Can I take Danazol and Metformin together?

Por que isso acontece

Danazol is a synthetic steroid that can cause 'insulin resistance'. This means it makes your body's cells less responsive to insulin and can increase the amount of sugar your liver produces, which directly opposes the blood-sugar-lowering effects of metformin.

You should monitor your blood sugar levels more frequently than usual. If you notice your readings are consistently high, or if you experience symptoms of high blood sugar (such as feeling very thirsty, needing to urinate more often, or blurred vision), contact your doctor. They may need to adjust your metformin dose while you are taking danazol.

Gravidez

You must not take danazol if you are pregnant or planning to become pregnant. It can cause the development of male physical characteristics in a female fetus. You must use effective, non-hormonal contraception (such as condoms) while taking it.

Blood clots (Thromboembolism)

Danazol significantly increases the risk of serious blood clots. Seek immediate medical help if you experience sudden leg swelling, chest pain, or shortness of breath.

Doença hepática

Danazol can cause serious liver damage and non-cancerous liver tumours. You will need regular blood tests to monitor your liver function while taking this medicine.

Severe infection, dehydration, or high alcohol intake

Stop taking metformin and seek urgent medical help if you develop symptoms of lactic acidosis, such as severe vomiting, stomach ache, muscle cramps, or deep, rapid breathing. This is a rare but serious emergency.

Exames com contraste (por exemplo, tomografia ou raio-X)

Você deve informar ao seu médico que toma metformina se for fazer uma tomografia que envolva uma injeção de 'contraste'. Geralmente, será necessário interromper o uso de metformina 48 horas antes e depois do procedimento para evitar danos aos rins.

Álcool

It is best to avoid or strictly limit alcohol while taking metformin. Drinking alcohol can increase the risk of a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood). It also increases the risk of low blood sugar (hypoglycaemia).

It is best to avoid or strictly limit alcohol while taking danazol. Combining danazol with alcohol can cause you to feel nauseous or short of breath (a disulfiram-like reaction). Additionally, both danazol and alcohol can put strain on your liver, and using them together increases the risk of liver damage.

Absorção de vitamina B12

O uso prolongado de metformina pode impedir que seu corpo absorva quantidade suficiente de vitamina B12 dos alimentos. Você pode precisar fazer um exame para verificar seus níveis de B12 com seu médico ou tomar um suplemento se desenvolver sintomas como fadiga extrema ou uma língua dolorida.

Taking multiple medicines? Our Verificador de Interações de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.