Triamterene - a 'water' tablet or diuretic
Dyrenium
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSLast updated 5 de maio de 2025
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Nota do autor clínico Michael Stewart 15/06/2022: Triamterene capsules were discontinued in the UK in November 2021. Currently triamterene is only available in the UK in combination with another diuretic medicine called clortalidona. At the time of review there are no branded or generic products solely containing triamterene available in the UK. Products may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Triamterene is a 'water' tablet (diuretic) - it will make you want to go to the toilet more often to pass urine.
It may cause your urine to look slightly blue in some lights - this is harmless.
Qualquer efeito colateral geralmente é leve.
At a glance
Triamterene is a potassium-sparing diuretic used to treat water retention (oedema).
It makes you pass more urine, reducing fluid build-up in your body.
Take triamterene exactly as your doctor tells you, usually no later than mid-afternoon.
Your doctor will regularly check your blood salt levels.
Avoid foods with high potassium content, like 'salt substitutes'.
Common side effects include feeling sick, vomiting, or diarrhoea.
Tell your doctor if you have kidney or liver problems or are pregnant.
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About triamterene
Tipo de medicamento | A potassium-sparing diuretic |
Usado para | Water retention (oedema) |
Também chamado de | Dyrenium® (USA); |
Disponível como | Triamterene 50 mg/ chlortalidone 50 mg tablets |
Triamterene belongs to the group of medicines known as potassium-sparing diuretics. A diuretic is a medicine which increases the amount of urine that you pass out from your kidneys. They are often referred to as 'water' tablets. Triamterene is called a potassium-sparing diuretic because, unlike some other diuretics, it does not cause your body to lose potassium. It is used to treat water retention (oedema), and it is also given alongside other diuretics to reduce the amount of potassium they cause your body to lose.
Oedema occurs when fluid leaks out of your blood vessels, causing swelling in the tissues of your lungs, feet or ankles. This makes you feel breathless and your legs feel puffy. It is commonly caused by heart failure or liver disease. Triamterene prevents the build-up of this fluid by increasing the amount of urine your kidneys produce.
In the UK, triamterene is only available in combination with another diuretic medicine called clortalidona. This combination can help cut down on the number of tablets you need to take each day.
Before taking triamterene
Voltar ao conteúdoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking triamterene it is important that your doctor knows:
Se você está grávida ou amamentando.
If you have problems with the way your kidneys work, or any difficulty passing urine.
Se você tiver algum problema com o funcionamento do seu fígado.
Se você tem diabetes.
If you have attacks of gout.
If you have been told by a doctor that you have high levels of potassium in your blood.
If you have a problem with your adrenal glands, called doença de Addison.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
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How to take triamterene
Voltar ao conteúdoBefore you start the treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about triamterene and will also provide you with a full list of side-effects which you could experience from taking it.
Take triamterene exactly as your doctor tells you to. It is usual, to begin with, to take 3-5 capsules a day divided into two doses, one dose with your breakfast and the other at lunchtime. After the first week or so, your doctor is likely to ask you to take the capsules on alternate days only. The directions for taking your doses will be printed on the label of the pack to remind you about what the doctor said to you.
Diuretics are best taken no later than mid-afternoon. This is because you will find you may need to go to the toilet a couple of times after taking it and this will disturb your sleep if you take it too late in the day.
Swallow the capsules with a drink of water. You can take triamterene either with or without food.
If you forget to take a dose of triamterene, take it when you remember if it is only a few hours late. If it is after mid-afternoon, leave out the forgotten dose completely and take your next dose when it is due. Do not take two doses at the same time to make up for a missed dose.
Obtendo o máximo do seu tratamento
Voltar ao conteúdoTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The balance of salts in your blood may be upset by triamterene so your doctor may want you to have a blood test from time to time to check for this.
Diuretics help you to lose water, so you can breathe and move more easily. If, however, you lose too much fluid, you may become lacking in fluid in the body (dehydrated). This will make you feel thirsty and make your skin look and feel dry. Let your doctor know if this happens, as your dose may need to be adjusted.
Because triamterene is a potassium-sparing diuretic, you should try to avoid things with a high potassium content, such as 'salt substitutes'. This is so the level of potassium in your body does not become too high.
Treatment with diuretics is usually long-term, so continue to take triamterene unless your doctor advises you otherwise.
If you buy any medicines 'over the counter', please check with a pharmacist that they are suitable for you to take alongside your prescribed medicines.
Triamterene can cause your urine to look slightly blue in some lights - this is harmless and nothing to be concerned about.
Se você também estiver tomando hidroclorotiazida em combinação com este medicamento
Estudos sugerem que tomar doses mais altas de hidroclorotiazida por longos períodos de tempo pode aumentar o risco de certos tipos de câncer de pele.
Informe o seu médico se você já foi tratado para câncer de pele antes.
Informe seu médico sobre qualquer nova pinta ou alteração em pintas existentes, ou marcas preocupantes na sua pele.
Use protetor solar sob luz solar intensa. Não use camas de bronzeamento.
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Can triamterene cause problems?
Voltar ao conteúdoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the common ones associated with triamterene. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common triamterene side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Sentindo-se mal (náusea) ou vomitando (vômito) | Stick to simple foods - avoid fatty or spicy meals. Try taking the capsules after a meal or a snack |
Diarreia | Beba bastante água para repor os líquidos perdidos |
Alterações nos resultados de alguns exames de sangue | Your doctor will check for this from time to time |
Se você sentir quaisquer outros sintomas que acha que podem ser devido às cápsulas, por favor, fale com seu médico ou farmacêutico para mais orientações.
How to store triamterene
Voltar ao conteúdoMantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Voltar ao conteúdoInformações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você estiver prestes a fazer uma operação ou qualquer tratamento dentário, por favor, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is the main difference between triamterene and other diuretics?
Triamterene is known as a 'potassium-sparing' diuretic. This means that, unlike some other diuretics which can cause your body to lose potassium, triamterene does not have this effect. It can also be given with other diuretics to help prevent them from causing potassium loss.
Why do I need to be careful about foods high in potassium while taking triamterene?
Because triamterene is a potassium-sparing diuretic, it helps your body retain potassium. To prevent your potassium levels from becoming too high, you should try to avoid consuming foods or products with a high potassium content, such as 'salt substitutes'.
What should I do if I become very thirsty or my skin feels dry while taking this medication?
These symptoms could indicate that you are losing too much fluid and becoming dehydrated. You should let your doctor know if this happens, as your dose of triamterene may need to be adjusted.
How often will I need to see my doctor while taking triamterene?
You should try to keep your regular appointments with your doctor so they can monitor your progress. Triamterene can affect the balance of salts in your blood, so your doctor may ask you to have blood tests periodically to check these levels.
If I notice my urine has a blue tint, should I be concerned?
No, if your urine looks slightly blue in some lights while taking triamterene, this is harmless and there is no need to be concerned.
What if I miss a dose of triamterene?
If you remember within a few hours of the missed dose, you should take it. However, if it's already after mid-afternoon, you should skip that dose completely and take your next dose at its scheduled time. Never take a double dose to make up for a forgotten one.
Can I take other medicines, including over-the-counter remedies, with triamterene?
Before taking any other medicines, including those you can buy without a prescription, or any herbal and complementary medicines, you should check with a pharmacist to ensure they are suitable to take alongside your prescribed triamterene.
Leitura adicional e referências
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão prevista para: 5 de maio de 2028
5 de maio de 2025 | Última versão

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