Cápsulas de orlistat
Alli, Orlos, Xenical
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 13 Oct 2023
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Take one capsule three times daily with your main meals.
If there is no fat in one of your meals, or if you miss a meal, there is no need for you to take a dose of orlistat.
Common side-effects include wind, loose stools and back passage (rectal) spotting, particularly at the beginning of treatment. These effects can be reduced by eating less fat in your meals.
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About orlistat
Tipo de medicamento | An anti-obesity medicine |
Usado para | The treatment of obesity alongside a reduced-calorie diet |
Também chamado de | Xenical®; Alli®; Orlos® |
Disponível como | Cápsulas |
Orlistat is a medicine that can help you to lose weight if you are obese or overweight. It works by interfering with the way fat is digested and absorbed by your body. It prevents the action of enzymes found in the digestive juices of your stomach and small intestine. These enzymes normally break down the fat which you consume in your diet, allowing it to be absorbed into your bloodstream. By blocking the enzymes' action, orlistat reduces the digestion of fat. This allows the fat you have eaten to be passed out of your body instead of being absorbed by your body, and this helps you to lose weight.
Orlistat only prevents about a third of the fat you eat from being absorbed so it is also important for you to eat a lower-fat weight-reducing diet, and to exercise regularly.
Orlistat is available on prescription, and lower-strength capsules (Alli® brand) can also be bought from pharmacies. It is not suitable for everyone and a number of guidelines apply as to who can be supplied with orlistat - more information about this can be found in the separate health information leaflet called Orlistat Weight Loss Medicine.
Before taking orlistat
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking orlistat it is important that your doctor or pharmacist knows:
Se você está grávida, tentando ter um bebê ou amamentando.
Se você tiver algum problema com o funcionamento dos seus rins.
If you have a condition called chronic malabsorption syndrome, where your food is not absorbed properly.
If you have a problem with the flow of bile to your liver, a condition called cholestasis.
Se você já teve uma reação alérgica a um medicamento.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
How to take orlistat
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about orlistat and will provide you with a full list of the side-effects which you may experience from taking it.
Take orlistat exactly as your doctor or pharmacist tells you to. There are two strengths of capsules - 60 mg and 120 mg. The lower-strength capsule is available from pharmacies whilst the higher-strength capsule is only available on a prescription from a doctor.
The usual dose of orlistat is one capsule (60 mg or 120 mg) taken with each of your three main meals of the day. Swallow the capsule with a drink of water as you are about to eat the meal or soon afterwards. It can be taken up to one hour after a meal. Do not take more than three doses a day.
Orlistat only works when there are fats in what you eat, so if you miss a meal or if you eat a meal which is fat-free then do not take a dose of orlistat.
If you forget to take a dose, do not worry; just take a capsule with your next meal as usual. Do not take two doses together to make up for a forgotten dose.
Obtendo o máximo do seu tratamento
Orlistat is only suitable if your body mass index (BMI) is 28 kg/m2 or greater. BMI is calculated by dividing your weight in kilograms by the square of your height in metres. So, for example, if you weigh 85 kg and are 1.7 metres tall, your BMI is 85/(1.7 x 1.7), which is 29. Alternatively, your practice nurse can measure and weigh you, and tell you your BMI.
To lose weight, the best chance of long-term success is to eat a well-balanced, calorie-controlled diet that is low in fat and rich in fruit and vegetables. If you are able, you should also exercise regularly. See the separate health information leaflet called Perda de Peso (Redução de Peso) for more details. Your practice nurse will be able to give you further help and advice about eating a healthy diet and taking suitable exercise.
If you have bought orlistat from a pharmacy, check your weight regularly and, if you have not lost weight after three months, see your doctor or pharmacist for further advice. You must lose at least 5% of your weight within three months from starting orlistat; if not, the treatment should be stopped. Do not continue taking orlistat for longer than six months without seeing a doctor.
If you have been prescribed orlistat, your doctor will want to review your weight and treatment regularly to decide if it is still appropriate for you to carry on taking orlistat. You must lose at least 5% of your weight within three months from starting orlistat; if not, the treatment is likely to be stopped. It may also be necessary for you to have some blood tests during treatment to check your blood lipids. If you continue to lose weight after six months, your doctor may advise that you continue to take orlistat for up to a year, or possibly longer.
The fat which remains undigested from your diet can cause changes in your bowel habit, resulting in wind, loose stools, and oily spotting from your back passage. Reducing the amount of fat you eat in your meals will reduce the likelihood of these harmless, but unpleasant, side-effects.
Orlistat can interfere with the absorption of various medicines, including possibly the contraceptive pill. If you take 'the pill' and you have severe diarrhoea as a side-effect of taking orlistat, it could reduce the effectiveness of the contraception. If you experience diarrhoea, use another method of contraception in addition to the pill - for example, a condom.
Orlistat can also interfere with the absorption of vitamins which are fat-soluble. These are vitamins A, D, E and K. If you decide to take a multivitamin supplement, take it at a time when you are not also taking orlistat. The best time to take the supplement would be at bedtime.
If you have diabetes, it is important that you speak with a doctor before you start taking orlistat, as it can affect the control of your diabetes. This may require extra monitoring.
After you stop taking orlistat, you may put some weight back on. Remembering to continue with your healthy eating and increased level of physical activity can help to prevent this.
Can orlistat cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with orlistat. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common orlistat side-effects (these affect more than 1 in 10 people) | O que posso fazer se passar por isso? |
Lower tummy (abdominal) discomfort, oily spotting from your back passage, wind, loose oily stools, an urgent need to open your bowels, pain around your back passage | These symptoms generally occur at the start of treatment as your body is adjusting. Reducing the fat content in your meals will help |
Dor de cabeça | Beba bastante água e peça a um farmacêutico que recomende um analgésico adequado. Se as dores de cabeça continuarem, informe seu médico |
Throat and chest infections, flu-like symptoms | If troublesome, speak with your doctor or pharmacist for advice |
Importante: if you experience any bleeding from your back passage, speak with your doctor for advice.
Se você sentir quaisquer outros sintomas que acha que podem ser devido às cápsulas, fale com seu médico ou farmacêutico para mais orientações.
How to store orlistat
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Se você comprar qualquer medicamento, verifique com um farmacêutico se é seguro tomá-lo com seus outros medicamentos.
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
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Perguntas frequentes
Can orlistat be used by anyone who wants to lose weight?
No, orlistat is not suitable for everyone. There are specific guidelines for its use, including a requirement for your body mass index (BMI) to be 28 kg/m2 or greater. If you are considering using orlistat, it's important to consult a doctor or pharmacist to determine if it is appropriate for you.
What is the difference between the prescription and pharmacy versions of orlistat?
Orlistat is available in two strengths: 60 mg and 120 mg capsules. The lower-strength 60 mg capsules (branded as Alli® or Orlos®) can be bought directly from pharmacies, while the higher-strength 120 mg capsules (branded as Xenical®) require a prescription from a doctor. Both strengths work the same way but differ in their availability and dosage.
How long can I continue to take orlistat?
If you bought orlistat from a pharmacy, you should not continue taking it for longer than six months without seeing a doctor. If you have been prescribed orlistat, your doctor will review your progress regularly. If you continue to lose weight after six months, your doctor may advise you to continue taking it for up to a year, or potentially longer, depending on your individual circumstances.
What should I do if I experience severe diarrhoea while taking orlistat and I am on the contraceptive pill?
If you are taking the contraceptive pill and experience severe diarrhoea as a side effect of orlistat, it could reduce the effectiveness of your contraception. In this situation, it is important to use an additional method of contraception, such as a condom, to ensure you remain protected.
Should I take a vitamin supplement while using orlistat?
Orlistat can interfere with the absorption of fat-soluble vitamins (A, D, E, and K). If you choose to take a multivitamin supplement, it's best to take it at a different time from your orlistat dose to ensure maximum absorption. The article suggests taking the supplement at bedtime.
Leitura adicional e referências
- Manufacturer's PIL, Xenical® 120 mg hard capsules; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated January 2022.
- Manufacturer's PIL, Alli® 60 mg hard capsules; Haleon UK Trading Limited, The electronic Medicines Compendium. Updated February 2023.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
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