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Can I take Ciprofloxacin and Doxycycline together?

Guia de interação medicamentosa

Taking ciprofloxacin and doxycycline together may slightly increase the risk of side effects, such as skin sensitivity to sunlight or digestive upset. There is also a theoretical possibility that they could interfere with each other's ability to kill bacteria, though they are sometimes prescribed together for specific complex infections.

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Por que isso acontece

Both are antibiotics but they work in different ways. Doxycycline stops bacteria from growing (bacteriostatic), while ciprofloxacin actively kills them (bactericidal). In some cases, stopping the growth can make the 'killing' antibiotic less effective, though this is rarely a problem in clinical practice. Both drugs also share a side effect of making your skin more sensitive to UV light.

You can take these together if your doctor has specifically prescribed both. Ensure you wear high-factor sunscreen and protective clothing, as both drugs increase your risk of severe sunburn. If you experience severe diarrhoea or stomach pain, contact your doctor immediately. Take them at least 2 hours apart from any antacids, dairy, or iron supplements, as these can stop both medicines from being absorbed properly.

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Tendonitis or tendon rupture

Stop taking this medicine and seek immediate medical help if you experience pain, swelling, or inflammation in any tendon (such as the ankle or wrist).

Ciprofloxacin increases the risk of tendon rupture, even after the course is finished.

Sunlight exposure (Photosensitivity)

These medicine make your skin much more sensitive to sunlight. Avoid bright sunlight and do not use sunbeds; use a high-factor sun cream even on cloudy days to prevent severe skin reactions.

Dairy and Antacid interaction

Não tome these medicines at the same time as dairy products (like milk or yoghurt) or indigestion remedies (antacids). These can stop the medicine from being absorbed properly. Leave a gap of at least 2 hours between them.

Pregnancy and childhood

Doxycycline must not be taken during pregnancy or by children under 12 years old, as it can permanently discolour developing teeth and affect the growth of a baby's bones.

Caffeine (coffee, tea, cola, energy drinks)

Ciprofloxacin can stop your body from breaking down caffeine as quickly as usual. This can lead to a build-up of caffeine in your system, making you feel shaky, restless, or causing a racing heartbeat and insomnia.

It is best to limit your caffeine intake while taking this medicine.

Álcool

While there is no direct interaction between ciprofloxacin and alcohol, both can make you feel dizzy or lightheaded. It is generally advised to avoid alcohol until you know how the medicine affects you and until you have recovered from your infection.

Multivitamins and minerals (Iron, Magnesium, Zinc, Aluminium)

Supplements or fortified foods containing these minerals can stop these antibiotics from working. Take your medicine at least 2 hours before or 4-6 hours after any supplements or antacids.

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Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.

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Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • 24 Jan 2026 | Publicado originalmente
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