Catecholaminergic polymorphic ventricular tachycardia
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Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition characterised by an abnormal heart rhythm (arrhythmia). As the heart rate increases in response to physical activity or emotional stress, it can trigger an abnormally fast heartbeat called ventricular tachycardia. Episodes of ventricular tachycardia can cause light-headedness, dizziness, and fainting (syncope). In people with CPVT, these episodes typically begin in childhood.
Descrição
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition characterised by an abnormal heart rhythm (arrhythmia). As the heart rate increases in response to physical activity or emotional stress, it can trigger an abnormally fast heartbeat called ventricular tachycardia. Episodes of ventricular tachycardia can cause light-headedness, dizziness, and fainting (syncope). In people with CPVT, these episodes typically begin in childhood.
If CPVT is not recognized and treated, an episode of ventricular tachycardia may cause the heart to stop beating (cardiac arrest), leading to sudden death. Researchers suspect that CPVT may be a significant cause of sudden death in children and young adults without recognized heart abnormalities.
Padrões de herança
The source lists the following possible inheritance patterns: Autosomal dominant; Autosomal recessive. More than one pattern can apply in different cases.
Related genes
Other names
Bidirectional tachycardia induced by catecholamines
Catecholamine-induced polymorphic ventricular tachycardia
CPVT
Familial polymorphic ventricular tachycardia
FPVT
Related patient information and medicines
Patient information leaflet
Ritmos cardíacos anormais
An arrhythmia is an abnormal rate and/or rhythm of the heartbeat due to some problem with the electrical conducting system of the heart. What is an arrhythmia. An arrhythmia is an abnormal rate and/or rhythm of the heartbeat. Atr... The atria contract at about 300 bpm but the ventricles are unable to beat that quickly and so beat at between 75 and.
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Síndrome de Wolff-Parkinson-White
Síndrome de Wolff-Parkinson-White is not common but can cause a fast coração rate or other ritmo cardíaco abnormalities from time to time. Treatment can be given for the fast heart rate and also to prevent any further episodes. In síndrome de Wolff-Parkinson-White (WPW) there is an extra connection (an accessory pathway) between the atria and ventricles..
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Palpitações cardíacas
Palpitações cardíacas são the sensation of your heart beating and are common. Most cases are harmless. They usually only last for a short time and can be accompanied by other symptoms such as breathlessness, dizziness, chest tightness and a feeling of anxiety. Palpitations that are severe or don't settle quickly may need urgent medical attention. The.
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Doença cardíaca
The heart is a muscle pump located in the chest, which pumps sangue around the body. It keeps pumping from a few weeks after conception until we die. There are a number of different conditions that can affect how the heart works. What is heart disease. There are many different conditions which can affect the heart, including those which affect the.
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Doença de Bornholm
Bornholm disease is an illness which causes flu-like symptoms, together with pain in the chest or tummy (abdomen). It usually lasts for only a few days. Complications rarely occur. Most people make a full recovery within days or weeks. However, the following complications have been seen in a few cases: Heart problems - inflamação around the.
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Betabloqueadores
Betabloqueadores são para resfriado that are used to treat a variety of conditions. Their full correct name is beta-adrenoceptor blocking medicines (or beta-adrenergic blocking agents), but they are commonly just called beta-blockers. How do beta-blockers work. Lower your blood pressure if you have high blood pressure. Treat postural tachycardia syndrome.
Leitura adicional e referências
- Catecholaminergic polymorphic ventricular tachycardia; MedlinePlus, National Library of Medicine.
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- Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC. Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol. 2016 Aug;9(8):10.1161/CIRCEP.116.004161 e004161. doi: 10.1161/CIRCEP.116.004161.
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- Napolitano C, Mazzanti A, Bloise R, Priori SG. Catecholaminergic Polymorphic Ventricular Tachycardia. 2004 Oct 14 [updated 2022 Jun 23]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1289/
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- Pflaumer A, Davis AM. Guidelines for the diagnosis and management of Catecholaminergic Polymorphic Ventricular Tachycardia. Heart Lung Circ. 2012 Feb;21(2):96-100. doi: 10.1016/j.hlc.2011.10.008. Epub 2011 Nov 25.
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- Roston TM, Cunningham TC, Sanatani S. Advances in the diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia. Cardiol Young. 2017 Jan;27(S1):S49-S56. doi: 10.1017/S1047951116002237.
- Roston TM, Van Petegem F, Sanatani S. Catecholaminergic polymorphic ventricular tachycardia: a model for genotype-specific therapy. Curr Opin Cardiol. 2017 Jan;32(1):78-85. doi: 10.1097/HCO.0000000000000360.
- Roux-Buisson N, Cacheux M, Fourest-Lieuvin A, Fauconnier J, Brocard J, Denjoy I, Durand P, Guicheney P, Kyndt F, Leenhardt A, Le Marec H, Lucet V, Mabo P, Probst V, Monnier N, Ray PF, Santoni E, Tremeaux P, Lacampagne A, Faure J, Lunardi J, Marty I. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum Mol Genet. 2012 Jun 15;21(12):2759-67. doi: 10.1093/hmg/dds104. Epub 2012 Mar 14.
- van der Werf C, Wilde AA. Catecholaminergic polymorphic ventricular tachycardia: from bench to bedside. Heart. 2013 Apr;99(7):497-504. doi: 10.1136/heartjnl-2012-302033. Epub 2013 Feb 6. No abstract available.
- van der Werf C, Zwinderman AH, Wilde AA. Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments. Europace. 2012 Feb;14(2):175-83. doi: 10.1093/europace/eur277. Epub 2011 Sep 4.
- Wall JJ, Iyer RV. Catecholaminergic Polymorphic Ventricular Tachycardia. Pediatr Emerg Care. 2017 Jun;33(6):427-431. doi: 10.1097/PEC.0000000000001156.
- Wleklinski MJ, Kannankeril PJ, Knollmann BC. Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2020 Jul;598(14):2817-2834. doi: 10.1113/JP276757. Epub 2020 Apr 27.
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