complement C3
Última atualização 18 de ago de 2020
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A C3 gene provides instructions for making a protein called complement component 3 (or C3). This protein plays a key role in a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues.
Normal function
A C3 gene provides instructions for making a protein called complement component 3 (or C3). This protein plays a key role in a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues.
The C3 protein is essential for turning on (activating) the complement system. The presence of foreign invaders triggers the C3 protein to be cut (cleaved) into two smaller pieces. One of these pieces, called C3b, interacts with several other proteins on the surface of cells to trigger the complement system's response. This process must be carefully regulated so the complement system targets only unwanted materials and does not damage the body's healthy cells.
Researchers have identified two major forms (allotypes) of the C3 protein, which are known as C3S and C3F. In the general population, C3S is more common than C3F. The two allotypes differ by a single protein building block (amino acid), although it is unclear whether they function differently.
Conditions referring to this gene or chromosome
Other names
acylation-stimulating protein cleavage product
AHUS5
ARMD9
ASP
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
C3a
C3b
CO3_HUMAN
complement component 3
CPAMD1
Related patient information and medicines
Patient information leaflet
Vacina meningocócica para meningite
Meningite is a serious disease which can be fatal, particularly for babies and children. ...ent meningococcal disease: One type of vaccine protects against group C only - the MenC vaccine (NeisVac-C® and Menjugate Kit®) A combined conjugate vaccine is also available which protects against group C and another bacteria called Haemophilus.
Patient information leaflet
Medicina complementar e alternativa
Side-effects: Although CAMs may seem more natural and holistic than most conventional medicine, CAMs can also cause serious side-effects, are often not effective in treating symptoms,. How effective is complementary and alternative medicine. Types of complementary e alternative medicine Manipulation the... Regulation: A Medicamentos and.
Patient information leaflet
Transtorno dissociativo de identidade
Whilst it is not certain what causes dissociative identity disorder. The trauma affects how the child's mind develops, causing DID symptoms in adulthood. What is trauma. Trauma occurs when an overwhelming event leaves a person feeling helpless. The event can be physical, sexual or emotional in nature. The traumatic feelings are too great for the.
Patient information leaflet
Neuralgia pós-herpética
Sleep disorder. Many people find that their sleep is disturbed. Depression. Having this pain can lead to symptoms of depression occurring in some people. Postherpetic neuralgia treatment Postherpetic neuralgia is not like other pains, such as headaches or toothache. The pain is caused by the nerve endings which were affected by the shingles. These.
Patient information leaflet
Dor neuropática
Capsaicin cream should not be applied to broken or inflamed skin. Hands should always be washed immediately after applying capsaicin cream. Editor's Note Dr Krishna Vakharia , 11th July 2024 Whilst capsaicin cream has been shown to be helpful- at this current time there are no supplies of the medication in the UK. It is unknown when these items.
Patient information leaflet
Lúpus
Lúpus is the short name for the condition called lúpus eritematoso sistêmico (LES).
Leitura adicional e referências
- complement C3; MedlinePlus, National Library of Medicine.
- Martinez-Barricarte R, Heurich M, Valdes-Canedo F, Vazquez-Martul E, Torreira E, Montes T, Tortajada A, Pinto S, Lopez-Trascasa M, Morgan BP, Llorca O, Harris CL, Rodriguez de Cordoba S. Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation. J Clin Invest. 2010 Oct;120(10):3702-12. doi: 10.1172/JCI43343. Epub 2010 Sep 13.
- Okura Y, Kobayashi I, Yamada M, Sasaki S, Yamada Y, Kamioka I, Kanai R, Takahashi Y, Ariga T. Clinical characteristics and genotype-phenotype correlations in C3 deficiency. J Allergy Clin Immunol. 2016 Feb;137(2):640-644.e1. doi: 10.1016/j.jaci.2015.08.017. Epub 2015 Oct 4. No abstract available.
- Xiao X, Pickering MC, Smith RJ. C3 glomerulopathy: the genetic and clinical findings in dense deposit disease and C3 glomerulonephritis. Semin Thromb Hemost. 2014 Jun;40(4):465-71. doi: 10.1055/s-0034-1376334. Epub 2014 May 5.
- Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Cordoba SR, Noris M, Pickering M, Smith R. The role of complement in C3 glomerulopathy. Mol Immunol. 2015 Sep;67(1):21-30. doi: 10.1016/j.molimm.2015.03.012. Epub 2015 Apr 28.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.