About trimipramine

Trimipramine belongs to a group of medicines called antidepressivos tricíclicos. It is prescribed for the treatment of depressão.

The exact cause of depression is not known. It can develop for no apparent reason or it may be triggered by a life event such as a relationship problem, bereavement, or illness. People with depression have a consistently low mood and other symptoms severe enough to interfere with normal day-to-day activities. Medicines like trimipramine can help to ease the symptoms caused by depression, such as sleep disturbance and a loss of appetite. Trimipramine is thought to work by interfering with certain brain chemicals (called neurotransmitters) which may be involved in causing the symptoms of depression.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking trimipramine it is important that your doctor knows:

• Se você está grávida ou amamentando.

• Se você tiver algum problema com o funcionamento do seu fígado.

• Se você teve problemas com constipação.

• Se você tiver alguma dificuldade para urinar, ou se já teve problemas de próstata.

• If you have any of the following conditions: epilepsy, diabetes (diabetes mellitus), increased pressure in your eye (glaucoma), an overactive thyroid gland, or a heart condition.

• Se você já teve um problema de saúde mental (em particular, transtorno bipolar ou psicose).

• If you have either of the following rare conditions: a tumour on your adrenal gland, called phaeochromocytoma, or an inherited blood disorder called porphyria.

• Se você estiver tomando qualquer outro medicamento. Isso inclui qualquer medicamento que esteja disponível para compra sem receita médica, bem como medicamentos fitoterápicos e complementares. É especialmente importante que você informe ao seu médico se recentemente tomou um medicamento para depressão, conhecido como inibidor da monoamina oxidase (IMAO).

• Se você já teve uma reação alérgica a um medicamento.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about trimipramine and will provide you with a full list of the side-effects which you could experience from taking it.

• It is usual to take trimipramine once a day, at bedtime. Some doctors, however, may recommend smaller doses taken two or three times a day. Your doctor will tell you which is right for you and the directions will also be printed on the label of the pack to remind you about what the doctor said to you.

• You can take trimipramine either with or without food. Swallow the tablet/capsule with a drink of water.

• Se você esquecer de tomar uma dose, tome-a assim que se lembrar (a menos que esteja quase na hora da próxima dose, nesse caso, pule a dose esquecida e tome a próxima dose normalmente). Não tome duas doses juntas para compensar uma dose esquecida.
  

• Tente manter suas consultas regulares com seu médico. Isso é para que seu médico possa verificar seu progresso.

• Take trimipramine exactly as your doctor tells you to. It can cause drowsiness so your doctor may advise you to take a small dose to begin with, and then that you gradually increase it as your body becomes used to the medicine.

• When you start taking trimipramine, you may feel that it is not working for you straightaway. It can take a week or so for the effect to build up and several weeks before you feel the full benefit. It is important that you do not stop taking it thinking it is not helping. Also, while you feel depressed, you may have distressing thoughts, and think about harming yourself or ending your life. If this happens, it is very important that you tell your doctor about it straightaway.

• Your doctor will recommend that you do not drink alcohol while you are on trimipramine. This is because it increases the risk of side-effects, such as feeling sleepy.

• If you buy any medicines 'over the counter', check with a pharmacist that they are suitable to take with trimipramine. This is because a number of medicines can increase the risk of side-effects from trimipramine, including some strong painkillers, flu remedies and antihistamines which can be bought from pharmacies.

• If you have diabetes you may need to check your blood sugar (glucose) more frequently. This is because trimipramine may affect the levels of sugar in your blood. Your doctor will advise you about this.

• A few people who take trimipramine find that their skin becomes more sensitive to sunlight than usual. Try to avoid strong sunlight until you know how your skin reacts, or use a sun cream with a high sun protection factor. Do not use sunbeds.

• There are several types of antidepressants - each type works in a slightly different way and can have different side-effects. If you find that trimipramine does not suit you then let your doctor know, as another antidepressant may be found that does.

• If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking trimipramine, as it can interfere with some anaesthetics.

• If you suspect that someone (especially if it is a child) might have taken trimipramine by accident, go to the accident and emergency department of your local hospital straightaway. This is very important because trimipramine can cause serious problems when it is taken accidentally or in overdose. Take the container with you to show what has been taken, even if the pack is now empty.

• Your doctor will ask you to carry on taking trimipramine even after you feel better. This is to help stop your depression from returning. It is normal for a course of treatment to last for around six months after your symptoms have eased.

• Continue to take trimipramine unless your doctor tells you otherwise. Stopping treatment suddenly can sometimes cause problems and your doctor will want you to reduce your dose gradually over a number of weeks when this becomes necessary.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with trimipramine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms which you think may be due to trimipramine, speak with your doctor or pharmacist for further advice.

• Mantenha todos os medicamentos fora do alcance e da vista das crianças.

• Armazene em local fresco e seco, longe de calor e luz diretos.