H19 imprinted maternally expressed transcript
Última atualização 4 Mar 2025
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The H19 gene provides instructions for making a molecule of RNA, a chemical cousin of DNA. This RNA molecule is noncoding, which means that it does not contain instructions for making a protein. Researchers believe that this noncoding RNA acts as a tumour suppressor, keeping cells from growing and dividing too fast or in an uncontrolled way. The H19 gene is highly active in various tissues before birth and appears to play an important role in early development.
Normal function
The H19 gene provides instructions for making a molecule of RNA, a chemical cousin of DNA. This RNA molecule is noncoding, which means that it does not contain instructions for making a protein. Researchers believe that this noncoding RNA acts as a tumour suppressor, keeping cells from growing and dividing too fast or in an uncontrolled way. The H19 gene is highly active in various tissues before birth and appears to play an important role in early development.
In most cases, people receive one copy of each gene from the egg cell and one copy from the sperm cell. Both copies are typically active, or "turned on," in cells. However, the activity of the H19 gene depends on whether the gene comes from the egg cell or the sperm cell. Typically, only the H19 gene inherited from the egg cell is active. This parent-specific difference in gene activation is called genomic imprinting.
A nearby region of DNA regulates the genomic imprinting of the H19 gene and another gene, called IGF2, that is important for growth and development. This region is known as an imprinting center or imprinting control region. In a process known as methylation, small molecules called methyl groups are added to the imprinting center to regulate the activity of the H19 and IGF2 genes. Typically, only the H19 imprinting center that is derived from the sperm cell is methylated.
Conditions referring to this gene or chromosome
Other names
ASM
D11S813E
H19, imprinted maternally expressed transcript (non-protein coding)
LINC00008
MIR675HG
NCRNA00008
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Leitura adicional e referências
- H19 imprinted maternally expressed transcript; MedlinePlus, National Library of Medicine.
- Abu-Amero S, Monk D, Frost J, Preece M, Stanier P, Moore GE. The genetic aetiology of Silver-Russell syndrome. J Med Genet. 2008 Apr;45(4):193-9. doi: 10.1136/jmg.2007.053017. Epub 2007 Dec 21.
- Cai X, Cullen BR. The imprinted H19 noncoding RNA is a primary microRNA precursor. RNA. 2007 Mar;13(3):313-6. doi: 10.1261/rna.351707. Epub 2007 Jan 19.
- Eggermann T, Eggermann K, Schonherr N. Growth retardation versus overgrowth: Silver-Russell syndrome is genetically opposite to Beckwith-Wiedemann syndrome. Trends Genet. 2008 Apr;24(4):195-204. doi: 10.1016/j.tig.2008.01.003. Epub 2008 Mar 7.
- Gabory A, Jammes H, Dandolo L. The H19 locus: role of an imprinted non-coding RNA in growth and development. Bioessays. 2010 Jun;32(6):473-80. doi: 10.1002/bies.200900170.
- MacFarland SP, Duffy KA, Bhatti TR, Bagatell R, Balamuth NJ, Brodeur GM, Ganguly A, Mattei PA, Surrey LF, Balis FM, Kalish JM. Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. Pediatr Blood Cancer. 2018 Oct;65(10):e27296. doi: 10.1002/pbc.27296. Epub 2018 Jun 22.
- Nativio R, Sparago A, Ito Y, Weksberg R, Riccio A, Murrell A. Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet. 2011 Apr 1;20(7):1363-74. doi: 10.1093/hmg/ddr018. Epub 2011 Jan 31.
- Sparago A, Cerrato F, Vernucci M, Ferrero GB, Silengo MC, Riccio A. Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet. 2004 Sep;36(9):958-60. doi: 10.1038/ng1410. Epub 2004 Aug 15.
- Tian F, Yourek G, Shi X, Yang Y. The development of Wilms tumor: from WT1 and microRNA to animal models. Biochim Biophys Acta. 2014 Aug;1846(1):180-7. doi: 10.1016/j.bbcan.2014.07.003. Epub 2014 Jul 11.
- Turner JT, Brzezinski J, Dome JS. Wilms Tumor Predisposition. 2003 Dec 19 [updated 2022 Mar 24]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1294/
- Wakeling EL, Brioude F, Lokulo-Sodipe O, O'Connell SM, Salem J, Bliek J, Canton AP, Chrzanowska KH, Davies JH, Dias RP, Dubern B, Elbracht M, Giabicani E, Grimberg A, Gronskov K, Hokken-Koelega AC, Jorge AA, Kagami M, Linglart A, Maghnie M, Mohnike K, Monk D, Moore GE, Murray PG, Ogata T, Petit IO, Russo S, Said E, Toumba M, Tumer Z, Binder G, Eggermann T, Harbison MD, Temple IK, Mackay DJ, Netchine I. Diagnosis and management of Silver-Russell syndrome: first international consensus statement. Nat Rev Endocrinol. 2017 Feb;13(2):105-124. doi: 10.1038/nrendo.2016.138. Epub 2016 Sep 2.
- Wang KH, Kupa J, Duffy KA, Kalish JM. Diagnosis and Management of Beckwith-Wiedemann Syndrome. Front Pediatr. 2020 Jan 21;7:562. doi: 10.3389/fped.2019.00562. eCollection 2019.
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