forkhead box P3
Última atualização 18 de ago de 2020
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of genes that are involved in regulating the immune system. The immune system normally protects the body from foreign invaders, such as bacteria and viruses, by recognizing and attacking these invaders and clearing them from the body.
Normal function
A FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of genes that are involved in regulating the immune system. The immune system normally protects the body from foreign invaders, such as bacteria and viruses, by recognizing and attacking these invaders and clearing them from the body.
On the basis of its role in controlling gene activity, the FOXP3 protein is called a transcription factor. This protein is essential for the production and normal function of certain immune cells called regulatory T cells, which play an important role in preventing autoimmunity. Autoimmunity occurs when the body attacks its own tissues and organs by mistake. The FOXP3 protein is found primarily in an immune system gland called the thymus, where these regulatory T cells are produced.
Conditions referring to this gene or chromosome
Other names
AIID
DIETER
FOXP3_HUMAN
immune dysregulation, polyendocrinopathy, enteropathy, X-linked
immunodeficiency, polyendocrinopathy, enteropathy, X-linked
IPEX
JM2
MGC141961
MGC141963
PIDX
scurfin
XPID
Related patient information and medicines
Patient information leaflet
Tuberculose
The death rate from TB is falling but it still causes about two million deaths per year worldwide. The main risk factors for TB in the developing world are: Poor nutrition. Poor housing. Poor general health. Environment and poverty: rates of TB are higher among homeless people, prisoners, in large cities and in more deprived areas. A poor immune.
Patient information leaflet
Blefaroespasmo
Why is my eyelid twitching. Primary blepharospasm, or benign essential blepharospasm (BEB), is a term used for eyelid twitching, fluttering or blinking without a known underlying cause. Blefaroespasmo is thought to be due to abnormal functioning do basal ganglia, a pair of 'junction boxes' in the brain that help coordinate our movements. What.
Patient information leaflet
Epiglotite
Epiglotite is the term used to describe inflammation and swelling of the epiglottis which lies just behind the root of the tongue. It is usually caused by infection with a bacteria. The usual symptoms are a severe sore throat, pain or difficulty swallowing and a high temperature (fever). Breathing difficulties can occur. Prompt treatment is.
Patient information leaflet
Pemfigo vulgar
A skin specialist should supervise trea... What is pemphigus vulgaris. Pemphigus vulgaris is a rare skin condition that causes blisters. It is a serious disease that needs treatment. If it is not treated, it is often fatal. These different conditions vary greatly in their seriousness, outlook (prognosis) and treatment. Pemphigus vulgaris is the.
Patient information leaflet
Hematoma subdural
There are also three thin spaces between the layers of meninges: The epidural space is the space between the vertebral column and the dura mater. (There is only a potential epidural space in the skull.). ... What is a subdural haematoma and what causes it. A subdural haematoma is a collection of clotting blood that forms in the subdural space. It.
Patient information leaflet
Hérnia de hiato
Acid reflux symptoms Symptoms de refluxo ácido (gastro-oesophageal reflux disease or GORD) include: Heartburn: this is the main symptom. This is a burning feeling which rises from the upper tummy (abdomen) or lower chest up towards the neck. Pain in the upper abdomen and chest. Feeling sick. An acid taste in the mouth. Bloating. Belching. Difficulty.
Leitura adicional e referências
- forkhead box P3; MedlinePlus, National Library of Medicine.
- Bacchetta R, Passerini L, Gambineri E, Dai M, Allan SE, Perroni L, Dagna-Bricarelli F, Sartirana C, Matthes-Martin S, Lawitschka A, Azzari C, Ziegler SF, Levings MK, Roncarolo MG. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest. 2006 Jun;116(6):1713-22. doi: 10.1172/JCI25112.
- Bin Dhuban K, Piccirillo CA. The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Curr Opin Allergy Clin Immunol. 2015 Dec;15(6):525-32. doi: 10.1097/ACI.0000000000000214.
- Fuchizawa T, Adachi Y, Ito Y, Higashiyama H, Kanegane H, Futatani T, Kobayashi I, Kamachi Y, Sakamoto T, Tsuge I, Tanaka H, Banham AH, Ochs HD, Miyawaki T. Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations. Clin Immunol. 2007 Dec;125(3):237-46. doi: 10.1016/j.clim.2007.08.004. Epub 2007 Oct 3.
- Nik Tavakoli N, Hambly BD, Sullivan DR, Bao S. Forkhead box protein 3: essential immune regulatory role. Int J Biochem Cell Biol. 2008;40(11):2369-73. doi: 10.1016/j.biocel.2007.10.004. Epub 2007 Oct 10.
- Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaizumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs HD, Miyawaki T. Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Clin Immunol. 2011 Oct;141(1):111-20. doi: 10.1016/j.clim.2011.06.006. Epub 2011 Jul 12.
- Tan QKG, Louie RJ, Sleasman JW. IPEX Syndrome. 2004 Oct 19 [updated 2024 Feb 1]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1118/
- Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007 Oct;120(4):744-50; quiz 751-2. doi: 10.1016/j.jaci.2007.08.044.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.