Toxina botulínica tipo A para enxaqueca
Botox
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 19 Set 2023
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Botulinum toxin type A is a specialist treatment for migraine.
To be eligible for this treatment you must have headaches for 15 or more days each month, with migraine headaches being on at least eight of these days.
It will be given by multiple injections into the muscles around your head and neck.
If you experience any difficulty swallowing, speaking, or breathing after the treatment, speak with your doctor immediately.
Em resumo
Botulinum toxin type A is a neurotoxin used to prevent chronic migraine headaches.
It is given by injection into muscles around the head and neck.
To be eligible, you must have frequent headaches and have tried other migraine prevention medicines.
Injections are typically repeated every 12 weeks if the treatment is successful.
Common side-effects include pain at injection sites and muscle pain or weakness.
Seek immediate medical help if you experience difficulty swallowing, speaking, or breathing.
About botulinum toxin type A
Tipo de medicamento | A bacterial neurotoxin |
Usado para | To prevent headaches associated with chronic migraine in adults |
Também chamado de | Onabotulinumtoxin A (in US); Alluzience®; Azzalure®; Bocouture®; Botox®; Nuceiva®; Xeomin® |
Disponível como | Injeção |
Botulinum toxin type A is a protein substance which is produced by the bacterium Clostridium botulinum. It is a neurotoxin which means that it interferes with the way nerves work. To be eligible for this treatment you must have headaches for 15 or more days each month, with migraine headaches being on at least eight of these days. You must also have tried several other medicines to prevent migraine before this treatment is prescribed for you.
Botulinum toxin type A is thought to work in chronic migraine by relaxing muscles and by blocking the pain signals which are involved in the development of a migraine. These actions may have the effect of stopping a migraine headache from being triggered.
Botulinum toxin injections are also used for other reasons (including cosmetic purposes, muscle spasms, bladder problems, and excessive sweating). This leaflet does not cover the use of botulinum toxin type A in these ways.
Before being treated with botulinum toxin type A
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before being treated with botulinum toxin type A for migraine, make sure that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
If you have an infection or any swelling near any of the areas that will be injected.
If you have any muscle problems, particularly any muscle weakness.
If you have ever had any difficulty in swallowing or with your breathing.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
How you will be given botulinum toxin type A
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about Botox® and will provide you with a full list of the side-effects which you may experience from having it.
You will be given botulinum toxin type A by a doctor who is trained in the use of this treatment. It will be injected into the muscles around your head and neck in several different places.
If the treatment proves successful for you, your doctor is likely to recommend that it is repeated every 12 weeks.
Obtendo o máximo do seu tratamento
If you are having an operation or dental treatment, tell the person carrying out the treatment that you have received botulinum toxin type A.
Can botulinum toxin type A cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with botulinum toxin type A. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects may occur following a treatment session even if you have been free from side-effects on previous treatments. You should speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common Botox® side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Pain at the sites where you have been injected, neck and muscle pain or stiffness, muscle weakness, skin rash and itching | These should soon pass, but if any becomes troublesome, speak with your doctor |
Worsening of headache or migraine | Converse com seu médico sobre isso |
Eyelid drooping or swelling, paralysis of the face | Converse com seu médico sobre isso |
Importante: if you experience any difficulty swallowing, speaking, or breathing, speak with your doctor immediately or go to your local accident and emergency department straightaway.
If you experience any other symptoms which you think may be due to the treatment, speak with your doctor or pharmacist for further advice.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
If you buy any medicines, check with a pharmacist that they are safe to use alongside this treatment.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is botulinum toxin type A and how does it relate to Botox®?
Botulinum toxin type A is a protein substance derived from a bacterium which primarily interferes with nerve function. Botox® is one of several brand names, alongside others like Alluzience®, Azzalure®, Bocouture®, and Xeomin®, under which botulinum toxin type A is available for medical treatments, including chronic migraine.
Are there specific criteria I need to meet to be eligible for botulinum toxin type A treatment for migraine?
Yes, to be eligible for this treatment for migraine, you must experience headaches for 15 or more days each month, with migraine headaches occurring on at least eight of those days. Additionally, you need to have attempted and found insufficient several other migraine prevention medicines before this treatment will be considered.
How often will I need to receive botulinum toxin type A injections if they are effective for my migraines?
If the treatment is successful in managing your chronic migraines, your doctor will likely recommend that the injections are repeated approximately every 12 weeks.
Are there any specific situations where I should inform other healthcare professionals about my botulinum toxin type A treatment?
Yes, if you are planning to have an operation or dental treatment, it is important to inform the person carrying out the procedure that you have received botulinum toxin type A injections.
What should I do if I experience rare but serious side effects like difficulty swallowing or breathing after treatment?
If you experience any serious side effects such as difficulty swallowing, speaking, or breathing, you should seek immediate medical attention. Contact your doctor straightaway or go directly to your local accident and emergency department.
Leitura adicional e referências
- Folheto Informativo do Fabricante, Botox® 50, 100 e 200 Unidades Allergan; AbbVie Ltd, O Compêndio Eletrônico de Medicamentos. Datado de abril de 2023.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão prevista para: 18 de setembro de 2026
19 Set 2023 | Última versão

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