Fenitoína para epilepsia
Epanutin
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSLast updated 2 Jan 2024
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Try to keep your regular doctor's appointments. Your doctor may need to test your blood to decide the correct dose for you.
You need to take phenytoin regularly. Do not stop taking it unless your doctor tells you to.
Different formulations and brands of phenytoin can act in a slightly different way in your body. Each time you collect a prescription, check to make sure your supply looks the same as you have had before. If not, please ask your pharmacist to check your prescription for you.
At a glance
Phenytoin is an antiepileptic medicine for conditions like epilepsy and trigeminal neuralgia.
It helps prevent seizures by stabilising the brain's electrical activity.
Take phenytoin exactly as prescribed, usually with food, and at the same times each day.
Do not stop taking it suddenly, as this can cause problems.
Report mood changes or thoughts of self-harm to your doctor immediately.
If you get a severe rash, fever, sore throat, or unusual bruising, contact your doctor straight away.
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About phenytoin
Tipo de medicamento | Um medicamento antiepiléptico |
Usado para | Epilepsy in children and adults; trigeminal neuralgia |
Também chamado de | Phenytoin sodium, Epanutin® |
Disponível como | Tablets, capsules, chewable tablets and oral liquid medicine |
If you have epilepsy, it means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different functions of your body, so the symptoms that occur during a seizure will depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these. The seizures can be prevented in most people by suitable antiepileptic medication. Phenytoin is a commonly used medicine. It works by stabilising the electrical activity of your brain, which prevents the seizures from occurring.
Phenytoin is also prescribed as a treatment for severe burning or stabbing pains in the face, a nerve pain called trigeminal neuralgia. This is because it can modify some types of pain. If you have been given phenytoin for this reason, ask your doctor if you have questions about your treatment.
Before taking phenytoin
Voltar ao conteúdoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if you are their carer) start taking phenytoin it is important that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
Se você tiver algum problema com o funcionamento do seu fígado.
Se você tem um distúrbio sanguíneo hereditário raro chamado porfiria.
Se você já teve uma reação alérgica a um medicamento.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
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How to take phenytoin
Voltar ao conteúdoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about phenytoin and will provide you with a full list of the side-effects which you may experience from taking it.
Take phenytoin exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose.
It is important you try to take your doses at the same times each day. Having a routine will help you to remember to take your doses regularly. Although phenytoin can be taken before a meal, it is better taken during or straight after a meal.
If you are taking phenytoin chewable tablets (Epanutin® Infatabs), you can chew the tablet to help you swallow or you can swallow the tablet in the usual way with a drink of water.
If you are taking phenytoin oral liquid medicine (Epanutin® suspension), make sure that you shake the bottle well before you measure out your dose.
If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose, take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Obtendo o máximo do seu tratamento
Voltar ao conteúdoQuando você inicia um novo tratamento para epilepsia, pode haver uma mudança no número ou tipo de convulsões que você experimenta. Seu médico irá aconselhá-lo sobre isso.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests from time to time.
Enquanto você está sendo tratado para epilepsia, há um pequeno risco de que você possa desenvolver mudanças de humor, pensamentos angustiantes e sentimentos sobre suicídio. Se isso acontecer, você deve informar seu médico imediatamente.
Pessoas com epilepsia devem parar de dirigir inicialmente. Seu médico irá aconselhá-lo sobre quando poderá ser possível começar a dirigir novamente. Isso geralmente será após um ano sem convulsões.
Different formulations and brands of phenytoin can act in a slightly different way in your body. Because of this, it is important that you continue to take phenytoin from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
If you drink alcohol, ask your doctor for advice. Your doctor may advise you not to drink alcohol while you are on this medicine because it can alter the amount of phenytoin in your body.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with your antiepileptic medication. Some indigestion remedies can interfere with the amount of phenytoin in your body.
Many antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. Phenytoin can make oral contraceptives less effective. Your doctor will advise you on other types of contraception such as an intra-uterine device (IUD) and barrier methods. You should use effective contraception throughout treatment with phenytoin and for one month after stopping. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist antes you become pregnant.
You need to take phenytoin regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.
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Can phenytoin cause problems?
Voltar ao conteúdoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with phenytoin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common phenytoin side-effects | O que posso fazer se passar por isso? |
Sentindo-se mal (náusea) ou vomitando (vômito) | Mantenha refeições simples - evite alimentos ricos ou picantes |
Constipação | Coma uma dieta equilibrada e beba bastante água todos os dias |
Feeling dizzy or sleepy; eyesight problems such as double vision | Não dirija e não use ferramentas ou máquinas enquanto estiver afetado |
Dor de cabeça | Beba bastante água e peça ao seu farmacêutico para recomendar um analgésico adequado. Se as dores de cabeça continuarem, informe o seu médico |
Erupção | Let your doctor know about this as soon as possible, even if it is mild |
Difficulty sleeping, numb or tingling feelings, lack of appetite, sore or swollen gums, facial changes, acne, increased hair growth, slurred speech, lack of concentration, and feeling confused, nervous, unsteady or shaky | Se algum destes se tornar problemático, informe o seu médico |
Importante: your doctor will discuss with you the possibility that phenytoin can cause blood and skin disorders. Although these occur less commonly than the side-effects listed above, it is important that you contact your doctor straightaway if you experience any of the following symptoms:
Febre alta, dor de garganta ou glândulas inchadas.
Uma erupção cutânea grave.
Úlceras na boca.
Hematomas ou sangramento inexplicáveis.
If you experience any other symptoms which you think may be due to phenytoin, speak with your doctor or pharmacist for further advice.
How to store phenytoin
Voltar ao conteúdoMantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Voltar ao conteúdoInformações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
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Perguntas frequentes
Can I take other medicines, including over-the-counter ones, while on phenytoin?
It is important to tell your doctor about all medicines you are taking, including those available without a prescription, as well as herbal and complementary medicines. Some medicines you buy, like certain indigestion remedies, can affect how much phenytoin is in your body. Always check with a pharmacist to ensure any new medicines are suitable to take with your antiepileptic medication.
What should I do if I notice a change in my seizures after starting phenytoin?
When you first begin a new epilepsy treatment, such as phenytoin, you might notice a change in the number or type of seizures you experience. Your doctor will provide you with advice regarding this. It's important to discuss any changes with them during your regular appointments.
What are the common side-effects of phenytoin and when should I be concerned?
Common side-effects can include feeling sick or being sick, constipation, dizziness or sleepiness, headache, and skin rash. Many of these often improve as your body gets used to the medicine. However, you should speak with your doctor or pharmacist if any of these continue or become troublesome. It's especially important to tell your doctor straight away if you develop a rash, even a mild one, or if you experience a high temperature, sore throat, swollen glands, severe skin rash, mouth ulcers, or unexplained bruising or bleeding, as these could indicate more serious issues.
Is it safe to drink alcohol while taking phenytoin?
If you drink alcohol, you should ask your doctor for advice. Your doctor might recommend that you do not drink alcohol while taking phenytoin because it can change the amount of phenytoin in your body.
If I am pregnant or planning to get pregnant, can I still take phenytoin?
It is very important to tell your doctor if you are pregnant, trying for a baby, or breastfeeding. Many antiepileptic medicines can harm an unborn child. If you are a woman, you should discuss suitable contraception methods with your doctor, as phenytoin can make oral contraceptives less effective. If you plan to have a family, speak with your doctor so they can provide specialist advice before you become pregnant.
What should I do if I forget to take a dose of phenytoin?
If you forget to take a dose, you should take it as soon as you remember. However, if it's almost time for your next dose when you remember, then you should skip the missed dose and just take your next dose as scheduled. Do not take two doses together to try and make up for a forgotten dose.
Why do I need blood tests while taking phenytoin?
You will need to have blood tests from time to time as part of your treatment with phenytoin. These tests allow your doctor to check on your progress and ensure the medication is working safely and effectively for you.
Leitura adicional e referências
- Manufacturer's PIL, Phenytoin sodium 100 mg film-coated tablets; Aurobindo Pharma - Milpharm Ltd, The electronic Medicines Compendium. Dated September 2022.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão prevista para: 1 Jan 2027
2 Jan 2024 | Última versão

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