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Co-phenotrope tablets for diarrhoea

The usual dose for acute diarrhoea in an adult is four tablets to start with, followed by two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.

When you have diarrhoea it is important that you have lots of water to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Eat as normally as possible, as soon as you feel able.

If your symptoms continue for more than 48 hours, speak with a doctor for advice if you have not already done so.

Co-phenotrope must not be taken by children under 16 years of age unless prescribed by a doctor.

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About co-phenotrope

Tipo de medicamento

An antimotility medicine

Usado para

Diarreia

Também chamado de

Diphenoxylate hydrochloride with atropine sulfate

Disponível como

Comprimidos

Co-phenotrope is used in acute diarrhoea (this is diarrhoea which starts suddenly and lasts less than two weeks). It contains two ingredients: diphenoxylate hydrochloride and atropine sulfate. It is the diphenoxylate hydrochloride which is the main ingredient.

The most common cause of acute diarrhoea is infection. Other causes include drinking lots of beer, as a side-effect from other medicines, and anxiety. In most cases the diarrhoea settles within a few days, although it may take longer in some people. The main treatment is to have lots to drink to prevent lack of fluid in the body (dehydration). Antidiarrhoeal medicines like co-phenotrope may not be necessary; however, if you wish to reduce the number of trips that you need to make to the toilet, it can be useful. Most people only need to take it for a few days.

Diphenoxylate works by slowing down the activity of your bowel. This reduces the speed at which the contents pass through, and so food remains in your intestines for longer. This allows more water to be absorbed back into your body and results in firmer stools that are passed less often.

Because co-phenotrope regulates the passage of food through the digestive system, the tablets are also prescribed to help people regulate their bowel activity following surgery on the intestines.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-phenotrope it is important that your doctor or pharmacist knows:

  • Se você está grávida ou amamentando.

  • If you have any problems with the way your liver works, or the way your kidneys work.

  • Se você tiver algum problema respiratório, como asma ou doença pulmonar obstrutiva crônica (DPOC).

  • Se você tiver problemas de próstata ou qualquer dificuldade para urinar.

  • Se lhe foi dito que você tem pressão arterial baixa.

  • Se você tiver algum problema com sua tireoide ou glândulas suprarrenais.

  • Se você tem epilepsia.

  • If you have a problem in your bile duct.

  • If you have a bowel obstruction or an inflammatory bowel problem.

  • Se você tem uma condição que causa fraqueza muscular, chamada miastenia gravis.

  • If you have ever had a drug addiction.

  • Se você já teve uma reação alérgica a um medicamento.

  • Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.

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  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about the tablets and a full list of the side-effects which you may experience from taking them.

  • Start by taking four tablets, and then take a further two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.

  • Co-phenotrope should not be taken by a child under 16 years of age unless it is on the advice of a doctor. If your child has been prescribed co-phenotrope, check the label carefully to make sure you know what dose to give, as the dose will depend upon your child's age.

  • If you forget to take a dose, do not worry, just take a dose after the next time you pass some diarrhoea. Do not take two doses together to make up for a missed dose.

  • It is important that you have lots to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Drinking plain water is ideal, but juice and/or soup are also suitable. Try to avoid drinks that contain a lot of sugar, such as cola or pop, as they can sometimes make diarrhoea worse.

  • Oral rehydration salts can be taken to help prevent dehydration and replace lost salts. These are especially recommended for children and for people who are frail or who have underlying health problems. You can buy these from a pharmacy.

  • Eat small, light meals as soon as you are able. Plain foods such as wholemeal bread and rice are good foods to try eating first.

  • If your symptoms continue for more than 48 hours, speak with a doctor or pharmacist for advice if you have not already done so.

  • If your symptoms get worse, or if you develop a high temperature, or if you pass blood in the diarrhoea, you should ask your doctor or pharmacist for advice as soon as possible.

  • If you buy any medicines check with a pharmacist that they are suitable to take with co-phenotrope. This is because the risk of side-effects can be increased when co-phenotrope tablets are taken with some other medicines.

  • Do not take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, or that a child has taken it by accident, go to the accident and emergency department of your local hospital straightaway. Take the container with you, even if it is empty.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with co-phenotrope. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Co-phenotrope side-effects

O que posso fazer se passar por isso?

Feeling tired, sleepy or dizzy

Se isso acontecer, não dirija e não use ferramentas ou máquinas até se sentir melhor

Dor de cabeça

Beba bastante água e peça ao seu farmacêutico para recomendar um analgésico adequado. Se as dores de cabeça continuarem, informe o seu médico

Tummy (abdominal) discomfort, feeling sick (nausea)

Try taking the tablets after eating some food if you are not already doing so

Constipação

Stop taking co-phenotrope

Feeling confused or restless, mood changes, high temperature (fever), dry mouth, difficulty passing urine, feeling flushed

These should soon pass. If any become troublesome, stop taking co-phenotrope

Se você apresentar outros sintomas que acha que podem ser causados pelo medicamento, consulte seu médico ou farmacêutico.

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

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Leitura adicional e referências

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About the author

Author image

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

About the reviewer

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Sid Dajani

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • Próxima revisão prevista: 26 Abr 2026
  • 27 Abr 2023 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani
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