About sorafenib

In cancer, certain cells in the body grow and multiply in a way that is 'out of control'. Medicines like sorafenib slow down the way cancer cells grow and spread. Sorafenib belongs to a group of anti-cancer medicines known as kinase inhibitors. These work by blocking chemical messengers (called kinases) which send signals to cells to grow. In addition to this action, sorafenib also has a second way of working - it prevents the cancer from developing the blood vessels which it needs in order for its cells to grow. Together, these actions slow down the spread of cancer cells.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sorafenib it is important that your doctor knows:

• Se você estiver com uma infecção ou se sentir especialmente mal.

• Se você tem uma condição cardíaca ou um ritmo cardíaco irregular.

• If you have raised blood sugar levels (diabetes).

• Se você está grávida ou amamentando.

• Se você estiver tomando ou usando qualquer outro medicamento. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

• Se você já teve uma reação alérgica a um medicamento.

• Before you start the treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet from inside the pack of tablets. These will give you more information about sorafenib and will provide a full list of the side-effects which you may experience from taking it.

• Sorafenib will be prescribed for you by a specialist doctor who is experienced in treating your condition. It is important that you take the tablets exactly as you are told to. It is usual to be prescribed two tablets of 200 mg to take twice daily. The directions for taking the tablets will be printed on the label of the pack to remind you what your doctor has told you to do, but if you have any concerns or questions, you should contact your doctor or hospital clinic for further advice.

• Swallow the tablets with a drink of water. You can take the tablets either when your stomach is empty (which means taking your doses an hour before a meal or waiting until two hours afterwards), or after a low-fat meal. Do not take your doses after meals which contain high amounts of fat. High-fat foods can interfere with the way your body absorbs sorafenib and this could make your treatment less effective.

• If you forget to take a dose, take it as soon as you remember unless your next dose is due. If it is nearly time for your next dose then take the dose which is due but leave out the forgotten dose. Do not take two doses together to make up for a missed dose.
  

• Você deve tentar manter seus compromissos regulares com seu médico ou hospital. Isso é para que seu médico possa acompanhar seu progresso. Você precisará fazer exames de rotina durante o tratamento.

• Treatment with sorafenib can cause low blood sugar levels. If you are also taking medication for diabetes your dosage may need changing. Discuss this with your doctor.

• If you buy or take any other medicines, check with a pharmacist that they are suitable to take alongside sorafenib. You should not take any preparations which contain St John's wort (a herbal remedy used for low moods), as it can reduce the effectiveness of sorafenib.

• Se você estiver passando por uma cirurgia ou tratamento dentário, sempre informe a pessoa que está realizando o procedimento quais medicamentos você está tomando.

• It is important that you do not get pregnant while you are taking sorafenib. If this could be a possibility for you, make sure you discuss with your doctor which types of contraception are suitable for you and your partner.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with sorafenib. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects may improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se você sentir quaisquer outros sintomas que acha que podem ser causados pelos comprimidos, fale com seu médico ou farmacêutico.

• Mantenha todos os medicamentos fora do alcance e da vista das crianças.

• Armazene em local fresco e seco, longe de calor e luz diretos.

• Please return any unused or unwanted tablets to your clinic or pharmacy to destroy.