Mastoidite

What is mastoiditis?

The mastoid process is an inferior extension of the petrous temporal bone of the skull and provides a structural function as an anchor point for the large muscles of the neck. It contains multiple air cells that develop from a single main cavity (the antrum), after the age of about 2 years. In cross-section, it has a vacuolated or honeycomb appearance.

The tympanic cavity of the middle ear is in communication with the mastoid antrum via a small canal that runs through the petrous temporal bone. The mastoid air cells are related superiorly to the middle cranial fossa and posteriorly to the posterior cranial fossa. This means that suppuration in the mastoid may, rarely, spread to cause meningitis or a cerebral abscess. Other surrounding structures include the facial nerve canal, the sigmoid sinus and the lateral sinus.

Mastoiditis occurs when suppurative infection extends from a middle ear affected by otitis media to the mastoid air cells. The infective process causes inflammation of the mastoid and surrounding tissues and may lead to bony destruction.

• Classic, or acute, mastoiditis is a rare complication of acute otitis media (AOM).

• Acute mastoiditis is defined as an acute inflammation of the mastoid with colliquation of the air-filled mastoidal bone.¹

• Subacute mastoiditis is caused by persistent middle ear infection or recurrent episodes of acute otitis media with inadequate antimicrobial therapy.² This leads to persistent infection of the middle ear and mastoid air cells resulting in erosion of boney septations between mastoid air cells. It presents in a chronic, or subclinical, fashion. It is usually associated with chronic suppurative otitis media or cholesteatoma.

Otite média (OM) é um termo abrangente para um grupo de condições infecciosas e inflamatórias complexas que afetam o ouvido médio. Toda OM envolve patologia do ouvido médio e da mucosa do ouvido médio. A OM é uma das principais causas de visitas a serviços de saúde em todo o mundo e suas complicações são causas importantes de perda auditiva evitável, particularmente no mundo em desenvolvimento.⁵

Existem vários subtipos de OM. Estes incluem AOM, otitis media with effusion (OME), otite média supurativa crônica (OMSC), mastoiditis and colesteatoma. Elas são geralmente descritas como doenças distintas, mas na realidade há um grande grau de sobreposição entre os diferentes tipos. OM pode ser vista como um contínuo/espectro de doenças.

• AOM is acute inflammation of the middle ear and may be caused by bacteria or viruses. A subtype of AOM is acute suppurative OM, characterised by the presence of pus in the middle ear. In around 5% the eardrum perforates.

• OME é uma condição inflamatória crônica sem inflamação aguda, que muitas vezes segue uma OMA que se resolve lentamente. Há um derrame de fluido semelhante a cola atrás de uma membrana timpânica intacta na ausência de sinais e sintomas de inflamação aguda.

• CSOM é uma inflamação supurativa crônica do ouvido médio, geralmente com uma membrana timpânica persistentemente perfurada.

• Mastoidite é uma inflamação aguda do periósteo mastoide e das células aéreas que ocorre quando a infecção por OMA se espalha a partir do ouvido médio.

• O colesteatoma ocorre quando o epitélio escamoso queratinizante (pele) está presente no ouvido médio como resultado da retração da membrana timpânica.

• Mastoiditis in acute or chronic form is quite rare.

• It involves about 1/400 cases (0.24%) of AOM, with an incidence varying from 1.2 to 6.1 per 100,000 children aged 0–14 years and a peak occurring at 2–3 years.⁶⁷

• The COVID‐19 pandemic led to a significant change in the presentation and case mix of acute paediatric mastoiditis in the UK, with fewer cases overall, a loss of the usual winter peak and a change in the affected population.⁸

• The in-hospital incidence of mastoiditis increased significantly post-pandemic compared to the period before the pandemic (mastoiditis: 5.5 vs. 13.6 per 1000 admissions).⁹

Risk factors for mastoiditis²

• Cochlear implants; the incidence of mastoiditis in one cochlear implant cohort was 1.7 %, with a mean age at the time of AM diagnosis of 45.9 months. Most cases occurred within the first year after CI surgery, with Streptococcus pneumoniae, Streptococcus pyogenes, and Haemophilus influenzae identified as the most common pathogens.¹⁰

• Patients with immunocompromise may be more prone to mastoiditis.

• Children or adults with intellectual impairment or communication difficulties are thought to be susceptible to the condition, possibly as a result of not being able to communicate their symptoms.

• Pre-existence of cholesteatoma is a risk factor for subsequent mastoiditis.

• Streptococcus pneumoniae (most frequently isolated).

• Streptococcus pyogenes.

• Staphylococcus spp.

• Haemophilus influenzae (this is quite rare).

• Pseudomonas aeruginosa (becoming increasingly common).

• Moraxella catarrhalis.

• Other Gram-negative organisms (occur more frequently in chronic form).

• Mycobacteria (rare).

• Aspergillus and other fungi (rare).

Early diagnosis and prompt treatment are important to reduce the risk of complications.¹¹

Acute (classic) mastoiditis¹²

• History of acute or recurrent episodes of otitis media.

• Intense otalgia and pain behind the ear.

• Febre.

• Infants may present with irritability, intractable crying and feeding problems.

• Swelling, redness or a boggy, tender mass behind the ear.

• The external ear may protrude forwards; fluctuance can sometimes be demonstrated behind the ear (examine from behind).

• Ear discharge may be present and the eardrum may be perforated.

• Tympanic membrane bulges and is erythematous.

• The patient is unwell.

Subacute mastoiditis²

• Presents in a subtle or subclinical fashion after an episode of AOM or with history of chronic suppurative otitis media.

• Recurrent bouts of otalgia and retro-aural pain.

• Recurrent headache.

• Episodes of fever.

• Infants may present with irritability, intractable crying and feeding problems.

• Tympanic membrane may appear infected or may be normal.

• May be no external evidence of peri-mastoid inflammation.

Other points on examination

• Examine for evidence of local neurological involvement. There may be an ipsilateral VIth or VIIth cranial nerve palsy, or pain over the distribution of the ophthalmic division of the Vth cranial nerve.

• The patient may complain of deafness and there may be signs of conductive deafness (Rinne's test negative; Weber's test - sound localised/loudest in the affected ear).

• Otite média ou externa.

• Trauma to the ear/mastoid.

• Cervical lymph node enlargement.

• Meningite.

• Celulite.

• Parotid swelling.

• Bone cysts or tumours.

• Basal skull fracture.

• Other source of intracranial or localised sepsis.

• Febre de origem desconhecida.

• FBC may show leukocytosis.

• ESR and CRP may be elevated.

• Blood cultures should be taken.

• Fluid can be extracted from the middle ear through perforated drums or by intervention (tympanocentesis) and should be sent for Gram staining, culture and acid-fast stain.

• Skull X-ray of the mastoid area is not usually helpful but may show clouding of mastoid air cells.

• CT and/or MRI scanning can be used to aid diagnosis and look for intracranial complications.¹³

• Lumbar puncture should be carried out if intracranial spread is suspected.

• Audiograms during and after mastoiditis help to quantify and monitor any associated hearing loss.

• Patients with suspected mastoiditis should usually be managed in a hospital setting.¹⁶

• Appropriate clinical suspicion and prompt diagnosis are important to reduce the likelihood of complications.

• The usual initial therapy is high-dose, broad-spectrum intravenous (IV) antibiotics, given for at least 1-2 days (eg, a third-generation cephalosporin and metronidazole), according to local sensitivities.

• Oral antibiotics are usually used after this, starting on IV treatment after 48 hours without fever and continuing for at least 1-2 weeks.

• Paracetamol, ibuprofen and other agents may be given as antipyretics and/or painkillers.

• Myringotomy ± tympanostomy tube insertion may be performed in some cases as a therapeutic procedure, or to collect middle ear fluid for culture.

• Immediate mastoidectomy is usually the method of choice to treat acute mastoiditis with subperiosteal abscess formation.¹

• Surgical intervention, usually in the form of mastoidectomy ± tympanoplasty, is also usually suggested if there is:

  • Mastoid osteitis.

  • Intracranial extension.

  • Co-existing cholesteatoma.

  • Limited improvement after IV antibiotics.

• Mastoidectomy can be:¹⁷

  • Simple: infected mastoid air cells are removed.

  • Radical: the tympanic membrane and most middle ear structures are removed and the Eustachian tube is closed.

  • Modified: the ossicles and part of the tympanic membrane are preserved.

• Incision and drainage of a subperiosteal abscess is another procedure that may be required.

• Patients with intracranial spread may also need neurosurgical intervention.

• In cases with unusual infecting organisms, specialist infectious disease input may be helpful.

Complications of mastoiditis have been significantly reduced with the introduction of antibiotics. Many of the following complications are now very rare:

• Conductive and/or sensorineural hearing loss.

• Labirintite.

• Osteomielite or bone erosion.

• Extension to the zygoma (zygomatic mastoiditis).

• Subperiosteal abscess (abscess between the periosteum and mastoid bone; gives appearance of a protruding ear).

• Bezold's abscess.¹⁸This is a rare deep neck abscess where the infection erodes through the lateral mastoid cortex medial to the attachment of the sternocleidomastoid (SCM) muscle.

• Cranial nerve palsies (especially V, VI and VII).

• Intracranial spread leading to extradural abscess, cerebral abscess, subdural empyema and meningitis.

• Intracranial venous sinus thrombosis (e.g. lateral sinus thrombosis).

• Petrosite causing Gradenigo's syndrome (VIth cranial nerve palsy + deep trigeminal facial pain + suppurative otitis media).¹⁹

• Carotid artery spasm, arteritis, occlusion, rupture or metastatic septic emboli leading to intracerebral infection (all very rare and associated with the most severe cases).

• The prognosis for the vast majority of cases that are diagnosed early is excellent with a low chance of complications or severe hearing loss.

• Most cases who have had an episode of acute mastoiditis have no long-term otological sequelae.²⁰

• Complicated cases may, however, still lead to significant morbidity or even to death.