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Meperidine for pain relief

Demerol

This medicine is a strong opioid painkiller (narcotic analgesic). There is a serious risk of addiction when taking this medicine, especially if used long-term. If you have any questions or concerns about taking opioids safely please speak with your physician or a pharmacist.

Meperidine is used to relieve pain, particularly during childbirth.

It is usually given by injection and provides pain relief for up to four hours.

The most common side-effects are feeling dizzy or sleepy, sweating and nausea.

At a glance

  • Meperidine is a strong opioid painkiller also known as pethidine.

  • It is used for severe pain, including during childbirth.

  • Meperidine works on your nervous system and brain to reduce pain.

  • It can be given as tablets, liquid, or injections.

  • Do not drink alcohol, drive, or operate machinery if you feel dizzy or sleepy.

  • Long-term use can lead to dependence, causing withdrawal symptoms if stopped.

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About meperidine

Tipo de medicamento

A strong opioid painkiller (narcotic analgesic)

Usado para

Alívio da dor

Também chamado de

Demerol®

Disponível como

Comprimidos, medicamento líquido oral e injeção

Opioides fortes (narcotic analgesics) are medicines used to treat severe pain. Although there are a number of narcotic analgesics, meperidine (also known as pethidine) is the one that has been traditionally used during childbirth, as its effects are shorter-lasting than some of the others. It works on your nervous system and brain to reduce the amount of pain you feel. Meperidine can be taken by mouth as a tablet or liquid medicine, but during childbirth it is more usually given as an injection.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meperidine it is important that your physician knows:

  • If you are pregnant (other than during labor) or breastfeeding.

  • Se você tiver problemas no fígado ou nos rins.

  • Se você tiver problemas de próstata ou qualquer dificuldade para urinar.

  • Se você tiver algum problema respiratório, como asma ou doença pulmonar obstrutiva crônica (DPOC).

  • Se você foi informado de que tem pressão arterial baixa (hipotensão).

  • Se você tiver algum problema com sua tireoide ou glândulas suprarrenais.

  • Se você tem epilepsia.

  • Se você tiver um problema com seu ducto biliar.

  • Se você está constipado há mais de uma semana ou tem um problema inflamatório intestinal.

  • Se você tem uma condição que causa fraqueza muscular, chamada miastenia gravis.

  • Se você teve uma lesão grave na cabeça recentemente.

  • Se você já foi dependente de drogas ou álcool.

  • Se você já teve uma reação alérgica a um medicamento.

  • Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

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  • Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about meperidine and will provide you with a full list of the side-effects which you may experience from having it.

  • If you have been prescribed meperidine injection, this will be given to you by your physician or nurse. It will be injected under your skin or into a muscle. The injections can be repeated every few hours during labor, if needed. If you are being given meperidine for other types of pain (such as after surgery), the injection can be repeated every three to four hours.

  • If you have been prescribed meperidine tablets, take the tablets exactly as your physician has told you to. The usual dose of meperidine is between one and three 50 mg tablets.

  • If you have been prescribed meperidine oral liquid medicine, take the liquid exactly as your physician tells you to. Use a measuring cup or oral syringe to measure the correct amount of liquid. The measured dose should be mixed in half a glass of water before swallowing. This is because swallowing undiluted meperidine liquid can numb the mouth.

  • When taking meperidine by mouth, the dose should not be repeated more frequently than every three to four hours.

  • If you forget to take a dose, take it as soon as you remember and then continue taking your doses every three to four hours from that point. Do not take two doses together to make up for a forgotten dose.

  • Ask your physician for advice before drinking alcohol. Your physician may recommend that you do not drink alcohol for a while after you have had meperidine because it increases the possibility of side-effects such as feeling dizzy and sleepy.

  • If you are a driver, please be aware that meperidine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, you are advised to carry with you some evidence that the medicine has been prescribed for you - a prescription form or a patient information leaflet from the pack is generally considered suitable.

  • If you are planning a trip abroad and need to take meperidine with you, you are advised to carry a letter with you from your physician to explain why you have been prescribed it. This is because meperidine is classed as a 'controlled drug' and is subject to certain restrictions.

  • You will not be given meperidine tablets or liquid for longer than is necessary. This is because repeatedly using meperidine over a period of time can lead to your body becoming dependent on it. When you then stop taking it, it will cause withdrawal symptoms such as restlessness and irritability. If you are concerned about this, discuss it with your physician or pharmacist. This will not become a problem if you are receiving a dose or two of meperidine during labor.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with meperidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.

Common meperidine side-effects

O que posso fazer se passar por isso?

Náusea ou vômito

Stick to simple foods. Drink plenty of water to replace any lost fluids

Sentindo-se tonto, sonolento ou com sono

Se isso acontecer, não dirija e não use ferramentas ou máquinas. Não consuma álcool

Other common side-effects include headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, feeling confused, difficulties passing urine, shallow breathing

If any of these occur, speak with your physician

Se você sentir quaisquer outros sintomas que acha que podem ser devido a este medicamento, fale com seu médico ou farmacêutico.

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the Emergency Room of your local hospital. Take the container with you, even if it is empty.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

If you are having surgery or any dental treatment, tell the person carrying out the treatment which medicines you are taking.

Se você comprar qualquer medicamento, verifique com um farmacêutico se eles são adequados para tomar com seus outros medicamentos.

Não guarde medicamentos vencidos ou indesejados. Pergunte ao seu farmacêutico sobre maneiras de descartar medicamentos com segurança na sua área local.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

verificador de sintomas

Inseguro sobre misturar medicamentos?

Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.

Perguntas frequentes

What is meperidine and how does it help with pain?

Meperidine is a strong opioid painkiller, also known as pethidine. It is used to treat severe pain by working on your nervous system and brain to reduce how much pain you feel. It's often used during childbirth because its effects are shorter-lasting compared to some other strong opioids.

Are there any conditions that would prevent me from taking meperidine?

Yes, several conditions might make meperidine unsuitable or require extra care. These include liver or kidney problems, prostate issues, breathing difficulties like asthma or COPD, low blood pressure, problems with your thyroid or adrenal glands, epilepsy, a bile duct problem, persistent constipation, inflammatory bowel problems, myasthenia gravis, or a recent severe head injury. Your physician also needs to know if you are pregnant (other than during labor), breastfeeding, or have ever been dependent on drugs or alcohol.

How long do the effects of meperidine typically last when given as an injection during labour?

Meperidine injections can be repeated every few hours during labour, if needed. For other types of pain, such as after surgery, injections can be repeated every three to four hours.

What should I do if I forget to take a dose of meperidine tablets or liquid?

If you miss a dose, take it as soon as you remember. After that, continue taking your doses every three to four hours from that point. Do not take two doses together to compensate for a forgotten dose.

Can I drink alcohol while taking meperidine?

It is advised to ask your physician for advice before drinking alcohol. They may recommend avoiding alcohol for a period after taking meperidine, as it can increase side-effects like dizziness and sleepiness.

What are the common side-effects of meperidine, and what can I do about them?

Common side-effects include nausea, vomiting, dizziness, sleepiness, headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, confusion, difficulties passing urine, and shallow breathing. For nausea or vomiting, stick to simple foods and drink plenty of water. If you feel dizzy, sleepy, or drowsy, do not drive or use tools/machines, and avoid alcohol. For any troublesome or persistent side-effects, speak with your physician or pharmacist.

Is it safe to drive after taking meperidine?

Meperidine is likely to affect your reactions and ability to drive. It is illegal to drive if your reactions are impaired. If you must drive, it's advisable to carry proof of its prescription, like a prescription form or patient information leaflet, as meperidine is a controlled drug.

Leitura adicional e referências

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

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