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Comprimidos de Lofexidina

BritLofex, Lucemyra

Nota do autor clínico Michael Stewart 01/03/2022: BritLofex® tablets were discontinued in the UK in October 2018. At the time of review there are no branded or generic products containing lofexidine available in the UK. Lofexidine may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.

It is usual to take four tablets over the first day. Your dose will then be increased over the next few days to suit your needs. A course of treatment usually lasts 7-10 days.

The main side-effects are dizziness, dry mouth and feeling sleepy.

At the end of your treatment your dose will be reduced gradually over a few days. Do not stop taking lofexidine suddenly, as this can cause your blood pressure to rise suddenly which could be harmful.


Em resumo

  • Lofexidine is used to reduce withdrawal symptoms during opioid detoxification.

  • It helps to reduce effects like chills, sweating, stomach cramps, and muscle pain.

  • Take lofexidine exactly as your doctor tells you, usually for around 7-10 days.

  • Do not stop taking it suddenly, as your doctor will reduce your dose gradually.

  • Common side effects include feeling dizzy or sleepy, dry mouth, slow heart rate, and low blood pressure.

About lofexidine

Tipo de medicamento

An alpha-adrenergic agonist medicine

Usado para

Reducing withdrawal symptoms during opioid detoxification (such as heroin, morphine or dihydrocodeine detox)

Também chamado de

Lucemyra® (USA), BritLofex® (UK - discontinued)

Disponível como

Comprimidos

Lofexidine is a treatment for opioid drug dependence. Medicines for drug dependence are mainly used to reduce or prevent withdrawal symptoms while trying to break drug use.

Lofexidine is usually used alongside, but sometimes instead of, other medicines taken for opioid drug dependence such as methadone or buprenorphine. It helps to reduce withdrawal effects such as chills, sweating, stomach cramps, muscle pain, difficulties sleeping and runny nose.

Before taking lofexidine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking lofexidine it is important that your doctor knows:

  • Se você está grávida ou amamentando.

  • If you have a heart condition, or if you have had a heart attack, or if you have a heart rhythm problem such as a slow or irregular heartbeat.

  • Se você tem pressão baixa.

  • If you have had a stroke or 'mini-stroke' (also known as a transient ischaemic attack, or TIA).

  • If you are feeling depressed.

  • Se você tiver algum problema com o funcionamento dos seus rins.

  • Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

  • Se você já teve uma reação alérgica a um medicamento.

How to take lofexidine

  • Lofexidine is used as part of a detoxification programme. Because each programme is tailored to meet a person's individual needs and no two detoxifications are exactly the same, it is important that you take lofexidine exactly as your doctor tells you to.

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about lofexidine, and will also provide you with a full list of the side-effects which you could experience from taking it.

  • Your doctor or community drug-team worker will tell you when and how often to take the tablets. It is likely that you will be asked to take four tablets over the course of the first day. Take your last dose of the day at bedtime, as this will help to reduce any problems you may have sleeping. Your dose may then be increased over the next few days. The maximum number of tablets you will be prescribed to take at any one time is 4, and the maximum number of tablets during any one day is 12.

  • You can take lofexidine tablets either before or after meals. Swallow the tablets whole with a drink of water.

  • If you forget to take a dose, take it as soon as you remember and then continue as before. Do not take two doses together to make up for a missed dose.

  • It is usual to take lofexidine for around 7-10 days, although sometimes a course of treatment can be for longer than this. You should not stop taking lofexidine suddenly, as this can cause your blood pressure to rise quickly which could be harmful. At the end of the treatment, your doctor will ask you to reduce your dose gradually over a few days to prevent this from happening.

Obtendo o máximo do seu tratamento

  • It is important that you keep your regular appointments with your doctor/clinic so that your progress can be reviewed. Your blood pressure and pulse rate will need to be regularly monitored (especially in the first few days) to make sure you are taking a dose which helps your condition but avoids unwanted symptoms.

  • Lofexidine will help you to deal with withdrawal symptoms but it will not help you through cravings. You are more likely to succeed in breaking your drug habit if you have support and counselling. Local drug community teams, self-help groups and other agencies can be of help. It is much harder to 'do it alone', so go for counselling and help if it is available in your area. Try to stay positive and relaxed, drink plenty of fluids, and eat a light diet.

  • You should not drink alcohol while you are on lofexidine because it can increase side-effects such as feeling sleepy or dizzy.

Can lofexidine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with lofexidine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common lofexidine side-effects (these affect more than 1 in 10 people)

O que posso fazer se passar por isso?

Sentindo-se tonto ou sonolento

If you feel dizzy, sit down for a while until you feel better. It is important you do not drive and do not use tools or machines while affected. Do not drink alcohol

Dry mouth and throat

Tente mascar chiclete sem açúcar ou chupar balas sem açúcar

Slow heart rate, low blood pressure

Seu médico verificará isso

Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, fale com seu médico ou farmacêutico para mais conselhos.

How to store lofexidine

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Informações importantes sobre todos os medicamentos

Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.

Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.

Se você comprar qualquer medicamento, verifique com um farmacêutico se é seguro tomá-lo com seus outros medicamentos.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Nunca guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

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Inseguro sobre misturar medicamentos?

Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.

Perguntas frequentes

Can I drive or operate machinery while taking lofexidine?

Lofexidine can cause dizziness and sleepiness. If you experience these side-effects, you should not drive or use tools or machines. It's best to sit down until you feel better.

What should I do if I forget to take a dose of lofexidine?

If you miss a dose, take it as soon as you remember. After that, continue with your regular schedule. Do not take a double dose to compensate for the one you missed.

How long will I typically need to take lofexidine?

You will usually take lofexidine for about 7 to 10 days, although sometimes a course of treatment might last longer. Your doctor will advise you on the exact duration for your individual detoxification programme.

What kind of support can help me during my detoxification in addition to lofexidine?

While lofexidine helps with withdrawal symptoms, it doesn't address cravings. You are more likely to succeed by seeking support and counselling. Local drug community teams, self-help groups, and other agencies can provide assistance. It's recommended to accept counselling and help if available in your area.

What if I experience a dry mouth or throat while taking lofexidine?

If you experience a dry mouth or throat, you can try chewing sugar-free gum or sucking on sugar-free sweets to help alleviate this symptom.

Are there any specific dietary recommendations while taking lofexidine?

It is advised to maintain a light diet. Also, ensure you drink plenty of fluids to stay hydrated during your treatment.

Leitura adicional e referências

Sobre o autorVer biografia completa

Imagem do autor

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

Sobre o revisor

Imagem do autor

Sid Dajani

Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • Next review due: 11 Feb 2028
  • 11 Fev 2025 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani
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