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Duloxetina para sintomas urinários

Yentreve

The brand of duloxetine called Yentreve® is prescribed for women with stress incontinence. Take one capsule twice daily, in the morning and late afternoon. You may be given generic duloxetine capsules; 20 mg and 40 mg capsules are prescribed for stress incontinence.

Remember to do the exercises you have been given to strengthen your pelvic floor muscles.

Each time you collect a new supply of capsules, make sure the strength (20 mg or 40 mg) is the same as you have taken previously. If not, please speak with your pharmacist who will advise you.

At a glance

  • Duloxetine (Yentreve) treats stress incontinence in women when other treatments have not worked.

  • It helps bladder muscles contract more strongly to control urine flow.

  • Take capsules as prescribed, usually twice daily, with or without food.

  • Common side-effects include feeling sick, dry mouth, and constipation.

  • Do not stop duloxetine suddenly as it can cause problems.

  • If you have distressing thoughts or signs of serotonin syndrome, contact your doctor.

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About duloxetine for urinary symptoms

Tipo de medicamento

A serotonin and noradrenaline reuptake inhibitor

Usado para

Symptoms of stress incontinence in women

Também chamado de

Yentreve®

Disponível como

Cápsulas

Incontinência de esforço is the most common form of incontinence. It means you pass urine with things like coughing, sneezing or exercise. It happens when the pelvic floor muscles that support your bladder are weakened. Childbirth is a common reason for a weak pelvic floor. The main treatment for stress incontinence is pelvic floor exercises. Surgery to tighten or support your bladder outlet can also help.

Duloxetine may be advised if exercícios do assoalho pélvico alone are not helping to treat your stress incontinence. It is usually advised in women who do not want to undergo surgery, or in women who have health problems that may mean that surgery is unsuitable.

Duloxetine is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.

Duloxetine is also prescribed for the treatment of some mood and nerve disorders, although a different brand and strength of capsule are used. There is a separate medicine leaflet called Duloxetina para distúrbios de humor e nervosos which gives more information about duloxetine when it is used for this type of condition.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking duloxetine it is important that your doctor knows:

  • Se você está grávida, tentando ter um bebê ou amamentando.

  • Se você tiver algum problema com o funcionamento do seu fígado, ou qualquer problema com o funcionamento dos seus rins.

  • Se você tem uma condição cardíaca.

  • Se você tem pressão ocular aumentada (chamada glaucoma).

  • Se você tem pressão alta.

  • If you have ever had 'high' moods, such as mania in bipolar disorder.

  • Se você já teve uma convulsão (ataque epiléptico).

  • If you have a blood disorder that increases your risk of bleeding.

  • Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

  • Se você já teve uma reação alérgica a um medicamento.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about duloxetine and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take duloxetine exactly as your doctor tells you to. The usual dose is one 40 mg capsule twice daily (in the morning and late afternoon). If you are taking duloxetine for the first time, your doctor may give you the lower 20 mg strength capsule for a couple of weeks - this is to help avoid any unwanted symptoms when you first take duloxetine.

  • Try to take your doses at the same times of day each day, as this will help you to remember to take your doses regularly. You can take duloxetine either before or after meals. Take the capsules with a drink of water to help you to swallow.

  • Se você esquecer de tomar uma dose no horário habitual, tome-a quando se lembrar. No entanto, se estiver quase na hora de tomar a próxima dose, deixe de lado a dose esquecida e tome a próxima no horário devido. Não tome duas doses juntas para compensar uma dose esquecida.

  • Tente manter suas consultas regulares com seu médico. Isso é para que seu médico possa verificar seu progresso e revisar seu tratamento.

  • Remember to do the exercises you have been given to strengthen your pelvic floor muscles. This is important because the majority of people with stress incontinence are much improved with these exercises.

  • If you have been advised to reduce your weight, try to stick to the advice you have been given about your diet. Losing even a modest amount of weight can help to improve your symptoms.

  • Smoking can cause coughing which can aggravate your symptoms. It would help to not smoke. If you are a smoker and you need help to quit, ask your doctor or pharmacist for advice.

  • Drinking alcohol can increase the risk of unwanted effects from duloxetine, such as dizziness and blurred vision.

  • If you buy any medicines, check with a pharmacist that they are suitable to take with duloxetine. This is because some herbal medicines (such as St John's wort) can increase the chance that you will experience unwanted effects.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking duloxetine.

  • Keep taking duloxetine until your doctor tells you otherwise. Stopping suddenly can cause problems and your doctor may want you to reduce your dose gradually when this becomes necessary.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the common ones associated with duloxetine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common duloxetine side-effects (these affect more than 1 in 10 people)

O que posso fazer se passar por isso?

Sentindo-se enjoado (náusea)

Coma refeições simples - evite alimentos ricos ou picantes

Boca seca

Tente mascar chiclete sem açúcar ou chupar balas sem açúcar

Constipação

Tente manter uma dieta equilibrada e beba vários copos de água todos os dias

Common duloxetine side-effects (these affect fewer than 1 in 10 people)

O que posso fazer se passar por isso?

Blurred vision, feeling tired, dizzy or sleepy

Do not drive and do not use tools or machines while affected. Avoid alcohol

Diarreia

Beba bastante água para repor os líquidos perdidos

Dor de cabeça

Ensure you are drinking the recommended amount of fluids each day. Ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know

Lack of appetite, indigestion, stomach pain, flushing, increased blood pressure, difficulty sleeping, feeling anxious, skin tinglings, feeling shaky, reduced interest in sex, increased sweating

Discuta isso com seu médico se algum se tornar problemático

Importante: if you develop any depressing or distressing thoughts or ideas, you should let your doctor know about this as soon as possible. When this medicine is prescribed for people with depression or anxiety, it can increase the risk of suicidal thoughts, particularly when the treatment is first started.

On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking another medicine with this effect (such as an antidepressant). Seek medical attention if you develop any combination of the following:

  • Músculos rígidos ou movimentos 'sacudidos'.

  • Batimento cardíaco anormalmente rápido.

  • Temperatura alta (febre).

  • Feeling sick (nausea) or being sick (vomiting), diarrhoea.

  • Sentindo-se delirante ou vendo visões (alucinando).

Se você sentir quaisquer outros sintomas que acha que podem ser devido às cápsulas, por favor, fale com seu médico ou farmacêutico para mais orientações.

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

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Perguntas frequentes

How long will I need to take duloxetine for stress incontinence?

You should continue to take duloxetine for as long as your doctor advises. Stopping the medication suddenly can cause problems, so your doctor will likely want you to reduce your dose gradually when it's time to stop.

What should I do if I forget to take a dose of duloxetine?

If you forget a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and just take your next dose as usual. Do not take a double dose to make up for a forgotten one.

Can I drink alcohol while taking duloxetine?

Drinking alcohol can increase the risk of experiencing unwanted side-effects from duloxetine, such as dizziness and blurred vision. It's best to avoid alcohol if possible while on this medication.

Are there any over-the-counter medicines or herbal remedies I should avoid while taking duloxetine?

Yes, some medicines, including certain herbal remedies like St John's wort, can increase the chance of experiencing unwanted effects when taken with duloxetine. Always check with a pharmacist before buying any new medicines.

What is Serotonin Syndrome and what should I do if I think I have it?

Serotonin syndrome is a rare condition where the level of serotonin in the brain becomes too high. This can be more likely if you're taking another medicine that affects serotonin. Seek medical attention immediately if you develop symptoms such as stiff or jerky muscles, unusually fast heartbeat, high temperature, feeling sick or being sick, diarrhoea, feeling delirious, or seeing visions.

Will duloxetine definitely cure my stress incontinence?

Duloxetine helps the muscles around the bladder outlet contract more strongly to control urine flow and prevent leakage, especially when pelvic floor exercises alone aren't enough. It's often advised for women who don't want surgery or for whom surgery isn't suitable. Remember to continue your pelvic floor exercises as they significantly help most people with stress incontinence.

Leitura adicional e referências

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • Próxima revisão agendada: 24 de agosto de 2027
  • 23 Ago 2024 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani
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