transforming growth factor beta 3
Última atualização 18 de ago de 2020
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A TGFB3 gene provides instructions for producing a protein called transforming growth factor beta-3 (TGFβ-3). This protein is found throughout the body and is required for development before birth and throughout life. To carry out its functions, TGFβ-3 attaches (binds) to receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell, controlling various cellular activities. As part of a signaling pathway, called the TGF-β pathway, the TGFβ-3 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis). Because the TGFβ-3 protein keeps cells from growing and dividing too rapidly or in an uncontrolled way, it can suppress the formation of tumours.
Normal function
A TGFB3 gene provides instructions for producing a protein called transforming growth factor beta-3 (TGFβ-3). This protein is found throughout the body and is required for development before birth and throughout life. To carry out its functions, TGFβ-3 attaches (binds) to receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell, controlling various cellular activities. As part of a signaling pathway, called the TGF-β pathway, the TGFβ-3 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis). Because the TGFβ-3 protein keeps cells from growing and dividing too rapidly or in an uncontrolled way, it can suppress the formation of tumours.
The TGFβ-3 protein is especially abundant in tissues that develop into the muscles used for movement (skeletal muscles), and plays a key role in their development. The protein is also involved in the formation of blood vessels, regulation of bone growth, wound healing, and immune system function.
Conditions referring to this gene or chromosome
Other names
RNHF
TGF beta 3
TGF-beta3
Related patient information and medicines
Patient information leaflet
Talasemia
Thalassaemia is an inherited condition affecting the blood. Thalassaemia is an inherited (genetic) condition affecting the blood. Haemoglobin is made out of different parts. The main parts are called alpha chains and beta chains which are put together to make the haemoglobin molecule. In thalassaemia, part of the haemoglobin is faulty - usually.
Patient information leaflet
Acromegalia
Acromegalia is a rare, progressive condition in which you make too much growth hormone. This causes a range of symptoms that develop gradually, often over several years. The most noticeable symptoms are that your hands and feet become larger and features of your face may become more prominent. The cause is usually a small non-cancerous growth.
Patient information leaflet
Genu valgo
Knock knees describes an unusual angle of the lower legs. Most commonly it is a normal shape as children's legs develop, but occasionally in children or adults it can cause problems or have an underlying cause. Most children who have knock knees grow out of the condition. What are knock knees. The medical term for knock knees is 'genu valgum' -.
Patient information leaflet
Câncer de boca
What does mouth cancer look like. The most common mouth cancer symptoms are a sore or ulcer in the mouth that does not heal and pain in the mouth that does not go away. Other treatments Newer treatments are being used in research for the treatment of mouth cancer: Targeted therapy is a type of chemotherapy that only affects or targets cancer.
Patient information leaflet
Deficiência de vitamina A
Vitamin ... Foods that contain vitamin A include liver, milk, eggs and fish-liver oils. Another substance called beta carotene (which is found in green leafy and orange/yellow vegetables and fruits) can also be converted by your body to vitamin A. Mild forms of vitamin A deficiency can usually be treated without any long-term problems. Vitamin A.
Patient information leaflet
Posso tomar Ciprofloxacino e Doxiciclina juntos?
There is also a theoretical possibility that they could interfere with each other's ability to ki... Why this happens Both are antibiotics but they work in different ways. Doxycycline stops bacteria from growing (bacteriostatic), while ciprofloxacina actively kills them (bactericidal). In some cases, stopping the growth can make the 'killing'.
Leitura adicional e referências
- transforming growth factor beta 3; MedlinePlus, National Library of Medicine.
- Bertoli-Avella AM, Gillis E, Morisaki H, Verhagen JMA, de Graaf BM, van de Beek G, Gallo E, Kruithof BPT, Venselaar H, Myers LA, Laga S, Doyle AJ, Oswald G, van Cappellen GWA, Yamanaka I, van der Helm RM, Beverloo B, de Klein A, Pardo L, Lammens M, Evers C, Devriendt K, Dumoulein M, Timmermans J, Bruggenwirth HT, Verheijen F, Rodrigus I, Baynam G, Kempers M, Saenen J, Van Craenenbroeck EM, Minatoya K, Matsukawa R, Tsukube T, Kubo N, Hofstra R, Goumans MJ, Bekkers JA, Roos-Hesselink JW, van de Laar IMBH, Dietz HC, Van Laer L, Morisaki T, Wessels MW, Loeys BL. Mutations in a TGF-beta ligand, TGFB3, cause syndromic aortic aneurysms and dissections. J Am Coll Cardiol. 2015 Apr 7;65(13):1324-1336. doi: 10.1016/j.jacc.2015.01.040.
- Matyas G, Naef P, Tollens M, Oexle K. De novo mutation of the latency-associated peptide domain of TGFB3 in a patient with overgrowth and Loeys-Dietz syndrome features. Am J Med Genet A. 2014 Aug;164A(8):2141-3. doi: 10.1002/ajmg.a.36593. Epub 2014 May 5. No abstract available.
- Rienhoff HY Jr, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M. A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A. 2013 Aug;161A(8):2040-6. doi: 10.1002/ajmg.a.36056. Epub 2013 Jul 3.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.