Comprimidos e injeção de ácido ibandrônico
Bondronat, Bonviva
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 23 Nov 2022
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Take ibandronic acid tablets first thing after you get up in the morning. Swallow the tablet whole with a large glass of plain water, at least half an hour before you have breakfast (or one hour before breakfast if you are taking Bonviva® tablets). Remain sitting or standing upright for at least 60 minutes after taking the tablet.
Each time you collect a prescription, make sure you have been given the same brand of tablet as before. This is because there are different brands of ibandronic acid tablets and not all are used for the same condition.
If you buy any medicines or supplements 'over the counter', make sure your pharmacist knows that you are taking a bisphosphonate medicine, as some medicines will prevent ibandronic acid from working properly.
A boa higiene bucal é particularmente importante com este tratamento - isso significa que você deve escovar os dentes regularmente e fazer check-ups dentários de rotina.
Em resumo
Ibandronic acid is a bisphosphonate medicine for bone conditions.
It is used to strengthen bones and reduce calcium levels in some cancers.
For osteoporosis, it is prescribed for post-menopausal women to prevent bone damage.
Tablets must be taken first thing in the morning with water, before food.
Stay upright for 60 minutes after taking tablets and avoid food/drink for 30-60 minutes.
Good dental hygiene is important, and dental treatment may need to be considered.
Report any thigh, hip, or groin pain, or jaw/ear problems to your doctor immediately.
About ibandronic acid
Tipo de medicamento | A bisphosphonate |
Usado para | Reducing bone damage in people with breast cancer that has spread to the bone; to reduce high levels of calcium in the blood caused by cancer (injection only); as a treatment for osteoporosis |
Também chamado de | Ibandronate sodium (in US) 50 mg tablets (for bone problems in breast cancer): Bondronat®; Iasibon®150 mg tablets (for osteoporosis): Bonviva®; Quodixor® Injection for infusion: Bondronat® |
Disponível como | Comprimidos e injeção |
The bisphosphonate medicine called ibandronic acid is prescribed for the treatment of three different conditions, all of which affect the bones. It is used as a treatment to reduce bone damage in people with breast cancer that has spread to the bone, and it is also used in people with cancer who have a high amount of calcium in their blood. It is also sometimes prescribed as a treatment to prevent further bone damage in women who have 'thinning' of the bones, a condition called osteoporose.
In some cancers there can be an excessive breakdown of bone. As this happens, the bone is weakened and calcium is lost from the bone and seeps into the blood, leading to higher-than-normal blood levels of calcium. Ibandronic acid helps by binding to bone, making the bone stronger and reducing the amount of calcium leaving the bone.
When ibandronic acid is used to treat osteoporosis, it is only suitable for women who have been through the menopause. Osteoporosis is a bone disease which causes bones to become brittle and fragile, making them prone to breaks and fractures. As we become older, our bone begins to lose density because old bone is lost faster than new bone can replace it. Women in particular have an increased risk of developing osteoporosis because they lose bone material rapidly after the menopause. Ibandronic acid slows down the rate at which old bone is lost. New bone continues to be made and this leads to an overall increase in bone density, which reduces the risk of broken bones and fractures.
Ibandronic acid is often prescribed in tablet form, but it is also sometimes prescribed as an injection administered over a short period of time (usually ranging from 15 minutes to 2 hours). If you are prescribed it as an injection, it will be given to you by a doctor or nurse in a hospital clinic.
Before taking ibandronic acid
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you have ibandronic acid it is important that your doctor knows:
Se você está grávida ou amamentando.
If you have any difficulties swallowing, or if you have a digestion problem.
If you are due to have any dental treatment in the near future, or if you have confiar recently had a dental check-up.
If you have any problems with the way your kidneys work, or if you have a heart condition.
If you are unable to sit upright for at least 60 minutes.
Se você foi informado de que tem baixos níveis de cálcio no sangue.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
How to take ibandronic acid
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ibandronic acid, and it will also provide you with a full list of the side-effects which you could experience from taking it. Not all brands of tablet are used to treat each of the conditions mentioned in this leaflet.
If you are taking 50 mg tablets (for bone problems in breast cancer): the usual dose is one 50 mg tablet each morning, although you may be asked to take it less frequently than this if you have any problems with the way your kidneys work. If on any day you forget to take a tablet, do not take the tablet at another time - just take the tablet due on the following day as usual. Do confiar take two tablets on the same day to make up for a missed dose.
If you are taking 150 mg tablets (for osteoporosis): the usual dose is one 150 mg tablet, once a month. You must take your dose on the same day of each month, so choose a day that best suits your routine. If you forget to take a dose on your usual day, take it on the morning after you remember. (If when you remember, your next dose is due within the next seven days then you should not take the missed tablet, just take your next dose when it is due.)
Taking ibandronic acid tablets
It is important that you take each tablet of ibandronic acid in the correct way, as otherwise they can cause irritation and damage as they are swallowed.
Take the tablet first thing in the morning, before you eat any food or have anything to drink other than water. You should also make sure it is more than six hours since you last ate food on the previous day.
Swallow the tablet whole - you must confiar chew, break, or crush the tablet. You must drink a large glassful of water as you take the tablet, and it is important that you take the tablet while you are standing up or sitting in an upright position.
Continue to sit or stand upright for 60 minutes after taking a tablet - you must confiar lie down during this time.
Do not have anything to eat or drink (other than water) for at least 30 minutes after taking a tablet. If you are taking Bonviva® tablets, you must not eat or drink anything (other than water) for 60 minutes afterwards. This is because food stops the tablet from working and makes your treatment much less effective.
Obtendo o máximo do seu tratamento
Remember to keep your regular appointments with your doctor so that your progress can be monitored. You will need to have regular blood tests during this treatment.
Good dental hygiene is important during treatment with this medicine - this means that you must brush your teeth regularly and attend routine dental check-ups. If you wear dentures, make sure these fit you properly. You should also make sure that your dentist is aware that you are having ibandronic acid, as some dental treatments may not be recommended for you while you are receiving this treatment.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some mineral supplements, iron preparations, and indigestion remedies reduce the amount of ibandronic acid which your body absorbs. This could make your treatment less effective.
Eating a well-balanced diet and taking regular exercise can help your bones stay strong. Remember to follow any exercise or dietary advice your doctor gives to you.
Chemicals from tobacco can get into your bloodstream and can affect your bones, making bone loss worse. If you smoke, you should make every effort to stop. Ask your doctor or pharmacist for advice on stopping.
Can ibandronic acid cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with ibandronic acid. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common ibandronic acid side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Indigestion, feeling sick (nausea), tummy (abdominal) pain, diarrhoea | Mantenha-se em alimentos simples - evite refeições gordurosas ou picantes |
Heartburn, chest pain, pain or difficulty when you swallow | These are signs that the tablets are irritating your throat. Speak with your doctor straightaway (and do not take any more tablets in the meantime) |
Muscle and joint pains, 'flu-like' feelings | These may occur at the beginning of treatment but should soon pass. If they continue beyond the first few days, let your doctor know |
Dor de cabeça | Beba bastante água e peça ao seu farmacêutico que recomende um analgésico adequado. Se as dores de cabeça continuarem, fale com o seu médico |
Skin rash, feeling weak | Se houver problemas, fale com seu médico |
Rare, but more serious side-effects | O que devo fazer se eu experimentar isso? |
Dor na sua coxa, quadril ou virilha | These could be signs of a thigh bone fracture. Speak with your doctor straightaway |
A loose tooth, jaw pain with swelling or numbness, a sore in the mouth that doesn't heal | These could be signs of a problem called osteonecrosis of the jaw. Speak with your doctor straightaway |
Dor de ouvido, secreção de um ouvido, infecção de ouvido | Estes podem ser sinais de um problema chamado osteonecrose do ouvido. Consulte seu médico imediatamente |
Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, fale com seu médico ou farmacêutico para mais conselhos.
How to store ibandronic acid
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá imediatamente ao departamento de emergência do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
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Perguntas frequentes
Can men take ibandronic acid for osteoporosis?
Ibandronic acid tablets for osteoporosis are only suitable for women who have gone through menopause. The article does not mention the use of ibandronic acid for osteoporosis in men.
How long will I need to keep taking ibandronic acid tablets?
The article does not specify a typical duration for ibandronic acid treatment. It states that you should keep your regular appointments with your doctor so your progress can be monitored, suggesting the treatment length will be determined by your doctor based on your condition.
Is it important to have regular blood tests while on ibandronic acid?
Yes, the article states that you will need to have regular blood tests during this treatment to monitor your progress. This helps your doctor ensure the medicine is working effectively and safely for you.
Are there any specific activities I should avoid while taking ibandronic acid?
The article advises against lying down for at least 60 minutes after taking the tablet and recommends avoiding food or drink (other than water) for at least 30-60 minutes after taking it, depending on the brand. It also suggests avoiding certain dental treatments and discussing any mineral or iron supplements or indigestion remedies with a pharmacist, as these can reduce the effectiveness of ibandronic acid.
What should I do if I accidentally chew or crush an ibandronic acid tablet?
The article explicitly states that you must swallow the tablet whole and must not chew, break, or crush it, due to the risk of irritation and damage. If this happens, it is advisable to contact your doctor or pharmacist for guidance, though the article does not specify actions for an accidental chewing or crushing.
Leitura adicional e referências
- Manufacturer's PIL, Bondronat® 50 mg film-coated tablets; Atnahs Pharma UK Ltd, The electronic Medicines Compendium. Dated May 2019.
- Manufacturer's PIL, Bonviva® 150 mg film-coated tablets; Atnahs Pharma UK Ltd, The electronic Medicines Compendium. Dated June 2021.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
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Próxima revisão prevista para: 22 de maio de 2027
23 Nov 2022 | Última versão

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