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Implante de Goserelina

Zoladex / Zoladex LA

Goserelin implants are injected under the surface of the skin on your stomach.

Each time you collect a prescription, check to make sure it looks the same as you have had before. There are two strengths of implant - Zoladex® 3.6 mg and Zoladex® LA 10.8 mg (long-acting). .

The most common side-effects are hot flushes, sweating, and reduced interest in sex.

About goserelin

Tipo de medicamento

A gonadorelin analogue (also known as an LHRH analogue)

Usado para

In women: endometriosis; uterine fibroids; breast cancer; to thin the lining of the womb (uterus) before an operation; as part of a treatment for infertility
In men
: prostate cancer

Também chamado de

Zoladex®; Zoladex® LA

Disponível como

Implant and long-acting implant

Goserelin works by acting on the pituitary gland in your brain to stop the production of some of the sex hormones which your body makes naturally. It is given for a number of different conditions. It is used to treat some cancers - câncer de próstata in men, and câncer de mama in women. It is also given to women for some problems associated with the womb, and to help treat infertilidade.

Although it is unclear exactly why prostate cancer or breast cancer develops, it is known that the sex hormones testosterone (in men) and oestrogen (in women) increase the growth of these cancers. Goserelin reduces the amount of these hormones, and this helps to stop the growth of the cancer cells.

In women, because it inhibits the production of female sex hormones, it is helpful in treating problems such as endometriose e miomas uterinos. It is also given to prepare the womb before some surgical operations. Goserelin also encourages ovulation in women, and it is for this reason it is used in infertility treatments.

Goserelin is contained in a small pellet which is implanted (like an injection) under the surface of the skin on your stomach.

Before you have goserelin

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you are given goserelin it is important that your doctor knows:

  • If you have low moods or are depressed.

  • Se você tem pressão alta.

  • Se lhe disseram que você tem um batimento cardíaco irregular.

  • Se você tem níveis elevados de açúcar no sangue (diabetes mellitus).

  • If you have any vaginal bleeding for which you do not know the cause (that is, not your normal monthly period).

  • Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

  • Se você já teve uma reação alérgica a um medicamento.

How goserelin is given

  • Before you are given the implant, ask to read the printed information leaflet from the pack. The manufacturer's leaflet will give you information about the implant and will provide a full list of the side-effects which you may experience from it. If, as a result of reading the leaflet, you have any questions, please discuss them with your doctor/nurse before you have the implant.

  • The implant will be inserted for you by a person who has been specially trained. A very small pellet will be inserted just underneath the skin on your stomach.

  • Depending on the reason for your treatment, you may require further implants at 4-weekly or 12-weekly intervals. Remember to book your next appointment in plenty of time so that you receive the implant when it is due.

  • Try to keep your regular appointments with your doctor so that your progress can be monitored. If your doctor gives you a prescription so that you can collect the goserelin implant from the pharmacy, remember to take it with you for your appointment.

Obtendo o máximo do seu tratamento

  • Goserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.

  • Information for women: if you require contraception while you are on goserelin, use a barrier method such as a condom or cap (diaphragm). Do not use oral contraceptives ('the pill'). If you are using goserelin as a fertilisation treatment, you will already have had a test to show that you are not pregnant. You should not receive goserelin if you are pregnant, or think you might be pregnant.

  • Information for men: you may notice that your symptoms become worse when you first start treatment with goserelin and your doctor will give you some tablets to take during the first few weeks to help reduce this. Your symptoms should start to improve after a couple of weeks.

Can goserelin implants cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with goserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common

goserelin side-effects (these affect more than 1 in 10 people)


O que posso fazer se passar por isso?

Hot flushes, sweating (these may continue after stopping treatment with goserelin)

Take care not to become over-heated

Erectile dysfunction, reduced interest in sex

Consulte seu médico para obter aconselhamento

Headache (in women)

Beba bastante água e peça ao seu farmacêutico para recomendar um analgésico adequado. Se as dores de cabeça continuarem, informe o seu médico

Comum

goserelin side-effects

(estes afetam menos de 1 em cada 10 pessoas)

O que posso fazer se passar por isso?

Vaginal dryness or bleeding, acne (women), changes in breast size, depressed mood, tingling in the fingers or toes, skin rash, bone pain, reactions at the site of injection, decreased bone density, changes in blood pressure, weight changes, and an increased risk of heart attack (men)

Se você estiver preocupado com algum desses, fale com seu médico

Importante: if you develop a skin rash or have any difficulties with your breathing, you should contact your doctor for advice straightaway. These are rare but possibly serious symptoms, as they may be signs of an allergic reaction.

If you notice any other problems which you think may be caused by the implant, speak with your pharmacist or doctor for advice.

How to store goserelin

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Informações importantes sobre todos os medicamentos

Se você comprar qualquer medicamento, verifique com um farmacêutico se eles são adequados para tomar com seus outros medicamentos.

Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre seus medicamentos, pergunte ao seu farmacêutico.

MHRA - Relatando reações adversas

Relate efeitos colaterais suspeitos de medicamentos, vacinas, cigarros eletrônicos, incidentes com dispositivos médicos, produtos defeituosos ou falsificados (falsos) à Agência Reguladora de Medicamentos e Produtos de Saúde para garantir o uso seguro e eficaz.

Perguntas frequentes

What is the difference between Zoladex and Zoladex LA?

The article lists 'Zoladex®' and 'Zoladex® LA' under the 'Also called' section and notes Goserelin is available as an 'Implant and long-acting implant'. This suggests Zoladex LA is simply the long-acting version of the Zoladex implant, likely referring to the 12-weekly interval instead of the usual 4-weekly one for the regular implant.

How long will I need to be on goserelin treatment?

The duration of goserelin treatment is not specified in the article, but it mentions that you may require further implants at 4-weekly or 12-weekly intervals, depending on the reason for your treatment. Your doctor will monitor your progress and advise on the total course of treatment.

Will goserelin interact with my other medications?

Yes, it's important for your doctor to know if you are taking any other medicines, including those bought without a prescription, as well as herbal and complementary medicines. This is so they can check for any potential interactions before you are given goserelin.

What should I do if I forget to get my next goserelin implant?

The article advises remembering to book your next appointment in plenty of time so that you receive the implant when it is due. If you miss an appointment or are concerned about when to get your next implant, you should contact your doctor's office for advice on rescheduling.

Can goserelin affect my mood or mental health?

Yes, goserelin can cause changes in mood. The article mentions that a depressed mood is a common side-effect, affecting fewer than 1 in 10 people. It also asks if you have low moods or are depressed as something important for your doctor to know before prescribing goserelin.

Leitura adicional e referências

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.
  • Próxima revisão prevista para: 17 Nov 2027
  • 18 de maio de 2023 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani

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