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Injeção de Olanzapina de longa duração

Zypadhera

Olanzapine long-acting injection will be given to you by your clinic doctor or nurse every 2-4 weeks.

The injection may cause you to feel sleepy or dizzy for a few hours afterwards.

If you miss an appointment for an injection, make another appointment as soon as possible.

There are a number of side-effects which you could experience from the treatment. If you are concerned about any, you should discuss them with your doctor.

At a glance

  • Olanzapine long-acting injection is an antipsychotic medicine given for schizophrenia and similar mental health problems.

  • It is a 'depot' injection given every two or four weeks, releasing olanzapine slowly into your body.

  • You will be observed for at least three hours after each injection, as it can cause tiredness or dizziness.

  • You must tell your doctor about existing health conditions or other medicines you are taking.

  • Common side-effects include tiredness, dizziness, and weight gain.

  • Seek medical help immediately if you experience muscle stiffness, high temperature, confusion, or a fast heartbeat.

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About olanzapine long-acting injection

Tipo de medicamento

An antipsychotic injection

Usado para

Maintenance of symptom control in adults with schizophrenia and other similar mental health problems

Também chamado de

Zypadhera® (olanzapine embonate)

Disponível como

Long-acting depot injection

Olanzapine belongs to a group of medicines called antipsicóticos. You will have been prescribed it to maintain symptom control of esquizofrenia.

Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs, feeling unusually suspicious, and becoming withdrawn. Olanzapine is used to relieve the symptoms of schizophrenia and other similar mental health problems. It works on the balance of chemical substances in your brain.

Long-acting, or 'depot', injections are used once your symptoms have been eased by taking tablets. The injection slowly releases olanzapine into your body and is given either every two weeks, or every four weeks. The main advantage of a depot injection is that you do not have to remember to take tablets every day.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start having olanzapine long-acting injections, it is important that your doctor knows:

  • Se você está grávida ou amamentando.

  • Se você tem uma condição cardíaca ou doença dos vasos sanguíneos.

  • Se você tiver algum problema com o funcionamento do seu fígado, ou se tiver algum problema com o funcionamento dos seus rins.

  • Se você tiver problemas de próstata.

  • Se você tiver algum problema com a sua respiração.

  • If you have any of the following: epilepsia, diabetes (diabetes mellitus), depressão, Doença de Parkinson, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called myasthenia gravis.

  • If you have ever had yellowing of your skin or the whites of your eyes (icterícia).

  • Se você tem um distúrbio no sangue ou na medula óssea.

  • Se você estiver muito constipado ou achar que pode ter uma obstrução no intestino.

  • Se você teve uma reação alérgica a um medicamento.

  • Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

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  • Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about olanzapine, and it will also provide you with a full list of the side-effects which you could experience.

  • Olanzapine long-acting injection will be given to you in an outpatient clinic by a doctor or nurse. The injection is given into a muscle in your bottom (buttocks). As a routine, you will be asked to stay in the clinic where you can be observed for at least three hours after each injection. This is because it can make you feel tired or dizzy after it is given. You will be advised not to drive and not to use tools or machines for the remainder of the day.

  • You may be asked to continue taking your current tablets for a short while after you have had your first injection. This is because it can take a few weeks before you feel the full effect from the injection.

  • Treatment with olanzapine is usually long-term so that your symptoms don't return.

  • Your treatment will require careful monitoring to make sure that you get the best possible benefit from olanzapine. Keep your regular doctor's appointments so that you get your injections on time, and your progress can be checked. If you miss an appointment for an injection, contact the hospital to arrange for another appointment as soon as possible.

  • Olanzapine could cause your skin to become more sensitive to sunlight than normal. Avoid strong sunlight and sunbeds, and use a sun cream with a high sun protection factor even on bright but cloudy days.

  • If you drink alcohol, ask your doctor for advice about drinking while you are on olanzapine. Alcohol can increase the chance that you will experience side-effects and may not be advisable for you.

  • If you have diabetes you may need to check your blood sugar (glucose) more frequently, as olanzapine can affect the levels of sugar in your blood. Your doctor will advise you about this.

  • If you are having any dental treatment or an operation, tell the person carrying out the treatment that you have had an olanzapine injection. This is important because it may interfere with the anaesthetic you receive.

  • If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with olanzapine.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with olanzapine. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Efeitos colaterais muito comuns da olanzapina (que afetam mais de 1 em 10 pessoas)


O que posso fazer se passar por isso?

Feeling sleepy, tired or dizzy

Não dirija e não use ferramentas ou máquinas enquanto estiver afetado

Aumento de peso

Eat a well-balanced diet. Speak with your doctor if your weight becomes troublesome

Alterações em alguns resultados de exames de sangue

Seu médico irá monitorar estes

Common olanzapine side-effects

(estes afetam menos de 1 em cada 10 pessoas)

O que posso fazer se passar por isso?

Feeling restless

Converse com seu médico sobre isso

Dor no local da injeção

This should not last long. If the area becomes red, swollen or 'lumpy', let your doctor know

Boca seca

Tente mascar chiclete sem açúcar ou chupar balas sem açúcar

Constipação

Drink plenty of water, and eat a well-balanced diet containing plenty of fruit, vegetables, and fibre

Unusual or uncontrollable muscle movements, shakiness

Converse com seu médico sobre isso

Increased appetite and weight, rash, feeling hot, reduced interest in sex, erectile dysfunction, aches and pains

Discuta isso com seu médico se algum se tornar problemático

Importante: if you experience symptoms such as muscle stiffness, a very high temperature, feeling confused or sweaty, a fast heartbeat, and urinary incontinence, you should contact your doctor immediately. These can be signs of a rare but serious condition known as neuroleptic malignant syndrome.

Se você sentir quaisquer outros sintomas que acha que podem ser devido à injeção, fale com seu médico ou farmacêutico para mais orientações.

Informações importantes sobre todos os medicamentos

If you suspect that you have had an overdose of this medicine, go to the accident and emergency department of your local hospital at once.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

verificador de sintomas

Inseguro sobre misturar medicamentos?

Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.

Perguntas frequentes

What is the purpose of the long-acting injection compared to taking olanzapine tablets?

The long-acting injection of olanzapine (also known as a 'depot' injection) is used after your schizophrenia symptoms have been initially managed with tablets. Its main benefit is that you don't have to remember to take tablets every day, as the injection slowly releases the medicine into your body, either every two or four weeks.

Are there any immediate effects or precautions I should be aware of right after receiving the injection?

Yes, after each injection, you will need to stay at the clinic for at least three hours so that you can be observed. This is because the injection can make you feel tired or dizzy. For the rest of that day, you should not drive or use tools or machines.

How long does it take for the olanzapine long-acting injection to start working effectively?

It can take a few weeks before you feel the full effect from the olanzapine long-acting injection. Because of this, your doctor might ask you to keep taking your current tablets for a short time after your first injection.

What should I do if I forget or miss an appointment for my olanzapine injection?

If you miss an appointment for your injection, it's important to contact the hospital as soon as possible to arrange another appointment. Regular injections are crucial to make sure your treatment is effective and your symptoms don't return.

Can olanzapine long-acting injection affect my blood sugar, and what should I do if I have diabetes?

Yes, olanzapine can affect your blood sugar levels. If you have diabetes, you may need to check your blood sugar (glucose) more often. Your doctor will provide specific advice on how to manage this while on the medication.

What should I do if I develop muscle stiffness, a high temperature, or feel confused after my injection?

These symptoms, along with feeling sweaty, having a fast heartbeat, and urinary incontinence, can be signs of a rare but serious condition called neuroleptic malignant syndrome. If you experience these, you should contact your doctor immediately.

Leitura adicional e referências

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About the authorView full bio

Author image

Helen Allen, MPharm

Pharmacist, Medical Author

MPharm

Helen Allen qualified as a Pharmacist in 1979 and spent 3 years as the drug information leaflets' author for EMIS.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

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