DCC netrin 1 receptor
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The DCC gene provides instructions for making a protein called the netrin-1 receptor, which is involved in the development of the nervous system. This protein attaches (binds) to a protein called netrin-1, and these two proteins fit together like a lock and key. The binding of netrin-1 to its receptor helps direct the growth of specialized nerve cell extensions called axons. Axons transmit nerve impulses that can signal muscle movement.
Normal function
The DCC gene provides instructions for making a protein called the netrin-1 receptor, which is involved in the development of the nervous system. This protein attaches (binds) to a protein called netrin-1, and these two proteins fit together like a lock and key. The binding of netrin-1 to its receptor helps direct the growth of specialized nerve cell extensions called axons. Axons transmit nerve impulses that can signal muscle movement.
When the brain sends a signal to trigger muscle movement, the signal usually travels from one half of the brain to the opposite side of the body. The binding of netrin-1 to its receptor allows axons to develop this signaling pathway.
The netrin-1 receptor is also thought to act as a dependence receptor, which means it functions differently depending on whether or not it is bound to its protein. When the netrin-1 receptor is bound to netrin-1, it plays a role in nervous system development. When it is not bound to netrin-1, the netrin-1 receptor acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. When the netrin-1 receptor is acting as a tumour suppressor, studies suggest that the netrin-1 receptor triggers the self-destruction of cells when they are no longer needed (apoptosis).
Conditions referring to this gene or chromosome
Other names
CRC18
CRCR1
DCC_HUMAN
IGDCC1
MRMV1
netrin receptor DCC
NTN1R1
tumour suppressor protein DCC
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Leitura adicional e referências
- DCC netrin 1 receptor; MedlinePlus, National Library of Medicine.
- Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer. 2004 Dec;4(12):978-87. doi: 10.1038/nrc1504.
- Depienne C, Cincotta M, Billot S, Bouteiller D, Groppa S, Brochard V, Flamand C, Hubsch C, Meunier S, Giovannelli F, Klebe S, Corvol JC, Vidailhet M, Brice A, Roze E. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology. 2011 Jan 18;76(3):260-4. doi: 10.1212/WNL.0b013e318207b1e0.
- Franz EA, Chiaroni-Clarke R, Woodrow S, Glendining KA, Jasoni CL, Robertson SP, Gardner RJM, Markie D. Congenital mirror movements: phenotypes associated with DCC and RAD51 mutations. J Neurol Sci. 2015 Apr 15;351(1-2):140-145. doi: 10.1016/j.jns.2015.03.006. Epub 2015 Mar 10.
- Gallea C, Popa T, Billot S, Meneret A, Depienne C, Roze E. Congenital mirror movements: a clue to understanding bimanual motor control. J Neurol. 2011 Nov;258(11):1911-9. doi: 10.1007/s00415-011-6107-9. Epub 2011 Jun 3.
- Mehlen P, Llambi F. Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer. 2005 Jul 11;93(1):1-6. doi: 10.1038/sj.bjc.6602656.
- Meneret A, Depienne C, Riant F, Trouillard O, Bouteiller D, Cincotta M, Bitoun P, Wickert J, Lagroua I, Westenberger A, Borgheresi A, Doummar D, Romano M, Rossi S, Defebvre L, De Meirleir L, Espay AJ, Fiori S, Klebe S, Quelin C, Rudnik-Schoneborn S, Plessis G, Dale RC, Sklower Brooks S, Dziezyc K, Pollak P, Golmard JL, Vidailhet M, Brice A, Roze E. Congenital mirror movements: mutational analysis of RAD51 and DCC in 26 cases. Neurology. 2014 Jun 3;82(22):1999-2002. doi: 10.1212/WNL.0000000000000477. Epub 2014 May 7.
- Meneret A, Trouillard O, Dunoyer M, Depienne C, Roze E. Congenital Mirror Movements. 2015 Mar 12 [updated 2020 Sep 24]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK279760/
- Peng J, Charron F. Lateralization of motor control in the human nervous system: genetics of mirror movements. Curr Opin Neurobiol. 2013 Feb;23(1):109-18. doi: 10.1016/j.conb.2012.08.007. Epub 2012 Sep 16.
- Srour M, Riviere JB, Pham JM, Dube MP, Girard S, Morin S, Dion PA, Asselin G, Rochefort D, Hince P, Diab S, Sharafaddinzadeh N, Chouinard S, Theoret H, Charron F, Rouleau GA. Mutations in DCC cause congenital mirror movements. Science. 2010 Apr 30;328(5978):592. doi: 10.1126/science.1186463.
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