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Solução oral de Metadona

Metharose, Physeptone

Este medicamento é um analgésico opioide. Existe um risco sério de dependência ao tomar este medicamento, especialmente se usado a longo prazo. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued nova orientação para pessoas com prescrição de analgésico opioide. Se você tiver alguma dúvida ou preocupação sobre como tomar opioides com segurança, por favor, fale com seu médico ou farmacêutico.

Methadone oral solution is a substitute for street drugs like heroin which cause dependence and addiction.

It is important for you to continue to take methadone regularly, every day.

You are more likely to succeed in staying off heroin if you have support. Please ask about what counselling and help are available in your area.

At a glance

  • Methadone is a medicine used to treat opioid dependence and addiction.

  • It helps prevent withdrawal symptoms and is usually taken once daily as an oral liquid.

  • You will be supervised when you first start taking methadone to ensure correct dosage.

  • Do not drink alcohol or take street drugs with methadone due to increased overdose risk.

  • Do not stop taking methadone without discussing it with your doctor.

  • If you suspect an overdose, seek immediate medical help.

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About methadone

Tipo de medicamento

An opioid substitution therapy

Usado para

To help manage opioid dependence and addiction in adults (such as heroin addiction)

Também chamado de

Metharose®, Physeptone®

Disponível como

Oral solution, tablets

Methadone is prescribed to help you keep off drogas ilícitas such as heroína. It can help to prevent the unpleasant withdrawal symptoms which can occur when you stop using drugs like these. It is taken by mouth as an oral liquid and it works as a substitution treatment. Many people choose to stay on methadone long-term, although some people gradually reduce their dose and come off it.

The effects of methadone last longer than heroin so it is usually prescribed as a once-daily dose. To begin with, you will usually be asked to take it under the supervision of the person who dispenses the methadone to you. This means there can be no doubt about how much methadone you take at each dose. This supervision may be relaxed after a few months of you taking a regular maintenance dose.

Methadone also acts as a painkiller. It is occasionally used to treat severe pain if other strong painkillers are unsuitable. If you have been prescribed methadone for this reason then you should speak with your doctor or home-care team if you have any questions about your treatment. This document gives information about methadone when it is used to manage drug addiction only.

To make sure that this is the right treatment for you, before you start taking methadone it is important that your doctor or pharmacist knows:

  • Se você está grávida ou amamentando.

  • Se você tiver problemas de próstata ou qualquer dificuldade para urinar.

  • Se você tiver algum problema respiratório, como asma ou doença pulmonar obstrutiva crônica (DPOC).

  • If you have been told you have low blood pressure or an unusual heart rhythm.

  • Se você tiver algum problema com sua tireoide ou glândulas suprarrenais.

  • If you have fits or epilepsy.

  • Se você tiver um problema com o funcionamento do seu fígado ou um problema com o funcionamento dos seus rins.

  • Se você tiver um problema com seu ducto biliar.

  • Se você está constipado há mais de uma semana ou tem um problema inflamatório intestinal.

  • Se você tem uma condição que causa fraqueza muscular, chamada miastenia gravis.

  • Se você teve uma lesão grave na cabeça recentemente.

  • Se você já teve uma reação alérgica a um medicamento.

  • Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

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  • Carefully follow the advice your doctor has given to you and read any printed information you have been given. The manufacturer's printed information leaflet (which will be supplied with the medicine) will give you more information about methadone and will provide you with a full list of the side-effects which you could experience from taking it.

  • Take methadone exactly as your doctor tells you to. Do not take more, or less, than the dose you have been prescribed. It is usually prescribed as a once-daily dose

  • Try to take your dose at the same time of day, each day. Initially you will be asked to take methadone where you can be supervised. This is to help you stick with your treatment and make sure you do not miss any doses.

  • At first your doctor will prescribe a low-ish dose and then see you frequently to adjust this to a regular maintenance dose. This early stage is very important because too high a dose can cause you serious harm, so please be patient. It may take a few weeks until the correct dose is found and you may have some minor withdrawal symptoms during this time. The correct dose varies from person to person, depending on how much heroin you were using and how your body deals with (metabolises) methadone.

  • If you miss a dose, wait until it is time for your next dose and take this next dose when it is due. Do confiar take two doses together to make up for a missed dose. It is important that you tell your doctor you have missed a dose. If you miss more than three days of methadone, your dose will need to be changed.

  • It is important that you keep your regular appointments with your doctor/clinic so that your progress can be reviewed. You will be asked to give a urine sample from time to time.

  • You are more likely to succeed in staying off heroin if you have support and counselling. Local drug community teams, self-help groups and other agencies can be of help. It is much harder to 'do it alone', so go for counselling and help if it is available in your area.

  • Methadone causes drowsiness and will affect your ability to drive. It is against the law to drive if your driving ability is impaired by this medicine. Even if your driving is not impaired, you will be guilty of an offence unless the methadone has been prescribed for a medical reason e it has been taken according to the instructions given by the prescriber.

  • Do not take more than the dose your doctor has prescribed for you. Signs of overdose can include pinpoint pupils, shallow breathing and, eventually, unconsciousness. If you suspect that you or someone else might have had an overdose of methadone, contact a doctor or go to the accident and emergency department of a local hospital straightaway. Take the container with you, even if it is empty.

  • You should not take any street drugs or drink alcohol while you are on methadone. This is because other street drugs and/or alcohol can increase the risk of overdose and side-effects.

  • Methadone (even in small amounts) is a special hazard to children and other people if it is swallowed by accident. If you suspect that someone else has swallowed some methadone, please get medical help straightaway.

  • Do not stop taking methadone without discussing this with your doctor or drug-team worker first. It is important that methadone should be taken regularly to reduce the risk of withdrawal symptoms from occurring. Withdrawal symptoms from methadone are similar to those from heroin (they are less severe but last longer). When you are ready to consider becoming drug-free, your doctor or drug-team worker will be able to help you decide on the best way to do this in order to keep withdrawal effects to a minimum.

  • If you buy any medicines, please check with a pharmacist that they are safe to take with methadone.

  • If you are having an operation or dental treatment, please tell the person carrying out the treatment that you are taking methadone. It could interfere with an anaesthetic, if needed.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with methadone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common methadone side-effects

O que posso fazer se passar por isso?

Sentindo-se mal (náusea) ou vomitando, dor de barriga (abdominal)

Mantenha-se em refeições simples - evite alimentos ricos ou picantes

Constipação

Coma uma dieta equilibrada e beba bastante água todos os dias

Feeling dizzy, faint or sleepy

Não dirija e não use ferramentas ou máquinas. Não consuma álcool

Boca seca

Tente mascar chiclete sem açúcar ou chupar balas sem açúcar

Other effects include: difficulty passing urine, mood changes, flushing, hypothermia, slow heartbeat, dry eyes and feeling restless

If any of these become particularly troublesome, speak with your doctor

Importante: pessoas que tomam analgésicos opioides, e seus familiares e amigos, devem estar cientes do risco de overdose acidental e saber quando procurar ajuda médica. O risco é maior se você também tomar outros medicamentos que causam sonolência. Sinais de que você tomou muito medicamento incluem:

  • Sentindo-se muito sonolento ou tonto.

  • Sentindo-se mal (náusea) ou vomitando (vômito).

  • Dificuldades respiratórias.

  • Perda de consciência.

Se você tomou mais medicação do que deveria ou se outra pessoa acidentalmente ingerir seu medicamento, chame uma ambulância e informe o nome do seu remédio.

If you experience any other symptoms which you think may be due to methadone, please speak with your doctor, clinic or pharmacist for further advice.

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

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Perguntas frequentes

How does methadone help stop heroin withdrawal symptoms?

Methadone is prescribed to help manage opioid dependence and addiction by preventing the unpleasant withdrawal symptoms that can occur when you stop using drugs like heroin. It works as a substitution treatment and its effects last longer than heroin, so it is usually taken once daily.

Why is methadone supervision necessary, and will it always be required?

Initially, you will usually be asked to take methadone under supervision, meaning someone will dispense it to you. This is to ensure the correct dose is taken and to help you stick with your treatment. This supervision may be relaxed after a few months once you are on a regular maintenance dose.

What should I do if I miss a dose of methadone?

If you miss a dose, you should wait until it's time for your next scheduled dose and take that dose as usual. Do not take two doses together to compensate for the missed one. It's important to tell your doctor if you miss a dose. If you miss more than three days of methadone, your dose will need to be adjusted by your doctor.

Can I drive while taking methadone?

Methadone can cause drowsiness and will affect your ability to drive. It is against the law to drive if this medicine impairs your driving ability. Even if your driving is not impaired, you could be committing an offence unless the methadone has been prescribed for a medical reason and you have taken it according to your prescriber's instructions.

What are the risks of taking other street drugs or alcohol with methadone?

You should not take any street drugs or drink alcohol while on methadone. Doing so can increase the risk of overdose and worsen side-effects. Always avoid mixing methadone with other substances.

What should I do if someone accidentally swallows my methadone?

Methadone, even in small amounts, poses a significant hazard if swallowed by children or other people. If you suspect that someone else has swallowed methadone, you must get medical help straightaway.

What if I experience side-effects like feeling sick, constipation, or dizziness?

Many common side-effects improve as your body adjusts to methadone. If you feel sick or are being sick, try to stick to simple meals and avoid rich or spicy foods. For constipation, eat a well-balanced diet and drink plenty of water. If you feel dizzy, faint, or sleepy, do not drive or operate machinery, and avoid alcohol. If any side-effects continue or become troublesome, speak with your doctor or pharmacist.

How long will it take to find the correct dose of methadone for me?

Initially, your doctor will prescribe a low dose and will see you frequently to adjust it to a regular maintenance dose. This early stage is crucial because too high a dose can be dangerous. It may take a few weeks until the correct dose is found, and you might experience some minor withdrawal symptoms during this period. The correct dose is unique to each person, depending on their previous heroin use and how their body processes methadone.

What should I do if I need an operation or dental treatment while on methadone?

If you are having an operation or dental treatment, it is very important to tell the person carrying out the treatment that you are taking methadone. This is because methadone could interfere with an anaesthetic if one is needed.

Leitura adicional e referências

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

About the reviewer

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Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • Próxima revisão prevista para: 12 de setembro de 2027
  • 14 Set 2024 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani
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