Can I take Aspirin and Ibuprofen together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking ibuprofen and aspirin together can increase your risk of developing stomach ulcers or internal bleeding. Additionally, if you take aspirin to protect your heart or prevent a stroke, ibuprofen can block aspirin from working properly, potentially leaving your heart unprotected.
Why this happens
Both drugs belong to the same family (NSAIDs). When used together, they have an 'additive' effect on the stomach lining, making damage more likely. Furthermore, ibuprofen physically blocks the spot on your blood cells (platelets) where aspirin needs to attach to thin the blood.
What you should do
Avoid taking ibuprofen if you are on a daily low-dose aspirin regimen for heart health. If you must take both, take the aspirin first and wait at least 30 minutes to 2 hours before taking ibuprofen. Always consult your doctor or pharmacist for safer pain relief alternatives, such as paracetamol.
Important precautions
Asthma
Do not take these medicines if you have asthma that is worsened by aspirin or other NSAIDs, as they can trigger a life-threatening asthma attack.
Stomach ulcers or bleeding
Avoid these medicines if you have a history of stomach ulcers or gastrointestinal bleeding, as they significantly increase the risk of serious internal bleeding and perforation.
Pregnancy (third trimester)
Do not take these medicines during the last 3 months of pregnancy (third trimester) as they can cause serious heart and kidney problems in the unborn baby and complications during delivery.
Food and drink warnings
Alcohol
Drinking alcohol while taking aspirin or ibuprofen increases the risk of irritation to your stomach lining and may lead to stomach bleeding or ulcers. It is best to limit alcohol intake or avoid it altogether while taking these medicines.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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