RUNX family transcription factor 1
Última atualização 8 Sept 2025
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. Together, these proteins form one version of a complex known as core binding factor (CBF). The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). In particular, it plays an important role in development of hematopoietic stem cells, early blood cells that have the potential to develop into all types of mature blood cells such as white blood cells, red blood cells, and platelets.
Normal function
A RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. Together, these proteins form one version of a complex known as core binding factor (CBF). The RUNX1 protein turns on (activates) genes that help control the development of blood cells (hematopoiesis). In particular, it plays an important role in development of hematopoietic stem cells, early blood cells that have the potential to develop into all types of mature blood cells such as white blood cells, red blood cells, and platelets.
Conditions referring to this gene or chromosome
Other names
acute myeloid leukemia 1 protein
AML1
AMLCR1
CBF-alpha-2
CBFA2
core-binding factor, runt domain, alpha subunit 2
oncogene AML-1
runt-related transcription factor 1
RUNX1_HUMAN
Related patient information and medicines
Patient information leaflet
Contratura de Dupuytren
This forms into... The abnormal tissue that forms is similar to scar tissue that forms following a wound. The reason why this tissue becomes thickened is not known. There seems to be a genetic factor as it has a tendency para corrida in families, so there may be a family history. It is more common in some countries - mainly Northern European. It is more.
Patient information leaflet
Leucemia linfoblástica aguda
This is done in a similar way to a lumbar puncture (described above) and is called an intrathecal injection. In some cases, radiotherapy to the brain is also used. Stem cell transplantation (SCT) SCT - sometimes called bone marrow transplantation - may be performed. It may be used for cases where the leukaemia has come back (recurred) following.
Patient information leaflet
Hemofilia
Hemofilia is a condition where there is a deficiency de clotting factors, so people with this condition usually have prolonged bleeding. There is no cure but with available treatments most people with haemophilia are able to live normal lives. What is haemophilia. Haemophilia is a rare bleeding disorder caused by deficiency of clotting factors..
Patient information leaflet
Fatos e fatores de risco do câncer de mama
Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. If your risk is moderate or high then, if you wish, you may ... Para detalhes of the factors used to assess the risk, see the website of the National Institute for Health and Care Excellence (NICE).
Patient information leaflet
Deficiência de alfa-1 antitripsina
A... This can show which variation of the A1AT faulty gene a person has. It can therefore show how severely affected they are likely to be. Because A1AT deficiency runs in families, se a person is found to have A1AT deficiency, other family members should also be tested. Various other tests may be suggested to determine how severely a person is.
Patient information leaflet
Síndrome do ovário policístico
Síndrome dos ovários policísticos (SOP) é a metabolic condition that affects how the ovaries work. It can cause symptoms such as weight gain, excess hair growth, period problems, and can impact fertility. What is polycystic ovary syndrome (PCOS). Polycystic ovary syndrome (PCOS) is a medical condition that affects how the body regulates hormones. It can.
Leitura adicional e referências
- RUNX family transcription factor 1; MedlinePlus, National Library of Medicine.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC. Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. J Clin Invest. 2013 Sep;123(9):3876-88. doi: 10.1172/JCI68557. Epub 2013 Aug 27.
- Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001 Feb 15;20(4):723-33. doi: 10.1093/emboj/20.4.723.
- Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 1;17(3):1120-39. doi: 10.2741/3977.
- Ran D, Shia WJ, Lo MC, Fan JB, Knorr DA, Ferrell PI, Ye Z, Yan M, Cheng L, Kaufman DS, Zhang DE. RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood. 2013 Apr 11;121(15):2882-90. doi: 10.1182/blood-2012-08-451641. Epub 2013 Jan 31.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.