Can I take Allopurinol and Co-amoxiclav together?

It is generally considered safe to take alopurinol e co-amoxiclav together, but caution is advised as taking them together increases the risk of developing a rash.

If you notice any new skin rash, redness, or itching, contact your doctor immediately. If you develop a rash along with a fever or swelling of the face, seek urgent medical help.

Por que isso acontece

The exact reason isn't fully understood, but allopurinol seems to make the immune system more sensitive to penicillin-type antibiotics like co-amoxiclav. This makes an allergic-style skin reaction more likely to happen.

You may be experiencing an interaction between allopurinol and co-amoxiclav if:

• You develop skin rashes, itching, or hives.

• You experience fever, chills, or flu-like symptoms.

• You notice unusual bruising or bleeding.

• You feel tired, weak, or generally unwell.

• You have swelling of the face, lips, or throat, which may indicate an allergic reaction.

• Os sintomas aparecem logo após iniciar ou aumentar a dose de qualquer um dos medicamentos.

If you have any of the above symptoms, you should:

• Stop taking the medicines and seek advice from your GP or pharmacist immediately.

• Seek urgent medical help if you develop swelling of the face, lips, or throat, or have difficulty breathing.

• Do not restart the medicines until a healthcare professional confirms it is safe.

• Informe o seu profissional de saúde sobre todos os outros medicamentos e suplementos que você está tomando.

• Attend any blood tests or monitoring recommended to check for allergic reactions or other side effects.

Severe skin rash

Stop taking allopurinol immediately and seek urgent medical advice if you develop a skin rash, peeling skin, or sores on your lips or mouth. This can be a sign of a rare but life-threatening allergic reaction.

Penicillin allergy

Do not take co-amoxiclav if you have ever had a severe allergic reaction (such as anafilaxia or a skin rash) to penicillin or any other 'beta-lactam' antibiotic, as this can be fatal.

Liver problems (jaundice)

Seek medical advice if you develop yellowing of the skin or eyes (jaundice) or dark pee (urine). Co-amoxiclav can cause liver inflammation, which may sometimes occur even after you have finished the course.

Álcool

Alcohol can increase the levels of uric acid in your blood, which makes allopurinol less effective at preventing gout attacks. It is best to limit or avoid alcohol, especially beer and spirits.

Cafeína

High intake of caffeine may interfere with how allopurinol works to lower uric acid. Try to maintain a consistent, moderate intake rather than consuming very large amounts.

Water/fluids

While not a negative interaction, it is vital to drink plenty of fluids (2 to 3 litres a day) while taking allopurinol to help prevent kidney stones.

Food (general)

To reduce the chance of feeling sick or having stomach upset, it is recommended to take co-amoxiclav at the start of a meal.

Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.