Acenocoumarol - an anticoagulant

About acenocoumarol

Acenocoumarol is an anticoagulant medicine, which means that it increases the time it takes for your blood to clot. It works by reducing the effects of vitamin K, which is a vitamin your body uses to make blood-clotting factors.

Acenocoumarol is prescribed to prevent unwanted clots from forming if you have a condition that puts you at risk of this happening, such as atrial fibrillation, or if you have had a heart valve replacement. It is also given to prevent any clots that may have already formed in the blood vessels of your legs, lungs or heart from becoming larger and causing problems. Another anticoagulant, called varfarina, is usually prescribed in preference to acenocoumarol. However, if warfarin is not suitable for you, you may be prescribed acenocoumarol instead.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking acenocoumarol it is important that your doctor knows:

• Se você está grávida, tentando ter um bebê ou amamentando.

• If you have any cuts or wounds.

• If you have a condition that increases your risk of bleeding, such as a stomach ulcer, or if you have had surgery recently, or if you have recently had a stroke.

• Se você tiver algum problema com o funcionamento do seu fígado ou com o funcionamento dos seus rins.

• Se você tem pressão alta.

• If you have been told you have an infection of your heart, called bacterial endocarditis.

• Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

• Se você já teve uma reação alérgica a um medicamento.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack of tablets and any additional information you have been given by your doctor. These will give you more information about acenocoumarol and will provide you with a full list of the side-effects which you may experience from taking it.

• Take acenocoumarol once a day, exactly as you have been advised by your doctor or anticoagulant clinic. You should aim to take acenocoumarol at the same time each day. This will help keep the levels of the medicine in your blood steady and will also help you to avoid missing any doses. Your doctor will tell you how many tablets to take for each dose. Swallow the tablet(s) whole with a drink of water.

• If you forget to take a dose at your usual time, take it as soon as you remember if it is still the same day. If you do not remember until the following day, do not take the missed dose but do remember to take the dose that is due on that day. Remember to let your doctor know about any missed doses when you next have your blood test.

• Continue to take acenocoumarol tablets regularly until your doctor tells you to stop. A course of treatment typically lasts from six weeks to three months, although some people may be advised to continue taking the tablets long-term.

• You will be given a yellow 'Oral Anticoagulant Therapy' booklet; please read this carefully as it gives you important information such as when you should contact a doctor for advice. You will also be given an 'Anticoagulant Alert Card' which you should carry with you at all times. In case of an emergency, a doctor will need to know that you are taking acenocoumarol.

• You will need to have regular blood tests to check on how quickly your blood clots. Blood tests may be needed quite often at first but should reduce in frequency quite quickly. The extent to which acenocoumarol is working is measured by the International Normalised Ratio (INR), which is a measure of the ability of your blood to prevent clotting. The amount of acenocoumarol that you need to take will depend upon the result of these blood tests and this is why your dose may change from time to time. The aim is to get the dose of acenocoumarol just right so your blood does not clot as easily as normal but not so much as to cause bleeding problems.

• Changing your diet suddenly can affect your INR, especially if you begin to eat more vegetables and salad than before. You should not begin a weight-reducing diet without discussing it with your doctor first. A major change in diet will mean that you need closer monitoring as your dose may need to be adjusted.

• Only drink alcohol in small amounts, as this can affect the levels of the medicine in your body. Limit the amount of alcohol that you drink to a maximum of one or two units in any day and never binge drink.

• Drinking cranberry juice can interfere with acenocoumarol and affect your INR, so it is best if you avoid cranberry juice and other cranberry products altogether.

• If you buy any medicines, check with a pharmacist that they are safe to take with acenocoumarol. For example, you should not take some painkillers (such as aspirin and other anti-inflammatory painkillers) and some vitamin and herbal preparations. If you need to take a painkiller, you may take paracetamol but you should let your doctor know if you need to take it regularly.

• Because acenocoumarol is used to prevent blood clots from forming, you should try to avoid activities that could cause you to cut or bruise yourself, such as contact sports. Let your doctor know if you have any falls or injuries.

• You should avoid getting pregnant while you are taking acenocoumarol as it may cause harm to an unborn baby. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

• If you are due to have any injections, or any medical or dental treatment, please tell the person carrying out the treatment that you are taking an anticoagulant and show them your treatment booklet. It is important that they know you may take longer to stop bleeding. If you are due to have surgery, you may be advised to stop taking acenocoumarol for a few days and be given injections instead.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the side-effects associated with acenocoumarol - the most common ones are bleeding and bruising. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, fale com seu médico ou farmacêutico para mais orientações.

• Mantenha todos os medicamentos fora do alcance e da vista das crianças.

• Store in a cool, dry place, away from direct heat and light.