Can I take Vitamin B2 and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known negative interaction between vitamin B2 (riboflavin) and vitamin D. In fact, they are often taken together in multivitamin supplements.
Why this happens
Vitamin B2 and vitamin D are processed by the body through different pathways. Vitamin B2 is water-soluble and primarily excreted through urine, while vitamin D is fat-soluble and stored in the body's fatty tissues and liver. They do not compete for absorption or interfere with how the other works.
What you should do
It is safe to take vitamin B2 and vitamin D together. Always follow the dosage instructions on the product packaging or those provided by your healthcare professional. Taking vitamin D with a meal containing some fat can help your body absorb it better.
Important precautions
Hypercalcaemia (high blood calcium)
Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking Vitamin B2. Alcohol can interfere with the way your body absorbs this vitamin from the digestive tract, making the supplement less effective.
High-fat meals
Vitamin D is fat-soluble. It is best absorbed when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy). Taking it on an empty stomach may reduce how much your body absorbs.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Magnesium and Wegovy flextouch together?
There is no known direct interaction between magnesium supplements and Wegovy (semaglutide). However, both can affect your digestive system. Wegovy slows down how quickly your stomach empties, which could theoretically change how quickly your body absorbs magnesium, though this is rarely a clinical concern. Additionally, both can cause side effects like nausea or changes in bowel habits (magnesium often softens stools, while Wegovy can cause constipation or diarrhoea).

Drug interactions checker
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Alogliptin and Fibre supplements together?
- Can I take Aspirin and Atorvastatin together?
- Can I take Aspirin and Spironolactone together?
- Can I take Atenolol and Ramipril together?
- Can I take Atorvastatin and Ezetimibe together?
- Can I take Black cohosh and Vitamin B12 together?
- Can I take Chaga and Royal sun together?
- Can I take Cordyceps and Reishi together?
- Can I take Esomeprazole and Trazodone together?
- Can I take Fluanxol and Sedoxil together?
- Can I take Fluoxetine and Paracetamol together?
- Can I take Folic acid and Vitamin C together?
- Can I take Glucosamine and Vitamin B12 together?
- Can I take Indapamide and Magnesium together?
- Can I take Lercanidipine and Promethazine together?
- Can I take Losartan and Trazodone together?
- Can I take Magnesium and St John's wort together?
- Can I take Naproxen and Quinine together?
- Can I take Pregabalin and Venlafaxine together?
- Can I take Solifenacin and Vitamin C together?