Midodrina para hipotensão postural
Bramox
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 15 Abr 2023
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Taking midodrine will raise your blood pressure to help stop you feeling dizzy or faint. To begin with you will need to be monitored closely to make sure your blood pressure doesn't go too high.
Do not take a dose of midodrine too late in the evening - your last dose of the day should be taken at least four hours before your bedtime.
While being treated with midodrine, try to keep your head raised slightly when lying down in bed, for instance by using extra pillows. This helps to reduce the risk of having high blood pressure when lying down.
Em resumo
Midodrine is a medicine used to treat low blood pressure when standing up.
It helps prevent dizziness, faintness, or falls caused by postural hypotension.
You typically take it three times a day, but not late in the evening.
Your doctor will check your blood pressure regularly while you are taking it.
Possible side-effects include pain when passing urine, goosebumps, or itchy scalp.
Tell your doctor if you experience chest pain, headaches, or blurred vision.
About midodrine
Tipo de medicamento | An alpha-adrenergic sympathomimetic medicine (alpha-agonist) |
Usado para | Postural hypotension (low blood pressure when standing) due to autonomic nervous system dysfunction |
Também chamado de | Bramox® |
Disponível como | Comprimidos |
Midodrine is used to treat the problem of having low blood pressure when standing up from a sitting position or when already standing. This condition is known as postural hypotension, or alternatively, orthostatic hypotension. A drop in your blood pressure when you stand up can make you feel dizzy and light-headed, or cause you to faint. This can also put you at risk of falling over. Other symptoms include blurred vision, weakness or tiredness (fatigue), feeling sick (nausea) a fast heartbeat (palpitations) and headaches.
Postural hypotension can have a number of underlying causes. It may be caused by taking certain medicines or if you become lacking in fluid in the body (dehydrated) due to being sick (vomiting) or having diarrhoea. If this is the case, standing up slowly or sitting upright first before standing may help to manage your symptoms. Postural hypotension may also be caused by an underlying problem with your nervous system such as Doença de Parkinson ou neuropatia periférica.
Midodrine is used when severe symptoms are being caused by a problem with your nervous system and other forms of treatment have not helped. It works by stimulating certain parts of your nervous system (alpha receptors) which has the effect of narrowing your blood vessels. As your blood vessels narrow, your blood pressure goes up. This helps stop any dizziness or fainting when you stand up.
Before taking midodrine tablets
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking midodrine it is important that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
Se você tem pressão alta (hipertensão).
If you have been told you have a disorder of the nervous system.
If you have a heart condition or any problems with your blood vessels.
If you have any problems with your prostate gland or if you have difficulty passing urine.
If you have any problems with the way your kidneys or liver work.
If you have glaucoma, a condition which causes raised pressure in the eye(s).
If you have diabetes mellitus, a condition which raises your blood sugar levels. In particular, if your diabetes has caused any problems with your vision.
Se você tem uma glândula tireoide hiperativa (hipertireoidismo).
Se você tiver um tumor na glândula adrenal, chamado feocromocitoma.
Se você já teve uma reação alérgica a um medicamento.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
How to take midodrine tablets
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about midodrine and a full list of side-effects which you may experience from taking it.
Take midodrine exactly as your doctor tells you to. Your dose will be written on the label of your pack to remind you.
The usual starting dose is one 2.5 mg tablet taken three times a day. Your blood pressure will need to be monitored and your dose may be increased each week until you find the lowest dose that controls your blood pressure. The maximum dose is 10 mg three times a day.
Swallow the tablets with a drink of water. It is not important whether you take your dose before or after food.
Do not take a dose of midodrine late in the evening, take your last dose of the day at least four hours before your bedtime.
If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose or unless it is within four hours of your bedtime. In these cases leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Obtendo o máximo do seu tratamento
Tente manter todas as suas consultas regulares com o seu médico. Isso é para que o seu médico possa verificar o seu progresso.
Your blood pressure may need to be monitored when you are lying down and when you are standing up. This is to make sure your blood pressure does not go too high when you are lying down. If your blood pressure does go up when you are lying down then your dose of midodrine may need to be reduced.
You may find it useful to have a blood pressure meter to use at home. Ask your doctor or pharmacist for advice about testing your blood pressure at home.
When you are lying down in bed try to keep your head raised - for instance, by using extra pillows. This is to help prevent your blood pressure going too high when you are lying down.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking midodrine.
If you buy any medicines, check with your doctor or a pharmacist that they are suitable for you to take with midodrine.
Can midodrine tablets cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with midodrine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common midodrine side-effects (these affect more than 1 in 10 people) | O que posso fazer se passar por isso? |
Pain when passing urine | Informe seu médico sobre isso |
Goosebumps, itchy scalp | If either of these become troublesome, let your doctor know |
Common midodrine side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Feeling sick (nausea), indigestion or heartburn (reflux) | Mantenha-se em refeições simples - evite alimentos ricos ou picantes |
Raised blood pressure when lying down | Using a blood pressure meter at home may help to identify this. Let your doctor know if you have any concerns |
Dor de cabeça | Let your doctor know if you experience repeated headaches, especially if you also have blurred vision (see below) |
Dificuldade para urinar | Informe seu médico sobre isso |
Chills, tingling or itchy skin, skin flushing, skin rash, swollen or painful lining of the mouth | If any of these become troublesome let your doctor know |
Importante: taking midodrine may cause your blood pressure to go too high. This can be a particular problem if it happens when you are lying down. Your dose may need to be reduced or your treatment stopped. Your doctor will monitor your blood pressure and it may also help to use a blood pressure meter at home.
Let your doctor know if you think your blood pressure is too high or if you experience symptoms such as:
Dor no peito
A fast heartbeat (palpitations)
Falta de ar
Dores de cabeça
Visão embaçada
Se você sentir quaisquer outros sintomas que acha que podem ser devido a este medicamento, fale com seu médico ou farmacêutico.
How to store midodrine tablets
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Midodrine tablets that are packaged in a bottle must be used within eight weeks of opening the bottle.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
Can midodrine cause fatigue?
The article mentions that postural hypotension, the condition midodrine treats, can cause weakness or tiredness (fatigue). However, fatigue is not listed as a side-effect of midodrine itself.
Does midodrine cause sleepiness?
Sleepiness is not listed as a common or very common side-effect of midodrine in the provided article. The article does mention, however, that your last dose of the day should be taken at least four hours before bedtime, to avoid your blood pressure going too high when lying down.
How long does midodrine take to work?
The article states that your dose of midodrine may be increased each week until the lowest dose that controls your blood pressure is found. This implies that the full therapeutic effect might take some time as the dosage is adjusted.
Are there specific times of day I should avoid taking midodrine?
Yes, you should not take a dose of midodrine late in the evening. Your last dose of the day should be taken at least four hours before your bedtime to prevent your blood pressure from becoming too high while you are lying down.
Leitura adicional e referências
- Manufacturer's PIL, Bramox® 2.5 mg, 5 mg and 10 mg tablets; Brancaster Pharma Ltd, The electronic Medicines Compendium. Dated December 2021.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão prevista para: 13 de outubro de 2027
15 Abr 2023 | Última versão
3 May 2017 | Publicado originalmente
Escrito por:
Michael Stewart, MRPharmS

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