Can I take Co-codamol and Clopidogrel together?
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Publicado originalmente 25 Jan 2026
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Taking co-codamol (which contains codeine) alongside clopidogrel may make the clopidogrel less effective at preventing blood clots. This could potentially increase your risk of having a heart attack or stroke.
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Por que isso acontece
Clopidogrel needs to be broken down by the body to start working. Codeine (in co-codamol) can slow down the movement of your gut and interfere with how clopidogrel is absorbed and processed, meaning there is less of the active medicine in your bloodstream to thin your blood.
O que você deve fazer
Voltar ao conteúdoYou should speak to your doctor or pharmacist before taking these together. They may suggest an alternative painkiller that does not interfere with your heart medication, such as paracetamol on its own. If you must take both, your doctor may need to monitor you more closely.
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Precauções importantes
Voltar ao conteúdoParacetamol overdose
Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.
Opioid addiction and withdrawal
Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.
Breathing difficulties
Do not take co-codamol if you have severe asthma or breathing problems, as the codeine can dangerously slow your breathing.
Active bleeding
Não tome clopidogrel if you have an active bleeding site, such as a stomach ulcer or bleeding in the brain, as it prevents blood clotting and will worsen the condition.
Upcoming surgery or dental work
You must tell your surgeon or dentist you are taking clopidogrel at least 7 days before any planned procedure, as it increases your risk of bleeding and may need to be stopped temporarily.
Avisos sobre alimentos e bebidas
Voltar ao conteúdoÁlcool
You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage.
It is best to avoid or strictly limit alcohol while taking clopidogrel. Both alcohol and clopidogrel can irritate the stomach lining and increase the risk of internal bleeding, particularly in the stomach and intestines.
Suco de toranja
Grapefruit juice can interfere with how your body processes codeine, potentially making the medicine less effective or increasing the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.
Grapefruit juice can reduce the effectiveness of clopidogrel, making it less likely to prevent blood clots. It is best to avoid drinking grapefruit juice or eating grapefruit while taking this medicine.
Cafeína
Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.
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Usando outros medicamentos
Voltar ao conteúdoTomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.
Aviso Legal
Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.
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Tratamento e medicação
Can I take Co-codamol and Hydroxocobalamin (Vitamin B12) together?
There are no known interactions between co-codamol and hydroxocobalamin. It is generally safe to take these two medications together.

Tratamento e medicação
Can I take Felodipine and Grapefruit together?
Drinking grapefruit juice or eating grapefruit while taking felodipine can significantly increase the amount of the medicine in your bloodstream. This can lead to a sudden drop in blood pressure, a faster heart rate, and increased side effects like flushing, headaches, or swollen ankles.
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Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
25 Jan 2026 | Publicado originalmente

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