Câncer de mama
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Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumour. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.
Descrição
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumour. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.
In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. As the cancer progresses, signs and symptoms can include a lump or thickening in or near the breast; a change in the size or shape of the breast; nipple discharge, tenderness, or retraction (turning inward); and skin irritation, dimpling, redness, or scaliness. However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a person definitely has breast cancer.
In some cases, cancerous cells can invade surrounding breast tissue. In these cases, the condition is known as invasive breast cancer. Sometimes, tumours spread to other parts of the body. If breast cancer spreads, cancerous cells most often appear in the bones, liver, lungs, or brain. Tumours that begin at one site and then spread to other areas of the body are called metastatic cancers.
A small percentage of all breast cancers cluster in families. These cancers are described as hereditary and are associated with inherited gene mutations. Hereditary breast cancers tend to develop earlier in life than noninherited (sporadic) cases, and new (primary) tumours are more likely to develop in both breasts.
Padrões de herança
The source lists the following possible inheritance patterns: Not inherited; Autosomal dominant; Pattern unknown. More than one pattern can apply in different cases.
Related genes
Other names
Breast cancer, familial
Breast carcinoma
Cancer of breast
Malignant neoplasm of breast
Malignant tumour of breast
Mammary cancer
Related patient information and medicines
Patient information leaflet
Câncer de mama
Breast cancer is the most common cancer in women. Most cases occur in women over the age of 50 but breast cancer can occur in younger women. If breast cancer is diagnosed at an early stage, less treatment may be needed and it is more likely to be effective. In general, the... Over 3 out of 4 women diagnosed with breast cancer are still alive 10.
Patient information leaflet
Câncer de mama em homens
We think of câncer de mama as a disease of women because it is usually women who are affected. However, breast cancer can develop occasionally in men too. Men who are not ... Whatever your gender, it is very important to see a doctor as soon as possible if you develop a lump in your breast. What is breast cancer. Cancer is a condition where cells.
Patient information leaflet
Fatos e fatores de risco do câncer de mama
Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families porque of their genetic makeup. If ... Some facts about breast cancer Breast cancer is one of the most common cancers in the world. In the UK about 1 in 8 women develop breast cancer at some stage of their lives. Para detalhes of.
Medicine leaflet
Letrozol para câncer de mama
These can occur in more than 1 in 10 women who take letrozole. About letrozole Type of medicine An aromatase inhibitor hormone antagonist Used for Câncer de mama in women Also called Femara® Available as Tablets Letrozole is a hormonal breast cancer treatment. Some breast cancers need the hormone oestrogen to grow. In women who have been through.
Medicine leaflet
Exemestano para câncer de mama
These occur in up to 1 in 4 women... The side-effects will settle as your body adjusts to the medicine. About exemestane Type of medicine An aromatase inhibitor hormone antagonist Usado para Câncer de mama in women Also called Aromasin® Available as Tablets Exemestane is a hormonal breast cancer treatment. Some breast cancers need the hormone.
Patient information leaflet
Sintomas do câncer
Cancer symptoms will vary according to the type of cancer and how far the cancer has grown. What are cancer symptoms. Any unexplained lumps or bumps. You may also be asked about more specific features, depending on which underlying cancer is suspected such as: Breast cancer : breast lump, nipple discharge, change in skin. Bowel cancer : blood in.
Leitura adicional e referências
- Câncer de mama; MedlinePlus, National Library of Medicine.
- American Cancer Society: Cancer Facts and Statistics
- Apostolou P, Fostira F. Hereditary breast cancer: the era of new susceptibility genes. Biomed Res Int. 2013;2013:747318. doi: 10.1155/2013/747318. Epub 2013 Mar 21.
- Economopoulou P, Dimitriadis G, Psyrri A. Beyond BRCA: new hereditary breast cancer susceptibility genes. Cancer Treat Rev. 2015 Jan;41(1):1-8. doi: 10.1016/j.ctrv.2014.10.008. Epub 2014 Nov 6.
- Filippini SE, Vega A. Breast cancer genes: beyond BRCA1 and BRCA2. Front Biosci (Landmark Ed). 2013 Jun 1;18(4):1358-72. doi: 10.2741/4185.
- Foulkes WD. BRCA1 and BRCA2 - update and implications on the genetics of breast cancer: a clinical perspective. Clin Genet. 2014 Jan;85(1):1-4. doi: 10.1111/cge.12291. Epub 2013 Oct 25. No abstract available.
- National Cancer Institute: Genetics of Breast and Gynecologic Cancers (PDQ®)–Health Professional Version
- Njiaju UO, Olopade OI. Genetic determinants of breast cancer risk: a review of current literature and issues pertaining to clinical application. Breast J. 2012 Sep;18(5):436-42. doi: 10.1111/j.1524-4741.2012.01274.x.
- Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer. 1998 Sep 4 [updated 2026 Mar 25]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1247/
- Shiovitz S, Korde LA. Genetics of breast cancer: a topic in evolution. Ann Oncol. 2015 Jul;26(7):1291-9. doi: 10.1093/annonc/mdv022. Epub 2015 Jan 20.
- Tung N, Battelli C, Allen B, Kaldate R, Bhatnagar S, Bowles K, Timms K, Garber JE, Herold C, Ellisen L, Krejdovsky J, DeLeonardis K, Sedgwick K, Soltis K, Roa B, Wenstrup RJ, Hartman AR. Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel. Cancer. 2015 Jan 1;121(1):25-33. doi: 10.1002/cncr.29010. Epub 2014 Sep 3.
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