RAB3 GTPase activating non-catalytic protein subunit 2

Normal function

A RAB3GAP2 gene provides instructions for making a protein that helps regulate the activity of specialized proteins called GTPases, which control a variety of functions in cells. To perform its function, the RAB3GAP2 protein interacts with another protein called RAB3GAP1 (produced from the RAB3GAP1 gene) to form the RAB3GAP complex.

Often referred to as molecular switches, GTPases can be turned on and off. They are turned on (active) when they are attached (bound) to a molecule called GTP and are turned off (inactive) when they are bound to another molecule called GDP. The RAB3GAP complex turns on a GTPase known as RAB18 by exchanging GTP for the attached GDP. When active, RAB18 is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. RAB18 regulates the movement of substances between compartments in cells and the storage and release of fats (lipids) by structures called lipid droplets. The protein also appears to play a role in a process called autophagy, which helps clear unneeded materials from cells. RAB18 is important for the organisation of a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.

The RAB3GAP complex is also thought to inactivate another GTPase known as RAB3 by stimulating a reaction that turns the attached GTP into GDP. RAB3 plays a role in the release of hormones and brain chemicals (neurotransmitters) from cells.

Conditions referring to this gene or chromosome

• Coloboma

• RAB18 deficiency

Other names

DKFZP434D245

KIAA0839

p150

RAB3 GTPase activating protein subunit 2 (non-catalytic)

rab3 GTPase-activating protein 150 kDa subunit

rab3 GTPase-activating protein non-catalytic subunit

rab3-GAP p150

rab3-GAP regulatory subunit

RAB3-GAP150

RAB3GAP150

RGAP-iso

SPG69

WARBM2