Can I take Amitriptyline and Zopiclone together?

You should only take these two medicines together if your doctor is specifically aware you are using both and has told you to do so.

Tomar amitriptilina e zopiclone together can make you feel extremely drowsy, dizzy, and confused.

Por que isso acontece

Both medicines work by slowing down the activity in your central nervous system (your brain and nerves).

Amitriptyline is a em baixa dose with sedative properties, and zopiclone is a 'Z-drug' used for sleep.

When used together, their sedative effects add up (an additive effect), making the overall impact much stronger than taking either medicine alone.

You may be experiencing an interaction between amitriptyline and zopiclone if:

• You feel excessively sleepy, drowsy, or sedated during the day.

• You experience confusion, dizziness, or difficulty concentrating.

• You notice trouble with coordination or balance, increasing the risk of falls.

• You have memory problems or unusual behaviour.

• Breathing becomes slower or shallower than usual, especially at night.

• Symptoms appear shortly after taking both medicines together.
  

Se você tiver algum dos sintomas acima, você deve:

• Speak to your GP or pharmacist for advice on safe use and dosing.

• Do not stop amitriptyline or zopiclone suddenly unless instructed by a healthcare professional.

• Seek urgent medical help if you experience severe drowsiness, breathing difficulties, or confusion.

• Avoid driving or operating machinery until you know how the combination affects you.

• Informe o seu profissional de saúde sobre todos os outros medicamentos e suplementos que você está tomando.

If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or drink any alcohol while using this combination. If you feel excessively sleepy the next day or have trouble breathing, contact your doctor immediately.

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Drowsiness and coordination

Both medicines cause significant drowsiness and impaired coordination. This effect is much stronger when they are taken together, significantly increasing the risk of falls and accidents. Do not drive or operate machinery until you know how they affect you.

Complex sleep behaviours

Zopiclone can cause you to get out of bed while not fully awake and do activities you do not remember (such as sleep-walking, driving, or preparing food). Stop taking it immediately if this happens.

Heart rhythm disorders

Amitriptyline can affect your heart rhythm. It must be used with extreme caution if you have a history of heart disease, particularly a recent heart attack or an irregular heartbeat (arrhythmia).

Álcool

You must avoid or strictly limit alcohol while taking these medicines. Both amitriptyline and zopiclone cause drowsiness and slow your reactions. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and an increased risk of falls or accidents.

Caffeine (Coffee, tea, energy drinks)

Caffeine is a stimulant that works against the sedative effects of zopiclone. Consuming caffeine, especially in the evening, can make zopiclone less effective at helping you sleep.

Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.