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Can I take Diazepam and Codeine together?

Guia de interação medicamentosa

Taking diazepam and codeine together can cause extreme sleepiness, dizziness, and severe breathing difficulties. In serious cases, this combination can lead to a coma or be life-threatening because it can cause you to stop breathing.

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Por que isso acontece

Both medicines are 'central nervous system depressants'. This means they both slow down brain activity and the signals that tell your body to breathe. When taken together, their effects add up, making the impact on your breathing and alertness much stronger than if taken alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you must take both, use the lowest dose possible for the shortest amount of time. Seek emergency medical help immediately if you experience extreme sleepiness, shallow breathing, or difficulty staying awake. Avoid alcohol completely while taking these medicines.

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Combined use with other sedatives or alcohol

Taking these medicines together, or with alcohol, significantly increases the risk of life-threatening breathing problems and extreme sleepiness. Avoid alcohol and do not take other sedating medicines unless specifically directed by your doctor.

Ultra-rapid metabolism (CYP2D6)

Some people turn codeine into morphine much faster than normal. If you experience extreme sleepiness, confusion, or shallow breathing, stop taking the medicine and seek urgent medical help. This is especially dangerous for breastfeeding mothers as it can cause fatal overdose in the baby.

Long-term use and dependence

These medicines are for short-term use only. Taking them for more than a few days can lead to physical addiction and withdrawal symptoms when you stop. Do not increase the dose or take them for longer than prescribed.

Asthma or breathing problems

Do not take codeine if you have severe asthma or breathing difficulties, as it can dangerously slow down your breathing.

Condução e operação de máquinas

Frequentemente é uma infração dirigir enquanto toma diazepam, pois pode prejudicar seriamente sua coordenação e tempo de reação. Não dirija ou opere máquinas até saber como este medicamento afeta você, e sempre mantenha o medicamento em sua embalagem original para mostrar à polícia se for parado.

Depressão respiratória

Do not take diazepam if you have severe lung disease or breathing difficulties, as it can further slow your breathing to dangerous levels.

Gravidez

Evite o uso na fase final da gravidez ou durante o parto, pois pode causar a síndrome do bebê flácido e sintomas de abstinência potencialmente fatais no recém-nascido.

Álcool

You must avoid drinking alcohol while taking these medicines. Both diazepam and codeine cause drowsiness and slow down your breathing. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and loss of consciousness.

Suco de toranja

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can stop your body from breaking down diazepam properly. This can lead to higher levels of the medicine in your blood, increasing the risk of side effects like extreme sleepiness and poor coordination.

Cafeína (Café, chá, bebidas energéticas)

Caffeine is a stimulant and can have the opposite effect of diazepam, which is a sedative. Consuming high amounts of caffeine may make diazepam less effective at treating anxiety or helping you sleep.

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Taking multiple medicines? Our Verificador de Interações de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.

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Histórico do artigo

As informações nesta página são escritas e revisadas por clínicos qualificados.

  • 25 Jan 2026 | Publicado originalmente
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