, or arm.
Treatment involves avoiding triggers, lifestyle changes, and medicines such as calcium-channel blockers.
A severe, prolonged spasm can lead to a heart attack.
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What is a coronary artery spasm?
The spasm slows or stops blood flowing through the artery and so reduces the blood supply to the heart muscle. Coronary artery spasm is sometimes called variant angina or Prinzmetal's angina. Angina is a medical term for chest pain.
Symptoms of a coronary artery spasm
Voltar ao conteúdoCoronary artery spasm may occur without any symptoms. The most common symptom is heart chest pain (angina). If the coronary artery spasm is severe and lasts long enough then it may cause a heart attack (myocardial infarction).
Chest pain (angina)
With angina, the pain is usually described as:
Severe pain that can be felt under the breast bone (sternum) or on the left side of the chest.
A feeling of crushing, pressure, squeezing or tightness.
A pain that spreads to the neck, jaw, shoulder or arm. It may feel like it's in the back.
The chest pain caused by coronary artery spasm often occurs at rest and commonly doesn't occur during exercise. This is very different from angina due to fatty patches or plaques (atheroma), when the pain is usually triggered by exercise and goes away when you rest.
The chest pain may occur at the same time each day and most often occurs during the night and early morning. The pain can be very variable but usually lasts between 5 and 30 minutes. It can occasionally spread to the back. The pain does not improve with change of position, unlike pericardite, which is sometimes relieved by leaning forward.
Coronary artery spasm may also cause shortness of breath. A severe episode of coronary artery spasm may cause a loss of consciousness.
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Causes of a coronary artery spasm
Voltar ao conteúdoCoronary artery spasm often occurs in coronary arteries that have not already become blocked with fatty patches or plaques (atheroma). However, coronary artery spasm can also occur in coronary arteries that are already partially blocked with atheroma.
Coronary artery spasm may occur without any obvious cause. At other times the spasm may be triggered by various factors such as:
Estresse emocional.
Álcool.
Exposure to cold.
Stimulant drugs (such as amphetamines and cocaine).
O que mais poderia ser?
Voltar ao conteúdoCoronary artery spasm is sometimes mistaken for other heart-related (cardiac) causes of chest pain such as pericardite, a ataque cardíaco e cardiomyopathy. Non-cardiac causes of chest or upper tummy pain may need to be ruled out such as gallbladder disease e úlceras estomacais.
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How common is a coronary artery spasm?
Voltar ao conteúdoAbout 1 person in every 50 with angina has coronary artery spasm. Coronary artery spasm is more common in males and those aged between 40 and 70 years.
Coronary artery spasm is more common in people who:
Fumar.
Have high blood pressure.
Have high blood cholesterol level.
However, coronary artery spasm may occur sem any risk factors for heart disease such as fumar, diabetes, pressão alta e colesterol alto.
Diagnosing a coronary artery spasm
Voltar ao conteúdoIf you are thought to have heart chest pain (angina), you will usually be referred to see a specialist for investigations.
The initial investigations will include:
A 'heart tracing' (eletrocardiograma, ou ECG).
Other investigations may also be used, including:
The coronary angiogram may be normal if there is no blockage of the coronary arteries caused by fatty patches or plaques (atheroma). However, coronary artery spasm can be triggered by injecting a chemical into one of your veins. This is called a provocation test.
The chemical is otherwise safe and the coronary angiogram may then show temporary narrowing of the coronary arteries in people with coronary artery spasm.
Coronary artery spasm treatment
Voltar ao conteúdoThe aim of treatment is to control chest pain and to prevent a heart attack (myocardial infarction). The most important aspects of treatment are to avoid any known triggers for coronary artery spasm and to reduce the risk of heart disease. Reducing the risk of heart disease includes:
Estilo de vida advice to parar de fumar, eat a healthy diet, have regular exercise e reduce body weight if overweight.
Medicamentos may be needed, such as to control high blood pressure or a nível de colesterol alto.
See the separate leaflet called Cardiovascular disease (Atheroma).
Trinitrato de glicerilo (GTN) can be used to relieve an episode of chest pain. Your healthcare provider may prescribe other medicines to prevent chest pain. You may also need a type of medicine called a bloqueador de canais de cálcio or a long-acting nitrate. Beta-blockers should be avoided because they may make this condition worse.
You will need to be referred to a heart specialist for further investigations and treatment. Further treatments may include angioplastia coronária if you also have coronary artery blockage caused by fatty patches or plaques (atheroma).
An implantable cardioverter defibrillator may be needed if you are at risk of life-threatening abnormal heart rhythms caused by coronary artery spasm. See the separate leaflet called Abnormal heart rhythms (Arrhythmias) for more details.
Complications of a coronary artery spasm
Voltar ao conteúdoCoronary artery spasm may cause an abnormal heart rhythm (arrhythmia), which may be life-threatening. Severe and prolonged coronary artery spasm may cause a ataque cardíaco (infarto do miocárdio).
Qual é o resultado?
Voltar ao conteúdoCoronary artery spasm is a long-term condition. However, treatment most often helps to control symptoms. The outcome (prognosis) for people with coronary artery spasm is generally good if they follow treatment recommendations and avoid certain triggers.
The outcome is not as good in people who also have blockage of the coronary arteries caused by fatty patches or plaques (atheroma).
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Perguntas frequentes
Can I experience coronary artery spasm even if I don't have heart disease risk factors?
Yes, coronary artery spasm can occur even in people who do not have typical risk factors for heart disease such as smoking, diabetes, high blood pressure, and high cholesterol. However, it is more common in individuals who do have these risk factors.
How does chest pain from a coronary artery spasm differ from other types of angina?
The chest pain from a coronary artery spasm often happens when you are at rest, and usually not during exercise. This is different from angina caused by fatty plaques in the arteries, which is typically triggered by exercise and improves with rest. Pain from a spasm may also occur at the same time each day, often during the night or early morning, lasting between 5 and 30 minutes.
Are there specific times when a coronary artery spasm is more likely to occur?
Yes, the chest pain associated with coronary artery spasm frequently occurs at night and in the early morning. It may also happen at the same time each day.
What kind of tests are involved in diagnosing a coronary artery spasm?
Initial investigations for suspected angina typically include blood tests, a 'heart tracing' (ECG), and an ultrasound heart scan (echocardiogram). A coronary angiography is also common, and a 'provocation test' which involves injecting a chemical to temporarily narrow arteries, may be used to confirm coronary artery spasm.
If I am diagnosed with coronary artery spasm, will I need long-term treatment?
Yes, coronary artery spasm is considered a long-term condition. Treatment usually involves lifestyle changes, avoiding known triggers, and taking medicines to control chest pain and reduce heart disease risks. These may include glyceryl trinitrate (GTN) for immediate relief and other medications like calcium-channel blockers or long-acting nitrates to prevent pain.
Why are beta-blockers usually avoided for treating coronary artery spasm?
Beta-blockers are generally avoided in the treatment of coronary artery spasm because they may make the condition worse. Your healthcare provider will choose other suitable medications to help manage your symptoms and prevent future spasms.
Leitura adicional e referências
- Swarup S, Patibandla S, Grossman SA; Coronary Artery Vasospasm.
- Matta A, Bouisset F, Lhermusier T, et al; Coronary Artery Spasm: New Insights. J Interv Cardiol. 2020 May 14;2020:5894586. doi: 10.1155/2020/5894586. eCollection 2020.
- Teragawa H, Oshita C, Ueda T; Coronary spasm: It's common, but it's still unsolved. World J Cardiol. 2018 Nov 26;10(11):201-209. doi: 10.4330/wjc.v10.i11.201.
- Avaliando a aptidão para dirigir: guia para profissionais de saúde; Agência de Licenciamento de Motoristas e Veículos
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About the authorView full bio

Dr Hayley Willacy, FRCGP
Médico Generalista, Autor Médico
MBChB (1992), DRCOG, DFFP, MRCOG (Part 1) MRCGP (2007), DFSRH (2013), MSc - medical education (2020)
Dr Hayley Willacy was an NHS GP working in northwest England, who retired from clinical practice in 2022 after 30 years.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
Médico Generalista, Autor Médico
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy é um médico do NHS, baseado em Oxfordshire.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão prevista para: 16 Nov 2027
17 Nov 2024 | Última versão

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