Can I take Bisoprolol and Empagliflozin together?

Why this happens

Both medicines can lower blood pressure: bisoprolol slows the heart rate, while empagliflozin acts as a diuretic (water pill) which reduces fluid in the body. Furthermore, while empagliflozin lowers blood sugar, bisoprolol (a beta-blocker) can interfere with the body's natural response to low sugar and mask symptoms like palpitations.

What you should do

You can usually take these medicines together, but you should monitor your blood pressure and blood sugar levels more closely, especially when starting or changing doses. Be aware that you might not feel the usual 'racing heart' if your sugar drops, so look out for other signs like sweating or hunger. If you feel dizzy, lightheaded, or faint, contact your doctor.

Important precautions

Asthma or chronic obstructive pulmonary disease (COPD)

Bisoprolol can cause your airways to narrow, making it much harder to breathe or triggering a severe asthma attack. It is usually avoided if you have a history of wheezing or asthma.

Diabetes

Bisoprolol can mask the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You will need to monitor your blood sugar more closely.

Diabetic ketoacidosis (DKA)

Empagliflozin can cause a serious condition called ketoacidosis even if your blood sugar levels appear normal. You must seek urgent medical help if you develop nausea, vomiting, stomach pain, or fruity-smelling breath.

Fournier's gangrene (necrotising fasciitis of the perineum) - empagliflozin

Seek immediate medical attention if you experience pain, tenderness, redness, or swelling in the genital or anal area, especially if accompanied by fever or a general feeling of being unwell.

Food and drink warnings

Alcohol

Alcohol can increase the blood pressure-lowering effect of bisoprolol, which may make you feel dizzy, lightheaded, or faint, especially when you first start taking it or when your dose is increased. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.