Can I take Co-codamol and Mirtazapine together?

Por que isso acontece

Both medicines affect the central nervous system (the brain). Co-codamol contains codeine (an opioid) and mirtazapine is an antidepressant; both have sedative effects. When taken together, these effects add up (an 'additive effect'), making the side effects of both drugs much stronger.

You may be experiencing an interaction between co-codamol (codeine and paracetamol) and mirtazapine if:

• You feel excessively sleepy, drowsy, or sedated.

• You experience dizziness, confusion, or difficulty concentrating.

• You notice slowed breathing or shallow breathing.

• You have poor coordination or balance, increasing the risk of falls.

• You develop constipation or difficulty passing urine.

• Symptoms start soon after taking both medicines together or after a dose increase.

Use this combination with caution. Do not drive, operate machinery, or perform tasks that require you to be alert until you know how these medicines affect you. Avoid drinking alcohol, as this will make the sleepiness much worse. If you feel extremely drowsy or have difficulty breathing, seek medical help immediately.

Se você tiver algum dos sintomas acima, você deve:

• Contact your GP or pharmacist for advice as soon as possible.

• Do not stop mirtazapine or co-codamol suddenly unless advised by a healthcare professional.

• Seek urgent medical help if you experience slowed breathing, severe drowsiness, or confusion.

• Avoid driving or operating machinery until you know how the combination affects you.

• Informe o seu profissional de saúde sobre todos os outros medicamentos e suplementos que você está tomando.

Suicidal thoughts or worsening depression

Mirtazapine can occasionally cause an increase in suicidal thoughts or self-harm, particularly when first starting treatment or changing the dose. Seek immediate medical help if your mood worsens or you have distressing thoughts.

Agranulocitose (contagem baixa de glóbulos brancos)

Mirtazapine can rarely cause a serious drop in white blood cells. You must contact a doctor immediately if you develop signs of infection, such as a high temperature, sore throat, or mouth ulcers.

Paracetamol overdose

Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.

Opioid addiction and withdrawal

Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.

Breathing difficulties

Do not take co-codamol if you have severe asthma or breathing problems, as the codeine can dangerously slow your breathing.

Álcool

You must avoid or strictly limit alcohol while taking these medicines. Both co-codamol and mirtazapine cause drowsiness and slow your reactions. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and an increased risk of falls or accidents.

Cafeína

While there is no direct 'danger' interaction, mirtazapine can sometimes cause increased appetite or weight gain. Additionally, if you are taking mirtazapine for anxiety or sleep, high amounts of caffeine may counteract the calming effects of the medicine. Some branded versions of co-codamol may already contain caffeine; check the packaging to avoid excessive intake which can cause jitters or heart palpitations.

Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.