Comprimidos de Modafinil
Provigil
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 14 Ago 2023
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Take modafinil at the same times each day to avoid missing any doses.
The most common side-effects include headache, feeling sick (nausea) and feeling dizzy.
You should not become pregnant whilst taking modafinil. Ask your doctor about which contraceptive methods are suitable for you while you are taking modafinil - hormonal contraceptives are not suitable.
Em resumo
Modafinil is a central nervous system stimulant used for daytime sleepiness from narcolepsy.
It helps control symptoms by increasing alertness and reducing daytime sleepiness.
Take your tablets exactly as prescribed by your doctor.
Women of childbearing potential must use effective contraception during and for two months after treatment.
Stop taking modafinil and contact your doctor immediately if you develop a rash or changes in mood or behaviour.
About modafinil
Tipo de medicamento | A central nervous system stimulant |
Usado para | Daytime sleepiness associated with narcolepsy in adults |
Também chamado de | Provigil® |
Disponível como | Comprimidos |
Narcolepsia is a long-term problem that affects your sleep. You feel excessively tired during the daytime but have disturbed night-time sleep. You can also have sleep attacks where you fall asleep at inappropriate times during the day without any warning.
Although there is no cure for narcolepsy, modafinil can help to control your symptoms. Modafinil works by stimulating the central nervous system to increase your alertness and reduce excessive sleepiness during the day.
Before taking modafinil
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking modafinil it is important that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
If you have any problems with the way your liver works or any problems with the way your kidneys work.
If you have a heart condition or high blood pressure (hypertension).
If you have ever had a mental health problem such as depression, psychosis or mania.
If you have ever had a problem with drug or alcohol misuse.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
Nota do autor clínico Michael Stewart 01/03/2020: Based on post-marketing reports from the USA, modafinil (Provigil®) may harm an unborn child. Modafinil should not be used during pregnancy. Women of childbearing potential must use effective contraception during treatment with modafinil and for two months after stopping. Discuss with your doctor which forms of contraception are suitable for you, as hormonal contraceptives are made less effective by modafinil. Alternative treatment options for narcolepsy should be used during pregnancy, such as behaviour modifications, good sleeping habits and scheduled daytime naps.
How to take modafinil
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about modafinil and will provide you with a full list of the side-effects which you may experience from taking it.
Take the tablets exactly as your doctor tells you to. There are two strengths of tablet available - 100 mg and 200 mg. When you first start modafinil it is usual to be prescribed a dose of 200 mg daily. You may be asked to take this as a single dose of 200 mg in the morning, or divided into 100 mg in the morning and 100 mg at midday. Your doctor or pharmacist will tell you which is right for you. Your dose may be increased after a little while, depending upon your symptoms.
Take your doses with a drink of water to help you swallow the tablet. Do not break or crush the tablet - it should be swallowed whole. You can take modafinil before or after food.
If you forget to take a dose, miss out the forgotten dose completely but make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Obtendo o máximo do seu tratamento
Keep your regular appointments with your doctor so that your progress can be monitored. You may need to have your blood pressure and heart rate checked regularly.
Modafinil can cause blurred vision or dizziness in some people and therefore it may affect your ability to use tools or machines, so take care when using them. Sleepiness associated with your condition can add to this.
Taking modafinil is not a replacement for a good sleep routine. It is still important that you aim to get around eight hours of sleep at night if possible. You should try to go to sleep and get up at about the same time each day.
In the UK, you are required by law to let the Driver and Vehicle Licensing Authority (DVLA) know if you are diagnosed with narcolepsy. You may be allowed to drive again when your symptoms are well controlled with medication, but you will need to have regular reviews. Your doctor will advise you about this.
Modafinil should not be used during pregnancy. Women of childbearing potential must use effective contraception during treatment with modafinil and for two months after stopping.
Hormonal contraceptives, including oral contraceptive pills, implants, intrauterine contraceptive devices (IUCDs) and contraceptive patches, are less effective when used with modafinil and are therefore not recommended. Speak to your doctor about which contraceptive methods are suitable for you while you are taking modafinil.
If you are planning to become pregnant you should stop taking modafinil and try alternative treatment options such as good sleep habits and scheduled daytime naps.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking modafinil.
Can modafinil cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with modafinil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Comum modafinil side-effects | O que posso fazer se passar por isso? |
Dor de cabeça | This usually passes within a day or so, but in the meantime, ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor |
Boca seca | Tente mascar chiclete sem açúcar ou chupar balas sem açúcar |
Feeling sick (nausea), indigestion, stomach ache | Mantenha-se em refeições simples - evite alimentos ricos ou picantes |
Diarreia | Beba bastante água para repor os líquidos perdidos |
Constipação | Tente manter uma dieta equilibrada e beba vários copos de água todos os dias |
Feeling dizzy or tired, blurred vision | Take special care when using tools or machines |
Flushing, loss of appetite, nervousness, difficulty sleeping, anxiety, depression, confusion or confused thinking, chest pain, fast heartbeat, numbness or tingling feelings | Speak with your doctor if any of these continue or become troublesome |
Importante: if you experience any of the following symptoms, stop taking modafinil and contact your doctor for advice imediatamente:
A rash or blisters on the skin.
Any changes to your mood, behaviour, or thinking.
Any suicidal thoughts, or thoughts about harming yourself.
Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, fale com seu médico ou farmacêutico para mais orientações.
How to store modafinil
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá imediatamente ao departamento de emergência do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você comprar qualquer medicamento, verifique com um farmacêutico se eles são adequados para tomar com seus outros medicamentos.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

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Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
Can I take modafinil for conditions other than narcolepsy?
Modafinil is specifically used for daytime sleepiness associated with narcolepsy in adults. The article does not mention its use for other conditions.
What should I do if I think I've taken too much modafinil?
If you suspect that you or someone else might have taken an overdose of modafinil, you should go to the accident and emergency department of your local hospital at once. Remember to take the medicine container with you, even if it is empty.
Are there any specific foods or drinks I should avoid while taking modafinil?
The article mentions that for side effects like feeling sick, indigestion, or stomach ache, you should stick to simple meals and avoid rich or spicy foods. It does not specify any other dietary restrictions.
Where can I find a complete list of modafinil's side effects?
A full list of all possible side-effects for modafinil can be found in the manufacturer's printed information leaflet that comes inside the medicine pack.
What is narcolepsy and how does modafinil help with it?
Narcolepsy is a long-term condition that impacts your sleep, causing excessive daytime tiredness, disturbed night-time sleep, and unexpected 'sleep attacks' during the day. Modafinil helps by stimulating your central nervous system to enhance alertness and reduce this excessive sleepiness.
Leitura adicional e referências
- Manufacturer's PIL, Modafinil (Provigil®) 100 mg and 200 mg tablets; Teva Pharma B.V., The electronic Medicines Compendium. Dated October 2021.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão prevista para: 13 Ago 2026
14 Ago 2023 | Última versão

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