Tipranavir para HIV

About tipranavir

Tipranavir is an antiretroviral medicine. It is prescribed for infecção pelo vírus da imunodeficiência humana (HIV). It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Tipranavir slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the production of a protein that the virus needs to copy (replicate) itself.

Tipranavir will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as protease inhibitors (PIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine.

It is vital to take your antiretroviral medicines exactly as prescribed in order to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking tipranavir it is important that your doctor knows:

• Se você está grávida, tentando ter um bebê ou amamentando.

• Se você tem diabetes (diabetes mellitus).

• Se você tem inflamação no fígado (chamada hepatite) ou qualquer outro problema hepático.

• If you have been told you are at risk of bleeding, such as if you have recently had surgery or an accident.

• Se você tem hemofilia ou porfiria, que são ambos distúrbios hereditários raros do sangue.

• Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

• Se você já teve uma reação alérgica a um medicamento.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about tipranavir, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take tipranavir exactly as your doctor tells you to. The adult dose is two capsules twice daily, at the same time as a medicine called ritonavir - take the doses 12 hours apart. Ritonavir is prescribed to boost the action of tipranavir, so it is important that you take these medicines together. If your child has been given liquid medicine to take, your doctor will advise you about how much you should give for each dose. The directions for taking the medicine will also be printed on the label of the pack to remind you about what the doctor said to you.

• Tipranavir should be taken with food, so after a meal or with a snack. Swallow the capsules whole with a drink of water. Do not crush or open them.

• Try to take tipranavir at the same times of day each day (in the morning and evening), as this will help you to remember to take it regularly.

• If you forget to take a dose on time, take it as soon as you remember providing it is within five hours of the time you should have taken it. If it is more than five hours since you should have taken it, leave out the missed dose but remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.

Instructions for using the dosing syringe for Aptivus® Oral Solution

1. Remove the bottle cap.

2. Make sure the plunger of the syringe is pushed in fully, then insert the syringe into the adapter.

3. Vire o frasco (com a seringa conectada a ele) de cabeça para baixo.

4. Gently pull out the plunger of the syringe so that the medicine fills the syringe to the mark which corresponds to your child's dose.

5. Vire a garrafa para a posição correta novamente e remova a seringa da garrafa.

6. Put the tip of the syringe into your child's mouth, and gently push the plunger so that the medicine is released.

7. Replace the bottle cap.

• Keep your regular appointments with your doctor so that your progress can be monitored. You will need to have regular blood tests, particularly when you first start taking tipranavir.

• It is important that you continue to take tipranavir and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop any infection soon after you start this treatment, let your doctor know. As a result of taking tipranavir, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Siga cuidadosamente qualquer conselho que seu médico lhe der sobre fazer mudanças no estilo de vida para reduzir qualquer risco de danos ao seu coração e vasos sanguíneos. Isso pode incluir parar de fumar, comer de forma saudável e fazer exercícios regularmente.

• Algumas pessoas que tomam medicamentos antirretrovirais desenvolvem alterações na forma como a gordura corporal é distribuída no corpo. Isso pode resultar em mudanças na imagem corporal. Seu médico discutirá a possibilidade disso com você.

• Embora o tratamento com medicamentos antirretrovirais possa reduzir o risco de você transmitir o HIV a outras pessoas através do contato sexual, ele não o elimina. É importante que você use preservativos.

• Não é incomum que pessoas com HIV se sintam desanimadas ou até deprimidas, especialmente logo após o diagnóstico ter sido feito e o tratamento ter começado. Se você tiver qualquer sentimento de depressão, ou pensamentos angustiantes sobre se machucar, você deve falar com seu médico imediatamente.

• Algumas pessoas que tomaram medicamentos antirretrovirais (particularmente por um longo período) desenvolveram uma condição chamada osteonecrose. Esta é uma doença óssea em que o tecido ósseo morre devido à redução do suprimento de sangue. Isso leva a dores nas articulações e rigidez, e pode causar dificuldades de movimento. Se você notar algum desses sintomas, fale com seu médico.

• If you buy any medicines or herbal remedies, check with a pharmacist that they are suitable to take with tipranavir and your other medicines. This is because some remedies interfere with tipranavir and stop it from working properly. In particular, do not take indigestion remedies during the two hours before or during the two hours after you take your doses. Also, do not take St John's wort.

• Se você tem diabetes, pode precisar verificar seus níveis de açúcar no sangue (glicose) com mais frequência, pois este medicamento pode afetar os níveis de açúcar no seu sangue. Seu médico irá orientá-lo sobre isso.

• Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.

• Treatment for HIV is usually lifelong. Continue to take tipranavir regularly for as long as your doctor tells you to, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with tipranavir. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, fale com seu médico ou farmacêutico para mais conselhos.

• Mantenha todos os medicamentos fora do alcance e da vista das crianças.

• Store unopened packs of Aptivus® Capsules in a refrigerator. Once opened, they can be stored in a cool, dry place, away from direct heat and light for up to 60 days.

• Store Aptivus® Oral Solution at room temperature - do confiar refrigerate. Once a bottle has been opened it will keep for 60 days - after this time, make sure you have a fresh supply. If crystals start to form on the top of the medicine, ask your doctor or pharmacist to replace the bottle. You should continue to take the medicine until the fresh supply is available.