RB transcriptional corepressor 1
Última atualização 8 de maio de 2023
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A RB1 gene provides instructions for making a protein called pRB. This protein acts as a tumour suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or in an uncontrolled way. Under certain conditions, pRB stops other proteins from triggering DNA replication, the process by which DNA makes a copy of itself. Because DNA replication must occur before a cell can divide, tight regulation of this process controls cell division and helps prevent the growth of tumours. Additionally, pRB interacts with other proteins to influence cell survival, the self-destruction of cells (apoptosis), and the process by which cells mature to carry out special functions (differentiation).
Normal function
A RB1 gene provides instructions for making a protein called pRB. This protein acts as a tumour suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or in an uncontrolled way. Under certain conditions, pRB stops other proteins from triggering DNA replication, the process by which DNA makes a copy of itself. Because DNA replication must occur before a cell can divide, tight regulation of this process controls cell division and helps prevent the growth of tumours. Additionally, pRB interacts with other proteins to influence cell survival, the self-destruction of cells (apoptosis), and the process by which cells mature to carry out special functions (differentiation).
Conditions referring to this gene or chromosome
Other names
p105-Rb
PP110
PPP1R130
RB
RB1 gene
RB_HUMAN
retinoblastoma 1
Retinoblastoma 1 (including osteosarcoma)
Retinoblastoma-1
Retinoblastoma-associated protein
Related patient information and medicines
Patient information leaflet
Biópsia renal
A biópsia renal involves taking a small sample de tissue from the kidney. Cells from the kidney can then be looked at in detail. It is used to diagnose and monitor certain conditions. Note : the information below is a general guide only. The arrangements, and the way tests are performed, may vary between different hospitals. Always follow the.
Patient information leaflet
Tratamento para diabetes tipo 2
Although diabetes cannot be cured, it can be treated successfully. If a high blood sugar level is brought down to a normal level, your symptoms will ease and your risk of long-term complications will be much lower. Managing type 2 diabetes Keeping your blood sugar (glucose) well controlled is key to reducing your risk of long-term complications.
Patient information leaflet
Viajando para locais remotos
In the event of serious illness or injury it could be hours or days before you can be evacuated. Before travelling, consult the Foreign and Commonwealth Office (FCO) website (see under 'Further Reading and References' below) for advice on travelling to your destination. There could be local unrest or terrorist activity that does not make daily.
Patient information leaflet
Fibrilação atrial e prevenção de AVC
A para resfriado used to prevenir a atrial fibrillation-related stroke are called anticoagulants. These help to stop blood clots forming in your blood vessels. Why does atrial fibrillation increase your risk of having a stroke. The main complication of atrial fibrillation (AF) is an increased risk of having a stroke. AF can interfere with the blood.
Patient information leaflet
Posso tomar Atorvastatina e suplementos de fibra juntos?
...re supplements at the same time as atorvastatin pode lower the amount of medicineOur Verificador de Interações de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Aviso Legal Este information é for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
Hemofilia
Hemofilia is a condition where there is a deficiency of clotting factors, so people with this condition usually have prolonged bleeding. There is no cure but with available treatments most people with haemophilia are able to live normal lives. What is haemophilia. Haemophilia is a rare bleeding disorder caused by deficiency of clotting factors..
Leitura adicional e referências
- RB transcriptional corepressor 1; MedlinePlus, National Library of Medicine.
- Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer. 2002 Dec;2(12):910-7. doi: 10.1038/nrc950.
- de Andrade AF, da Hora Barbosa R, Vargas FR, Ferman S, Eisenberg AL, Fernandes L, Bonvicino CR. A molecular study of first and second RB1 mutational hits in retinoblastoma patients. Cancer Genet Cytogenet. 2006 May;167(1):43-6. doi: 10.1016/j.cancergencyto.2005.08.017.
- Du W, Pogoriler J. Retinoblastoma family genes. Oncogene. 2006 Aug 28;25(38):5190-200. doi: 10.1038/sj.onc.1209651.
- Goodrich DW. The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene. 2006 Aug 28;25(38):5233-43. doi: 10.1038/sj.onc.1209616.
- Herwig S, Strauss M. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem. 1997 Jun 15;246(3):581-601. doi: 10.1111/j.1432-1033.1997.t01-2-00581.x.
- Knudsen ES, Knudsen KE. Retinoblastoma tumor suppressor: where cancer meets the cell cycle. Exp Biol Med (Maywood). 2006 Jul;231(7):1271-81. doi: 10.1177/153537020623100713.
- Korabiowska M, Ruschenburg I, Betke H, Stachura J, Schlott T, Cardo CC, Brinck U. Downregulation of the retinoblastoma gene expression in the progression of malignant melanoma. Pathobiology. 2001;69(5):274-80. doi: 10.1159/000064338.
- Leiderman YI, Kiss S, Mukai S. Molecular genetics of RB1--the retinoblastoma gene. Semin Ophthalmol. 2007 Oct-Dec;22(4):247-54. doi: 10.1080/08820530701745165.
- Liu H, Dibling B, Spike B, Dirlam A, Macleod K. New roles for the RB tumor suppressor protein. Curr Opin Genet Dev. 2004 Feb;14(1):55-64. doi: 10.1016/j.gde.2003.11.005.
- Lohmann DR, Gallie BL. Retinoblastoma: revisiting the model prototype of inherited cancer. Am J Med Genet C Semin Med Genet. 2004 Aug 15;129C(1):23-8. doi: 10.1002/ajmg.c.30024.
- Richter S, Vandezande K, Chen N, Zhang K, Sutherland J, Anderson J, Han L, Panton R, Branco P, Gallie B. Sensitive and efficient detection of RB1 gene mutations enhances care for families with retinoblastoma. Am J Hum Genet. 2003 Feb;72(2):253-69. doi: 10.1086/345651. Epub 2002 Dec 18.
- Sampieri K, Hadjistilianou T, Mari F, Speciale C, Mencarelli MA, Cetta F, Manoukian S, Peissel B, Giachino D, Pasini B, Acquaviva A, Caporossi A, Frezzotti R, Renieri A, Bruttini M. Mutational screening of the RB1 gene in Italian patients with retinoblastoma reveals 11 novel mutations. J Hum Genet. 2006;51(3):209-216. doi: 10.1007/s10038-005-0348-3. Epub 2006 Feb 4.
- Wolff EM, Liang G, Jones PA. Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. Nat Clin Pract Urol. 2005 Oct;2(10):502-10. doi: 10.1038/ncpuro0318.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.