isocitrate dehydrogenase (NADP(+)) 2
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A IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. This enzyme is found in mitochondria, which are the energy-producing centers within cells. Within mitochondria, the enzyme participates in reactions that produce energy for cell activities. Specifically, isocitrate dehydrogenase 2 normally converts a compound called isocitrate to another compound called 2-ketoglutarate. A series of additional enzymes further process 2-ketoglutarate to produce energy. The conversion reaction also produces a molecule called NADPH, which is necessary for many cellular processes and helps protect cells from potentially harmful molecules called reactive oxygen species.
Normal function
A IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. This enzyme is found in mitochondria, which are the energy-producing centers within cells. Within mitochondria, the enzyme participates in reactions that produce energy for cell activities. Specifically, isocitrate dehydrogenase 2 normally converts a compound called isocitrate to another compound called 2-ketoglutarate. A series of additional enzymes further process 2-ketoglutarate to produce energy. The conversion reaction also produces a molecule called NADPH, which is necessary for many cellular processes and helps protect cells from potentially harmful molecules called reactive oxygen species.
Conditions referring to this gene or chromosome
Other names
D2HGA2
ICD-M
IDH
IDHM
IDHP_HUMAN
IDP
IDPM
isocitrate dehydrogenase 2 (NADP+), mitochondrial
isocitrate dehydrogenase [NADP], mitochondrial
mNADP-IDH
NADP(+)-specific ICDH
oxalosuccinate decarboxylase
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Leitura adicional e referências
- isocitrate dehydrogenase (NADP(+)) 2; MedlinePlus, National Library of Medicine.
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