RUNX1 partner transcriptional co-repressor 1
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A RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Normal function
A RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Conditions referring to this gene or chromosome
Other names
acute myelogenous leukemia 1 translocation 1, cyclin-D related
AML1T1
CBFA2T1
CDR
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related
eight twenty one protein
ETO
MTG8
MTG8_HUMAN
myeloid translocation gene on 8q22
protein CBFA2T1
runt related transcription factor 1; translocated to, 1 (cyclin D related)
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
zinc finger MYND domain-containing protein 2
ZMYND2
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Leitura adicional e referências
- RUNX1 partner transcriptional co-repressor 1; MedlinePlus, National Library of Medicine.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. Mol Cell Biol. 2009 May;29(10):2644-57. doi: 10.1128/MCB.00073-09. Epub 2009 Mar 16.
- Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 1;17(3):1120-39. doi: 10.2741/3977.
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