Can I take Cannabis and Paracetamol together?

Why this happens

Paracetamol and the main compounds in cannabis (THC and CBD) are processed by different pathways in the liver. They do not significantly interfere with how the body absorbs, breaks down, or removes each other. Additionally, they work on different systems in the body to relieve pain, so they do not typically cause dangerous additive side effects.

You can take paracetamol while using cannabis, but always stick to the recommended dose of paracetamol (usually no more than 4g or eight 500mg tablets in 24 hours). If you are using cannabis for medicinal purposes, it is best to inform your doctor or pharmacist so they can monitor your overall pain management plan.

Liver disease or heavy alcohol consumption

Paracetamol is processed by the liver. If you have liver problems or drink large amounts of alcohol, you are at a much higher risk of fatal liver damage even at standard doses. Never exceed the maximum dose of 4g (8 x 500mg tablets) in 24 hours.

Psychosis or Schizophrenia

You must not use cannabis if you have a personal or strong family history of schizophrenia or other psychotic disorders, as it can trigger or worsen these conditions.

Driving and operating machinery

It is an offence to drive if your ability is impaired by cannabis. Even if you do not feel 'high', the drug stays in your system and can result in a drug-driving conviction.

Alcohol

Drinking alcohol while using cannabis can significantly increase the sedative effects, leading to extreme drowsiness, dizziness, and impaired coordination. It may also increase the levels of THC in your blood, making the 'high' more intense or unpredictable.

You should avoid drinking large amounts of alcohol while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take paracetamol, even at recommended doses. It is safest to stick to moderate drinking or avoid alcohol entirely during treatment.

Grapefruit juice

Grapefruit and grapefruit juice can interfere with how your body breaks down certain compounds in cannabis (particularly CBD). This can lead to higher levels of the medicine in your system, potentially increasing side effects.

Fatty meals

If you are taking cannabis in oral forms (like oils or capsules), eating a high-fat meal can significantly increase the amount of the drug absorbed into your system. This can make the effects much stronger than usual. It is best to be consistent with how you take it in relation to food.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.