Intervertebral disc disease
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Intervertebral disc disease is a common condition characterised by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.
Descrição
Intervertebral disc disease is a common condition characterised by the breakdown (degeneration) of one or more of the discs that separate the bones of the spine (vertebrae), causing pain in the back or neck and frequently in the legs and arms. The intervertebral discs provide cushioning between vertebrae and absorb pressure put on the spine.
While the discs in the lower (lumbar) region of the spine are most often affected in intervertebral disc disease, any part of the spine can have disc degeneration. Depending on the location of the affected disc or discs, intervertebral disc disease can cause periodic or chronic pain in the back or neck. Pain is often worse when sitting, bending, twisting, or lifting objects.
Degenerated discs are prone to out-pouching (herniation); the protruding disc can press against one of the spinal nerves that run from the spinal cord to the rest of the body. This pressure causes pain, weakness, and numbness in the back and legs. Herniated discs often cause nerve pain called sciatica that travels along the sciatic nerve, which runs from the lower back down the length of each leg.
As a disc degenerates, small bony outgrowths (bone spurs) may form at the edges of the affected vertebrae. These bone spurs may pinch (compress) the spinal nerves, leading to weakness or numbness in the arms or legs. If the bone spurs compress the spinal cord, affected individuals can develop problems with walking and bladder and bowel control. Over time, a degenerating disc may break down completely and leave no space between vertebrae, which can result in impaired movement, pain, and nerve damage.
Padrões de herança
The source lists the following possible inheritance patterns: Pattern unknown. More than one pattern can apply in different cases.
Related genes
Other names
Discogenic disease
Discogenic disorder
Disorder of intervertebral disc
IDD
Intervertebral disc degeneration
Intervertebral disc disorder
Intervertebral disk degeneration
Related patient information and medicines
Patient information leaflet
Problemas nos discos da coluna
Spinal discs are also called intervertebral discs. There is a spinal disc between each bone (vertebra) in your spine. This keeps the vertebrae separated and acts as a shock absorber. As we get older the spinal discs gradually become damaged and this can cause problems such as back pain. Other problems affecting the spinal discs include a slipped.
Patient information leaflet
Hérnia de disco
A deslizamento de disco is an old-fashioned term and does not truly describe what happens in this condition. It is more common to refer to it as a "disc prolapse", "disc herniation" or "disc bulge". However this leaflet will continue to use the term "slipped disc" due to its common usage. A slipped disc often causes sudden severe lower back pain. The disc.
Patient information leaflet
Doença de Paget do osso
Paget's disease of bone affects the structure of parts of one or more bones. In most cases it causes no symptoms and does not need treatment. Symptoms develop in some cases and pain in the affected part of bone is the most common symptom. What is Paget's disease of bone. Doença de Paget do osso was first described by Sir James Paget in 1877. (It.
Patient information leaflet
Doença dos Legionários
Doença dos Legionários is a serious lung infection (pneumonia) with chills, high temperature (fever) and tensão muscular pains. You get the infection by breathing in droplets of water which contain legionella germs (bacteria) from... Punção lombar Sometimes a punção lombar (sometimes called a spinal tap) is performed to help diagnosis. Here, a sample of.
Patient information leaflet
Medicamentos antirreumáticos modificadores da doença
Disease-modifying antirheumatic drugs (DMARDs) are medicines that are normally prescribed as soon as artrite reumatoide (AR) is diagnosed, in order to reduce damage to the joints. Rarely, they can have serious side-effects affecting the blood, liver... Disease-modifying antirheumatic drugs (DMARDs) are a group of medicines that are used to ease.
Patient information leaflet
Doença celíaca
Doença celíaca (also spelled celiac disease) mainly affects the part of the gut called the small intestine. It can occur at any age. Coeliac disease is caused by a reaction of the gut to gluten. (For this reason it is sometimes also called gluten-sensitive enteropathy). Symptoms go if you do not eat any foods that contain gluten. What is coeliac.
Leitura adicional e referências
- Intervertebral disc disease; MedlinePlus, National Library of Medicine.
- Feng Y, Egan B, Wang J. Genetic Factors in Intervertebral Disc Degeneration. Genes Dis. 2016 Sep;3(3):178-185. doi: 10.1016/j.gendis.2016.04.005. Epub 2016 Apr 23.
- Hanaei S, Abdollahzade S, Khoshnevisan A, Kepler CK, Rezaei N. Genetic aspects of intervertebral disc degeneration. Rev Neurosci. 2015;26(5):581-606. doi: 10.1515/revneuro-2014-0077.
- Ikegawa S. The genetics of common degenerative skeletal disorders: osteoarthritis and degenerative disc disease. Annu Rev Genomics Hum Genet. 2013;14:245-56. doi: 10.1146/annurev-genom-091212-153427.
- Janeczko L, Janeczko M, Chrzanowski R, Zielinski G. The role of polymorphisms of genes encoding collagen IX and XI in lumbar disc disease. Neurol Neurochir Pol. 2014 Jan-Feb;48(1):60-2. doi: 10.1016/j.pjnns.2013.04.001. Epub 2014 Jan 23.
- Kalb S, Martirosyan NL, Kalani MY, Broc GG, Theodore N. Genetics of the degenerated intervertebral disc. World Neurosurg. 2012 Mar-Apr;77(3-4):491-501. doi: 10.1016/j.wneu.2011.07.014. Epub 2011 Nov 7.
- Kepler CK, Ponnappan RK, Tannoury CA, Risbud MV, Anderson DG. The molecular basis of intervertebral disc degeneration. Spine J. 2013 Mar;13(3):318-30. doi: 10.1016/j.spinee.2012.12.003. Epub 2013 Feb 8.
- Toktas ZO, Eksi MS, Yilmaz B, Demir MK, Ozgen S, Kilic T, Konya D. Association of collagen I, IX and vitamin D receptor gene polymorphisms with radiological severity of intervertebral disc degeneration in Southern European Ancestor. Eur Spine J. 2015 Nov;24(11):2432-41. doi: 10.1007/s00586-015-4206-5. Epub 2015 Sep 5.
- Zhang Y, Sun Z, Liu J, Guo X. Advances in susceptibility genetics of intervertebral degenerative disc disease. Int J Biol Sci. 2008 Sep 2;4(5):283-90. doi: 10.7150/ijbs.4.283.
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