Perampanel para epilepsia
Fycompa
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSLast updated 3 Oct 2022
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Perampanel is prescribed alongside other anti-epileptic medicines.
Take it once daily, at bedtime. Try not to miss any doses.
The most common side-effects are feeling dizzy and sleepy.
At a glance
Perampanel is an anti-epileptic medicine for adults and children aged 4 and older.
It is used alongside other medicines to treat seizures.
Take perampanel once daily at bedtime; do not chew, break or crush tablets.
Common side-effects include feeling dizzy, sleepy, or unsteady.
Tell your doctor if you experience mood changes, distressing thoughts, or feelings about suicide.
Do not stop taking perampanel suddenly without your doctor's advice.
Discuss suitable contraception if you are a woman and want to have a family.
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About perampanel for epilepsy
Tipo de medicamento | Um medicamento antiepiléptico |
Usado para | Epilepsy in adults and in children aged 4 years and older |
Também chamado de | Fycompa® |
Disponível como | Comprimidos e medicamentos líquidos orais |
Perampanel is used alongside other medicines in the treatment of seizures. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. Generalised seizures occur if you have a burst of abnormal electrical activity which spreads throughout the brain. Generalised seizures affect consciousness and may cause a convulsion. With a focal seizure, the burst of electrical activity stays in one part of the brain and therefore you tend to have localised or 'focal' symptoms. Because different parts of the brain control different functions, your symptoms will depend on which part of your brain is affected. Focal seizures can sometimes develop into seizures which affect all of your brain. These are called secondary generalised seizures.
Perampanel is prescribed alongside other anti-epileptic medicines. It works by stabilising the electrical activity in your brain.
Before taking perampanel
Voltar ao conteúdoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking perampanel it is important that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
Se você tiver algum problema com o funcionamento do seu fígado ou com o funcionamento dos seus rins.
Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
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How to take perampanel
Voltar ao conteúdoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about perampanel, and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take perampanel exactly as your doctor tells you to. You will be asked to take a low dose when you first start taking it, and then your dose will be increased as your body gets used to it. Your doctor or pharmacist will explain this to you, and directions will also be printed on the label of the pack to remind you about what the doctor said to you.
Perampanel is taken as a once-daily dose at bedtime. Try to avoid missing any doses. If you do forget, just take your next dose when it is due - do not take two doses together to make up for a forgotten dose.
Swallow the tablet whole with a drink of water. Do not chew, break or crush the tablet.
If you (or your child) have been prescribed the oral liquid medicine, follow the manufacturer's instructions for using the oral syringe.
Perampanel can be taken with or without food.
There are several strengths of perampanel tablets and each strength is a different colour. When you collect a new supply, check to make sure they are the colour you are expecting. If not, ask your pharmacist to check it out for you.
Obtendo o máximo do seu tratamento
Voltar ao conteúdoTente manter suas consultas regulares com seu médico. Isso é para que seu médico possa verificar seu progresso.
Quando você inicia um novo tratamento para epilepsia, pode haver uma mudança no número ou tipo de convulsões que você experimenta. Seu médico irá aconselhá-lo sobre isso.
Perampanel could make you feel sleepy, especially when you first start treatment.
Enquanto você está sendo tratado para epilepsia, há um pequeno risco de que você possa desenvolver mudanças de humor, pensamentos angustiantes e sentimentos sobre suicídio. Se isso acontecer, você deve informar seu médico imediatamente.
Pessoas com epilepsia devem parar de dirigir inicialmente. Seu médico irá aconselhá-lo sobre se e quando será possível retomar a direção.
Drinking alcohol while you are on perampanel can increase the risk of side-effects and may not be recommended for you. Ask for your doctor's advice.
Many anti-epileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist antes you become pregnant.
You need to take perampanel regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.
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Can perampanel cause problems?
Voltar ao conteúdoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with perampanel. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common perampanel side-effects | O que posso fazer se passar por isso? |
Sentindo-se tonto, sonolento, cansado ou instável; visão dupla | Tome cuidado para não cair ou tropeçar ao se movimentar. Não dirija e não use ferramentas ou máquinas |
Sentindo-se enjoado (náusea) | Mantenha-se em alimentos simples - evite refeições gordurosas ou picantes |
Changes in appetite or weight, changes in mood (such as feeling aggressive, confused or anxious), back pain | Se algum desses se tornar problemático, discuta com seu médico |
Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, fale com seu médico ou farmacêutico para mais orientações.
How to store perampanel
Voltar ao conteúdoMantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
The oral liquid medicine lasts for 90 days after first opening. It's a good idea to write the date you opened the bottle on to the label.
Informações importantes sobre todos os medicamentos
Voltar ao conteúdoInformações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá imediatamente ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio, para que o médico saiba o que foi tomado.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você estiver prestes a fazer uma operação ou qualquer tratamento dentário, por favor, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Se você comprar qualquer medicamento, verifique com um farmacêutico se é seguro tomá-lo com os medicamentos prescritos.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is the main purpose of perampanel and how does it help with epilepsy?
Perampanel is an anti-epileptic medicine used to treat seizures. It works by stabilising the electrical activity in your brain to help control the abnormal bursts of activity that cause seizures. It is always used alongside other anti-epileptic medicines.
Can I take perampanel if I am pregnant or breastfeeding?
If you are pregnant, trying for a baby, or breastfeeding, it is important to inform your doctor before starting perampanel. Many anti-epileptic medicines can harm an unborn child, so your doctor will need to discuss suitable contraception or specialist advice if you plan to have a family.
What should I do if I forget to take a dose of perampanel?
If you forget to take a dose, just take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Are there different formulations of perampanel, and how should they be stored?
Perampanel is available as tablets and an oral liquid medicine. Tablets should be swallowed whole with water and not chewed, broken, or crushed. If you have the oral liquid medicine, you should follow the manufacturer's instructions for using the oral syringe. All medicines should be kept out of reach and sight of children, in a cool, dry place away from direct heat and light. The oral liquid medicine lasts for 90 days after first opening, so it's a good idea to write the opening date on the label.
Can perampanel affect my mood or mental health?
While being treated for epilepsy, there is a small risk that you may develop mood changes, distressing thoughts, and feelings about suicide. If you experience these, you must tell your doctor straightaway.
What should I do if I experience side-effects like dizziness or sleepiness while taking perampanel?
If you feel dizzy, sleepy, tired, unsteady, or experience double vision, you should take care not to fall or trip and avoid driving or using tools or machines. If these or any other side-effects become troublesome, or if you experience any other symptoms you think might be due to the medicine, you should speak with your doctor or pharmacist for further advice.
Is it safe to drink alcohol while taking perampanel?
Drinking alcohol while you are on perampanel can increase the risk of side-effects. It may not be recommended for you, so you should ask your doctor for advice on this.
Leitura adicional e referências
- Manufacturer's PIL, Fycompa® 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg film-coated tablets; Eisai Ltd, The electronic Medicines Compendium. Dated July 2021.
- Manufacturer's PIL, Fycompa® 0.5 mg/1 ml oral suspension; Eisai Ltd, The electronic Medicines Compendium. Dated July 2021.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
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About the authorView full bio

Helen Allen, MPharm
Pharmacist, Medical Author
MPharm
Helen Allen qualified as a Pharmacist in 1979 and spent 3 years as the drug information leaflets' author for EMIS.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão agendada: 1 de abr de 2027
3 Oct 2022 | Última versão
10 May 2013 | Publicado originalmente
Escrito por:
Helen Allen, MPharm

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