Acetato de ciproterona - um antiandrogênico para homens
Cyprostat, Androcur
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSLast updated 10 Jun 2024
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Take cyproterone tablets with a drink of water and something to eat.
Cyproterone may make you feel tired or weak. If this happens, do not drive and do not use tools or machines.
Cyproterone can affect the way your liver works and the way your adrenal glands work. Your doctor will discuss the risk of these with you before you start the treatment.
At a glance
Cyproterone is a medicine that blocks the action of male sex hormones.
It is used to treat prostate cancer and to control hypersexuality in men.
Take cyproterone with food and follow your doctor's dosing instructions carefully.
Cyproterone can cause tiredness, so do not drive or use machines if affected.
Your doctor will arrange blood tests to monitor your liver and adrenal gland function.
Seek medical advice if you experience yellow skin, stomach pain, or severe tiredness.
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About cyproterone
Tipo de medicamento | Anti-androgen |
Usado para | To treat prostate cancer in men; to control hypersexuality in men |
Também chamado de | Cyprostat® (used for prostate cancer); Androcur® (used for hypersexuality) |
Disponível como | Comprimidos |
Cyproterone belongs to a group of medicines known as anti-androgens. This means that it blocks the actions of male sex hormones called androgens, and it also reduces the amount of male hormones your body produces. This anti-androgen action can be helpful in the treatment of two different conditions - in the treatment of câncer de próstata, and to control the sex drive in men with hypersexuality.
In prostate cancer, the cancer cells need the male hormone testosterone to grow and multiply well. Hormone treatments like cyproterone block the effect of testosterone on prostate cancer cells. This slows down the growth of the cancer. Cyproterone also helps to reduce symptom 'flares' and side-effects from other treatments which may be used for the cancer, or following surgery.
In men who have hypersexuality, cyproterone is used to control sexual desire or deviation. If you are prescribed cyproterone for this reason, your doctor will ask you to sign an agreement before you start the treatment.
Cyproterone is also found in very low doses in a contraceptive tablet called co-cyprindiol. It is useful for managing cicatrizes de acne or excess hair growth (hirsutism) whilst also providing contraception.
Before taking cyproterone
Voltar ao conteúdoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking cyproterone it is important that your doctor knows:
If you are under 18 years old. Cyproterone is not recommended for this age group.
If you are depressed.
If you have any problems with the way your liver works, or if you drink a lot of alcohol.
Se você tem diabetes.
If you have blood vessel problems, such as if you have ever had a blood clot in a leg or lung.
If you have a type of anaemia known as sickle cell anaemia.
If you have ever had a type of brain tumour called meningioma, or if you have been diagnosed with another type of cancer (other than prostate cancer if that is what you are being treated for).
Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
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How to take cyproterone
Voltar ao conteúdoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cyproterone and will provide you with a full list of the side-effects which you may experience from taking it.
Take cyproterone exactly as your doctor tells you to. How you should take the tablets will depend on what condition you are being treated for, so your doctor will give you full directions. Your dose will also be printed on the label of the pack to remind you about what the doctor said to you.
Take your doses with a snack, or just after eating a meal. Swallow the tablets with a drink of water.
Try to take cyproterone at the same times of day each day. This will help you to remember to take your doses regularly.
If you forget to take a dose, take it as soon as you remember unless your next dose is due. If it is nearly time for your next dose then take the next dose when it is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
Obtendo o máximo do seu tratamento
Voltar ao conteúdoPlease keep your regular appointments with your doctor. Your doctor will want you to have some blood tests both before and during your treatment. The tests will check the levels of your blood cells, and that your liver stays healthy. Your doctor will also want to check that your adrenal glands are not being affected by the treatment.
Cyproterone can make you feel tired or weak. If this happens to you, do not drive and do not use tools or machines, as these symptoms may put others as well as yourself at risk.
Your doctor may recommend you do not drink alcohol while you are on cyproterone. This is because regularly drinking alcohol can stop cyproterone from working as well as it should.
When you have been taking cyproterone for some weeks, your sperm count will reduce and you are likely to become unable to father a child. You must not, however, rely on cyproterone as a contraceptive. Although this infertility is likely to reverse when you stop taking cyproterone, you should speak with your doctor if you are thinking of having children in the future.
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Can cyproterone cause problems?
Voltar ao conteúdoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cyproterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common cyproterone side-effects | O que posso fazer se passar por isso? |
Reduced sperm count | Your doctor will discuss this with you before your treatment starts |
Feeling tired or weary | Se isso acontecer, não dirija e não use ferramentas ou máquinas |
Hot flushes and sweating | Try to keep yourself cool by wearing light and airy clothes |
Changes in your weight, feeling depressed or restless, breast tenderness, feeling short of breath | Se algum desses se tornar problemático, fale com seu médico |
Importante: cyproterone can affect the way your liver works and the way your adrenal glands work. Your doctor will discuss this with your before you start the treatment, but it is important you tell your doctor if you develop any of the following:
Any yellowing of your skin or of the whites of your eyes, or if you develop any stomach discomfort or pain that does not go away quickly. These can be signs that your liver is being affected.
If you feel very tired, start losing your appetite or weight, develop diarrhoea or sickness (vomiting), or feel particularly irritable or depressed. These can be signs that your adrenal glands are being affected.
Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, por favor, fale com seu médico ou farmacêutico para mais orientações.
How to store cyproterone
Voltar ao conteúdoMantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Voltar ao conteúdoInformações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Não o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você estiver prestes a fazer uma operação ou tratamento dentário, por favor, informe à pessoa que realizará o tratamento quais medicamentos você está tomando.
Se você comprar qualquer medicamento, verifique com um farmacêutico se eles são adequados para tomar com seus outros medicamentos.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

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Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is cyproterone and how does it work to treat prostate cancer?
Cyproterone is a type of anti-androgen medicine. It works by blocking the effects of male sex hormones, called androgens, and also by reducing how much of these hormones your body makes. In prostate cancer, the cancer cells rely on the male hormone testosterone to grow. Cyproterone stops testosterone from affecting these cancer cells, which helps to slow down the cancer's growth. It can also help to ease symptom 'flares' and side-effects that might occur with other cancer treatments or after surgery.
Why would a doctor ask me to sign an agreement before starting cyproterone for hypersexuality?
If you are prescribed cyproterone to help control sexual desire or deviation due to hypersexuality, your doctor will ask you to sign an agreement before you begin treatment. This is part of the process for using the medication for this specific condition.
Can cyproterone affect my ability to have children?
Yes, cyproterone can affect your fertility. After taking it for several weeks, your sperm count is likely to decrease, and you may become unable to father a child. While this infertility is expected to reverse once you stop taking cyproterone, you should discuss your plans for having children with your doctor if this is a concern for you in the future.
What are the common side-effects of cyproterone and what should I do about them?
Common side-effects include reduced sperm count, feeling tired or weary, hot flushes, sweating, changes in weight, feeling depressed or restless, breast tenderness, and feeling short of breath. If you experience tiredness, you should avoid driving or using tools/machines. For hot flushes and sweating, try to stay cool with light clothing. If any side-effects, especially changes in weight, depression, restlessness, breast tenderness, or shortness of breath, become troublesome, you should speak with your doctor.
Why do I need blood tests before and during my treatment with cyproterone?
Your doctor will ask you to have regular blood tests both before and throughout your treatment with cyproterone. These tests are important to check the levels of your blood cells, ensure your liver remains healthy, and monitor that your adrenal glands are not being affected by the medication. Cyproterone can impact both liver and adrenal gland function, so these tests help your doctor keep track of your health while you're on the treatment.
Can cyproterone be used by women, for example, for acne or excess hair?
Yes, cyproterone is also available in very low doses within a contraceptive pill called co-cyprindiol. This specific formulation is used to help manage acne or excess hair growth (hirsutism) in women, while also providing contraception.
What should I do if I forget to take a dose of cyproterone?
If you forget a dose, take it as soon as you remember, unless it's nearly time for your next scheduled dose. If it's almost time for the next dose, simply skip the forgotten one and take the next dose as usual. Do not take two doses at once to make up for a missed dose.
Leitura adicional e referências
- Manufacturer's PIL, Cyprostat® 50 mg tablets; Bayer plc, The electronic Medicines Compendium. Dated June 2022.
- Manufacturer's PIL, Androcur® 50 mg tablets; Bayer plc, The electronic Medicines Compendium. Dated June 2022.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão prevista para: 13 Jun 2027
10 Jun 2024 | Última versão

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