Comprimidos de Co-ciprinidol
Clairette, Dianette
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 4 Dez 2024
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Co-cyprindiol tablets are prescribed for women with certain skin conditions when contraception is also required.
Carefully read and follow the printed information leaflet from inside the pack.
Em resumo
Co-cyprindiol is a hormone treatment used for severe acne or hirsutism in women.
It contains two ingredients, ethinylestradiol and cyproterone.
Co-cyprindiol also acts as an oral contraceptive pill.
Take one tablet daily for 21 days, then have seven tablet-free days.
It often takes 3-4 months for skin conditions to improve.
Stop taking it and contact a doctor immediately if you experience severe chest pain, breathlessness, leg swelling, or yellow skin/eyes.
About co-cyprindiol
Tipo de medicamento | A hormone treatment |
Usado para | Severe acne or hirsutism in women |
Também chamado de | Clairette®; Dianette® |
Disponível como | Comprimidos |
Co-cyprindiol is prescribed for two different skin conditions in women - cicatrizes de acne e hirsutismo.
Acne is a common skin condition which is often treated by skin creams or antibiotic tablets. You will have been prescribed co-cyprindiol for acne if other treatments have not been sufficiently effective for you.
Hirsutism is a condition where dark, thick hair grows in places where it doesn't usually grow in women, such as on the face or chest.
Co-cyprindiol contains two ingredients, ethinylestradiol and cyproterone. Ethinylestradiol is an oestrogen, which is a female sex hormone. Cyproterone is an anti-androgen. Androgens are responsible for stimulating the glands on your skin which produce an oil (sebum) and they also encourage hair growth. Co-cyprindiol works by reducing the amount of androgen you produce, which helps to clear acne and reduces excess hair growth.
Co-cyprindiol is also an oral contraceptive pill. Although it is not prescribed solely for this purpose, it can be helpful if you have one of the skin conditions mentioned above and also wish to take oral contraception.
Before taking co-cyprindiol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking co-cyprindiol it is important that your doctor knows:
If you are breastfeeding, or if you think you could be pregnant.
If you have ever had an unwanted blood clot, or blood vessel problems.
If you have a breast lump, or if you have had breast cancer.
If you have any problems with the way your liver works, or if you have gallstones.
Se você tiver qualquer sangramento vaginal além do seu período menstrual normal.
If you have high blood levels of fats (lipids), or if you have been told you have high blood levels of prolactin.
If you have any of the following conditions: heart disease, migraine, systemic lupus erythematosus (SLE), porphyria, sickle cell disease, or an inflammatory bowel condition.
If you have ever been diagnosed with depression, or if you have had a transient ischaemic attack (called a 'TIA' or 'mini stroke'), or if you have had haemolytic uraemic syndrome.
If during a pregnancy you have had problems such as severe itching and blistering of your skin, jaundice, or any involuntary jerky movements.
Se você já teve uma reação alérgica a um medicamento.
If you are taking any other medicines, including those available to buy without a prescription and herbal or complementary medicines. This is important because some medicines may stop combined hormonal contraceptives from working properly.
How to take co-cyprindiol
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about co-cyprindiol, and it will also provide you with a full list of side-effects which you could experience from taking it.
Starting on the first day of your next period, take one tablet daily for 21 days and then have seven days without taking a tablet. Continue to take one tablet daily for 21 days and then have seven pill-free days until your doctor tells you otherwise.
You should take your tablets at the same time of day each day. This is particularly important if you are taking them to prevent pregnancy. If you forget to take a tablet on time, take it as soon as you remember, and then take the next dose at your usual time (even if this means taking two tablets on the same day). If you are more than 12 hours late taking a tablet, your protection against pregnancy could be reduced. In this case, for the following seven days you must either use a barrier method of contraception such as a condom, or avoid sex. If these seven days run beyond the end of your packet of pills, start the next packet straightaway without any tablet-free days. This means you may not have a period until the end of the two packets.
Obtendo o máximo do seu tratamento
Try to keep your regular appointments with your doctor or clinic. This is so your doctor can check on your progress. You will need to have your blood pressure checked from time to time.
If you suspect at any time that you may be pregnant, stop taking co-cyprindiol and see your doctor or pharmacist for a pregnancy test straightaway.
Importante: if you have a bout of being sick (vomiting) or diarrhoea, it can reduce the effectiveness of the contraception. If this happens, use a condom if you have sex during the illness and for seven days after you recover. If the illness occurs during the last week of your tablets, miss out the seven pill-free days and start a new pack of tablets straightaway. This means you may not have a period until the end of the two packets.
Please note: co-cyprindiol taken as a contraceptive will not protect you from sexually transmitted infections or HIV infection. If you are concerned about either of these, please ask your pharmacist or doctor for advice on safe sex.
There is a slightly increased risk of a clot in a blood vessel (thromboembolism) with hormonal contraceptives like co-cyprindiol, particularly during the first year of use. Travelling that involves long periods of sitting still (for example, flying for more than three hours) can add to the risk of a blood clot. It's always a good idea to exercise your feet and ankles regularly while travelling, and you may wish to consider wearing flight socks during long flights.
Taking hormonal contraception can increase the risk of some types of cancer. Research suggests a small increased risk of breast and cervical cancer in women taking co-cyprindiol. Your doctor will be able to discuss the risks of this with you.
Treatment with hormones can affect your mood and may impact on your mental health. Speak to your doctor if you are worried about any mood changes after starting treatment with co-cyprindiol.
Before having any kind of surgery, you must tell your doctor or surgeon that you are taking these tablets. This is because your doctor may decide that you need to stop the treatment for a period of time to reduce your risk of unwanted blood clots.
It is likely to take at least 3-4 months for your skin condition to clear up. Your doctor will regularly review your progress during this time. If you still need contraception once the course of treatment with co-cyprindiol has stopped, an alternative contraceptive pill will be prescribed for you.
Can co-cyprindiol cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the common ones associated with co-cyprindiol. You will find a full list in the manufacturer's information leaflet supplied with the tablets. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common co-cyprindiol side-effects (these affect fewer than 1 in 10 women) | O que posso fazer se passar por isso? |
Sentindo-se mal (náusea), dor de barriga (dor abdominal) | Eat simple meals - avoid rich and spicy food (see also the information above on bouts of sickness) |
Dor de cabeça | Ask your pharmacist to recommend a suitable painkiller. If the headache continues or is sudden and severe, contact your doctor for advice |
Breast tenderness, increased weight, mood changes | Se houver problemas, fale com seu médico |
Importante: co-cyprindiol can have some serious side-effects, but these are very uncommon. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:
Any sudden or severe chest pain.
Any sudden breathlessness or if you cough up any blood.
Any swelling or pain in a leg.
Severe stomach pain.
An unusually painful or severe headache, or any loss of your sight or hearing, or any difficulty swallowing.
A bad fainting attack, a fit, or any numbness on one side of your body,
Any yellowing of your skin or of the whites of your eyes (jaundice).
Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, por favor, fale com seu médico ou farmacêutico para mais orientações.
How to store co-cyprindiol
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Never take more than the prescribed dose. If you suspect that you or someone else might have an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você comprar qualquer medicamento, sempre verifique com um farmacêutico se é seguro tomá-lo com seus outros medicamentos.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
If you have any questions about this medicine, please ask your pharmacist for advice.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
How long will it take for co-cyprindiol to improve my skin condition?
It is likely to take at least 3-4 months for your acne or hirsutism to show significant improvement. Your doctor will regularly review your progress during this period.
Does co-cyprindiol protect me from sexually transmitted infections?
No, co-cyprindiol, even when taken as a contraceptive, does not offer protection against sexually transmitted infections (STIs) or HIV. If you are concerned about STIs, you should ask your pharmacist or doctor for advice on safe sex practices.
Can I continue to take co-cyprindiol indefinitely if it helps my condition?
It is not typically prescribed for indefinite use. If you still require contraception after your course of co-cyprindiol treatment has ended, your doctor will prescribe an alternative contraceptive pill for you.
What should I do if I travel for a long period of time while taking co-cyprindiol?
Long periods of sitting still, such as during flights lasting over three hours, can increase the risk of blood clots. It's advisable to regularly exercise your feet and ankles during travel, and you might consider wearing flight socks for long journeys to help reduce this risk.
Will co-cyprindiol affect my mood?
Treatment with hormones like co-cyprindiol can affect your mood and may have an impact on your mental health. If you are concerned about any changes in your mood after starting this treatment, you should speak to your doctor.
Is it safe to continue co-cyprindiol before surgery?
Before you have any type of surgery, you must inform your doctor or surgeon that you are taking co-cyprindiol. Your doctor may decide that you need to stop the treatment for a period to reduce your risk of unwanted blood clots during the surgical period.
Leitura adicional e referências
- Manufacturer's PIL, Dianette®; Bayer plc, The electronic Medicines Compendium. Dated February 2023.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão prevista: 4 de Dez 2027
4 Dez 2024 | Última versão

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