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Can I take Diazepam and Codeine together?

Guia de interação medicamentosa

Taking diazepam and codeine together can cause extreme sleepiness, dizziness, and severe breathing difficulties. In serious cases, this combination can lead to a coma or be life-threatening because it can cause you to stop breathing.

Por que isso acontece

Both medicines are 'central nervous system depressants'. This means they both slow down brain activity and the signals that tell your body to breathe. When taken together, their effects add up, making the impact on your breathing and alertness much stronger than if taken alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you must take both, use the lowest dose possible for the shortest amount of time. Seek emergency medical help immediately if you experience extreme sleepiness, shallow breathing, or difficulty staying awake. Avoid alcohol completely while taking these medicines.

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Combined use with other sedatives or alcohol

Taking these medicines together, or with alcohol, significantly increases the risk of life-threatening breathing problems and extreme sleepiness. Avoid alcohol and do not take other sedating medicines unless specifically directed by your doctor.

Ultra-rapid metabolism (CYP2D6)

Some people turn codeine into morphine much faster than normal. If you experience extreme sleepiness, confusion, or shallow breathing, stop taking the medicine and seek urgent medical help. This is especially dangerous for breastfeeding mothers as it can cause fatal overdose in the baby.

Long-term use and dependence

These medicines are for short-term use only. Taking them for more than a few days can lead to physical addiction and withdrawal symptoms when you stop. Do not increase the dose or take them for longer than prescribed.

Álcool

You must avoid drinking alcohol while taking these medicines. Both diazepam and codeine cause drowsiness and slow down your breathing. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and loss of consciousness.

Suco de toranja

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can stop your body from breaking down diazepam properly. This can lead to higher levels of the medicine in your blood, increasing the risk of side effects like extreme sleepiness and poor coordination.

Caffeine (Coffee, tea, energy drinks)

Caffeine is a stimulant and can have the opposite effect of diazepam, which is a sedative. Consuming high amounts of caffeine may make diazepam less effective at treating anxiety or helping you sleep.

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Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.

Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • 25 Jan 2026 | Publicado originalmente
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