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Gel de isotretinoína para acne

Nota do autor clínico Michael Stewart 20/05/2021: Isotrexin® gel was discontinued in the UK in January 2020. At the time of review there are no skin preparations containing isotretinoin available in the UK. Isotretinoin skin preparations may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.

For information about taking isotretinoin as a capsule please see the medicine leaflet Cápsulas de isotretinoína para acne.

Apply the gel once or twice a day, as directed by your doctor.

Your skin may become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds.

You should avoid getting pregnant. Ask your doctor about suitable contraception.

At a glance

  • Isotretinoin gel is a rub-on medicine used for mild-to-moderate acne.

  • It helps unblock pores and treat blackheads and whiteheads.

  • Do not use this gel if you are pregnant or trying for a baby.

  • Apply a thin layer to affected areas once or twice a day, as directed by your doctor.

  • It can make your skin more sensitive to sunlight, so use sun cream.

  • Skin irritation, redness, burning, or dry skin are common side effects.

  • It can take several weeks to see an improvement in your skin.

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About isotretinoin gel

Tipo de medicamento

A rub-on (topical) retinoid

Usado para

Mild-to-moderate acne

Também chamado de

Isotrex® (discontinued); Isotrexin® (discontinued) (contains isotretinoin and erythromycin)

Disponível como

Gel

Acne is the common cause of spots. Most people with acne are aged between 12 and 25, but some older and younger people are affected too. Small sebaceous glands lie just under your skin surface and make an oil (sebum) that keeps your skin supple and smooth. Tiny pores on your skin allow the sebum to come on to the surface of your skin. In acne, some of these pores become blocked, causing small pimples, blackheads and whiteheads (comedones).

Applying isotretinoin to the areas of your skin with acne will help to unblock pores and treat blackheads or whiteheads. It also has some effect on reducing inflammation. If your spots are inflamed, you may be prescribed a brand called Isotrexin® as this gel also contains an antibacterial agent called erythromycin.

Isotretinoin is also available as capsules for more severe forms of acne which have not got better by using rub-on skin treatments. There is a separate medicine leaflet which contains more information about this, called Cápsulas de isotretinoína para acne.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using isotretinoin gel it is important that your doctor knows:

  • If you are pregnant, trying for a baby or breastfeeding. You must not use isotretinoin gel if you could be pregnant.

  • If you have a skin problem other than acne, such as if you have eczema or rosacea.

  • If you or any close family members have ever had skin cancer.

  • If you are taking or using any other medicines. This includes any creams you are using which are available to buy without a prescription.

  • Se você já teve uma reação alérgica a um medicamento.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about isotretinoin and will provide you with a full list of the side-effects which you may experience from using the gel.

  • Apply isotretinoin gel exactly as your doctor tells you to. It is best if you wash and gently dry the affected areas of your skin before you apply isotretinoin. A general point is that you should apply it to all of the area where your spots occur and not just to each spot. It is usual to apply it once or twice a day at first, although your doctor may suggest you use it less than this once your skin has improved. You only need to apply a thin layer of gel. Remember to wash your hands after you have finished applying the gel.

  • If you have recently been using a preparation for your acne that causes your skin to peel, allow your skin to recover for a few days before you start using isotretinoin gel.

  • Do not use the gel on any areas of your skin which are sunburnt or sore. Also, try to avoid getting it on the sensitive areas of your skin in or around your nostrils, your eyes and your mouth. Try not to let it build up in the folds or creases of your skin.

  • It is recommended that you use a mild soap and lukewarm water to wash with, as very hot or cold water can worsen acne. You cannot clean off blackheads. The black tip of a blackhead is actually a skin pigment and cannot be removed by cleaning or scrubbing.

  • Se sua pele ficar muito seca, pode ajudar usar um creme hidratante (de preferência um creme sem fragrância e à base de água). Não use pomadas ou cremes ricos em óleo, pois podem obstruir novamente seus poros.

  • You can use make-up and moisturisers, but do not apply them at the same time as you use isotretinoin gel. Try to avoid any skin products which exfoliate or dry your skin.

  • Isotretinoin gel can make your skin more sensitive to sunlight than usual. A sun protection cream can help if you are out in the sun on bright days, even if it is cloudy. Do not use sunbeds.

  • It is normal for isotretinoin treatment to take several weeks before there is a noticeable improvement in your skin. The most common reason for treatment failure is stopping treatment too soon thinking it is not working. If there is no improvement despite having used the gel for eight weeks, speak with your doctor again as there are other treatments which could be more suited to your condition.

  • You should avoid getting pregnant while you are using isotretinoin as there is a slight risk of harm to unborn babies. If necessary, discuss with your doctor which types of contraception are suitable for you and your partner.

  • Once your spots have cleared, acne commonly flares up again if you stop treatment. To prevent this, it is usual to carry on with a maintenance treatment after your spots have gone. The dose used to prevent spots from returning is often lower than that used to treat acne. It is common to need maintenance treatment for a number of years to keep acne away.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with isotretinoin gel. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common isotretinoin gel side-effects (these affect more than 1 in 10 people)


O que posso fazer se passar por isso?

Skin irritation, redness, burning, dry or peeling skin

Reduce how often you are using the gel for a few days to see if this settles. If it is severe or troublesome, speak with your doctor

If you experience any other symptoms which you think may be due to isotretinoin, speak with your doctor or pharmacist for further advice.

  • Mantenha todos os medicamentos fora do alcance e da vista das crianças.

  • Armazene em local fresco e seco, longe de calor e luz diretos.

Informações importantes sobre todos os medicamentos

Se você comprar algum medicamento, sempre consulte um farmacêutico para garantir que seja seguro usá-lo com seus outros medicamentos.

This preparation is for external use only. If you suspect that someone has swallowed some of it by accident, contact the accident and emergency department of your local hospital for advice.

Se você for se submeter a uma operação ou tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está usando.

Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.

Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.

Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.

Relatar efeitos colaterais de um medicamento ou vacina

Se você sentir efeitos colaterais, pode relatá-los online através do Yellow Card website.

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Perguntas frequentes

What is the difference between isotretinoin gel and isotretinoin capsules?

Isotretinoin gel is a rub-on skin treatment used for mild-to-moderate acne, helping to unblock pores and reduce inflammation. Isotretinoin capsules are a separate medicine used for more severe forms of acne that haven't responded to topical treatments.

My skin feels very dry since I started using isotretinoin gel. What can I do?

If your skin becomes very dry, you can use a moisturising cream. It's best to choose a fragrance-free and water-based cream. You should avoid rich or oil-based creams and ointments as they might clog your pores again.

How long will it take before I see an improvement in my acne with isotretinoin gel?

It is normal for isotretinoin treatment to take several weeks before you notice an improvement in your skin. It's important not to stop treatment too soon, even if you don't see immediate results.

Can I use make-up while I'm using isotretinoin gel?

Yes, you can use make-up and moisturisers. However, you should not apply them at the same time as you use isotretinoin gel. Also, try to avoid any skin products that exfoliate or dry your skin.

What should I do if I get isotretinoin gel in my eyes or mouth?

You should try to avoid getting the gel on sensitive areas of your skin, such as in or around your nostrils, eyes, and mouth. The article does not specify what to do if accidental contact occurs, but it advises caution during application.

Can I stop using isotretinoin gel once my spots have cleared?

Acne commonly flares up again if you stop treatment once your spots have cleared. To prevent this, it's usual to continue with a maintenance treatment. This ongoing dose is often lower than the initial treatment dose and may be needed for several years to keep acne away.

What kind of soap should I use when washing my face with acne?

It is recommended to use a mild soap and lukewarm water for washing, as very hot or cold water can make acne worse.

Can I use isotretinoin gel if I am planning to get pregnant?

You must not use isotretinoin gel if you could be pregnant or are trying for a baby. There is a slight risk of harm to unborn babies. If necessary, you should discuss suitable contraception options with your doctor.

Leitura adicional e referências

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico

BPharm (Hons), MRPharmS

Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • Próxima revisão prevista para: 22 de maio de 2027
  • 9 Jun 2024 | Última versão

    Última atualização por

    Michael Stewart, MRPharmS

    Revisado por

    Sid Dajani
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