Meperidina para alívio da dor
Demerol
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 27 Fev 2023
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This medicine is a strong opioid painkiller (narcotic analgesic). There is a serious risk of addiction when taking this medicine, especially if used long-term. If you have any questions or concerns about taking opioids safely please speak with your physician or a pharmacist.
Meperidine is used to relieve pain, particularly during childbirth.
It is usually given by injection and provides pain relief for up to four hours.
The most common side-effects are feeling dizzy or sleepy, sweating and nausea.
Em resumo
Meperidine is a strong opioid painkiller also known as pethidine.
It is used for severe pain and can be given as tablets, liquid, or injection.
It is commonly used during childbirth because its effects are shorter-lasting.
Do not drink alcohol or drive after taking meperidine.
Tell your doctor about existing conditions or other medicines you are taking.
Repeated use can lead to dependence.
Common side-effects include nausea, dizziness, constipation, and headache.
About meperidine
Tipo de medicamento | A strong opioid painkiller (narcotic analgesic) |
Usado para | Alívio da dor |
Também chamado de | Demerol® |
Disponível como | Comprimidos, medicamento líquido oral e injeção |
Opioides fortes (narcotic analgesics) are medicines used to treat severe pain. Although there are a number of narcotic analgesics, meperidine (also known as pethidine) is the one that has been traditionally used during childbirth, as its effects are shorter-lasting than some of the others. It works on your nervous system and brain to reduce the amount of pain you feel. Meperidine can be taken by mouth as a tablet or liquid medicine, but during childbirth it is more usually given as an injection.
Before having meperidine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking meperidine it is important that your physician knows:
If you are pregnant (other than during labor) or breastfeeding.
Se você tiver problemas no fígado ou nos rins.
Se você tiver problemas de próstata ou qualquer dificuldade para urinar.
Se você tiver algum problema respiratório, como asma ou doença pulmonar obstrutiva crônica (DPOC).
Se você foi informado de que tem pressão arterial baixa (hipotensão).
Se você tiver algum problema com sua tireoide ou glândulas suprarrenais.
Se você tem epilepsia.
Se você tiver um problema com seu ducto biliar.
Se você está constipado há mais de uma semana ou tem um problema inflamatório intestinal.
Se você tem uma condição que causa fraqueza muscular, chamada miastenia gravis.
Se você teve uma lesão grave na cabeça recentemente.
Se você já foi dependente de drogas ou álcool.
Se você já teve uma reação alérgica a um medicamento.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
How meperidine is given
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about meperidine and will provide you with a full list of the side-effects which you may experience from having it.
If you have been prescribed meperidine injection, this will be given to you by your physician or nurse. It will be injected under your skin or into a muscle. The injections can be repeated every few hours during labor, if needed. If you are being given meperidine for other types of pain (such as after surgery), the injection can be repeated every three to four hours.
If you have been prescribed meperidine tablets, take the tablets exactly as your physician has told you to. The usual dose of meperidine is between one and three 50 mg tablets.
If you have been prescribed meperidine oral liquid medicine, take the liquid exactly as your physician tells you to. Use a measuring cup or oral syringe to measure the correct amount of liquid. The measured dose should be mixed in half a glass of water before swallowing. This is because swallowing undiluted meperidine liquid can numb the mouth.
When taking meperidine by mouth, the dose should not be repeated more frequently than every three to four hours.
If you forget to take a dose, take it as soon as you remember and then continue taking your doses every three to four hours from that point. Do not take two doses together to make up for a forgotten dose.
Obtendo o máximo do seu tratamento
Ask your physician for advice before drinking alcohol. Your physician may recommend that you do not drink alcohol for a while after you have had meperidine because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that meperidine is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, you are advised to carry with you some evidence that the medicine has been prescribed for you - a prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are planning a trip abroad and need to take meperidine with you, you are advised to carry a letter with you from your physician to explain why you have been prescribed it. This is because meperidine is classed as a 'controlled drug' and is subject to certain restrictions.
You will not be given meperidine tablets or liquid for longer than is necessary. This is because repeatedly using meperidine over a period of time can lead to your body becoming dependent on it. When you then stop taking it, it will cause withdrawal symptoms such as restlessness and irritability. If you are concerned about this, discuss it with your physician or pharmacist. This will not become a problem if you are receiving a dose or two of meperidine during labor.
Can meperidine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with meperidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common meperidine side-effects | O que posso fazer se passar por isso? |
Náusea ou vômito | Stick to simple foods. Drink plenty of water to replace any lost fluids |
Sentindo-se tonto, sonolento ou com sono | Se isso acontecer, não dirija e não use ferramentas ou máquinas. Não consuma álcool |
Other common side-effects include headache, dry mouth, constipation, feeling flushed, itchy skin rash, sweating, feeling confused, difficulties passing urine, shallow breathing | If any of these occur, speak with your physician |
Se você sentir quaisquer outros sintomas que acha que podem ser devido a este medicamento, fale com seu médico ou farmacêutico.
How to store meperidine
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the Emergency Room of your local hospital. Take the container with you, even if it is empty.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
If you are having surgery or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Se você comprar qualquer medicamento, verifique com um farmacêutico se eles são adequados para tomar com seus outros medicamentos.
Não guarde medicamentos vencidos ou indesejados. Pergunte ao seu farmacêutico sobre maneiras de descartar medicamentos com segurança na sua área local.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is the difference between meperidine and other strong opioid painkillers?
Meperidine is a strong opioid painkiller, similar to others in its class, but it has traditionally been used during childbirth because its effects are shorter-lasting compared to some other strong opioids. It works by acting on your nervous system and brain to decrease the amount of pain you feel.
How long do the effects of a meperidine injection last?
If you receive a meperidine injection, it can be repeated every few hours during labor if needed. For other types of pain, such as after surgery, the injection can be repeated every three to four hours. This indicates that its effects last for a few hours.
Are there any specific instructions for taking meperidine liquid medicine?
Yes, if you are prescribed meperidine oral liquid medicine, you should use a measuring cup or oral syringe to accurately measure the dose. This measured dose must then be mixed in half a glass of water before you swallow it. Swallowing the liquid undiluted can cause numbness in your mouth.
Why can't meperidine be used for a long time?
Meperidine tablets or liquid are not typically given for extended periods because repeated use over time can lead to your body becoming dependent on it. If you stop taking it after prolonged use, you could experience withdrawal symptoms like restlessness and irritability. This is generally not an issue if you receive only one or two doses during labor.
What should I do if I forget to take a dose of meperidine?
If you forget to take a dose of meperidine, you should take it as soon as you remember. After that, continue taking your subsequent doses every three to four hours from that point. It is important not to take two doses together to compensate for a missed dose.
Will meperidine affect my ability to drive?
Yes, meperidine is likely to affect your reactions and ability to drive. It is an offense to drive while your reactions are impaired. Even if you believe your driving ability is not impaired, it's advisable to carry evidence that the medicine has been prescribed for you, such as a prescription form or a patient information leaflet.
Is it safe to travel internationally with meperidine?
If you plan to travel abroad and need to take meperidine with you, it's recommended to carry a letter from your physician. This is because meperidine is classified as a 'controlled drug' and may be subject to certain restrictions in different countries.
Leitura adicional e referências
- FDA Drug Label, Demerol® 50 mg and 100 mg Tablets; Validus Pharmaceuticals LLC, DailyMed, National Institutes of Health, US National Library of Medicine. Dated March 2021.
- FDA Drug Label, Meperidine 50 mg/5 ml Oral Solution (50 mg and 100 mg Tablets); Boehringer Ingelheim, DailyMed, National Institutes of Health, US National Library of Medicine. Dated May 2006.
- FDA Drug Label, Meperidine 25 mg/ml, 50 mg/ml, 100 mg/ml Injection; Hikma Pharmaceuticals USA Inc., DailyMed, National Institutes of Health, US National Library of Medicine. Dated April 2022.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão agendada: 26 de agosto de 2027
27 Fev 2023 | Última versão
1 Mar 2017 | Publicado originalmente
Escrito por:
Michael Stewart, MRPharmS

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