Can I take Amitriptyline and Trazodone together?

Por que isso acontece

Both drugs increase the levels of a chemical called serotonin in the brain; too much serotonin can lead to toxicity. Additionally, both drugs have sedative effects and can interfere with the electrical signals in the heart (QT prolongation).

You should only take these two medications together if specifically prescribed by a specialist who is monitoring you closely. Seek immediate medical help if you experience a very fast or irregular heartbeat, severe dizziness, fainting, muscle stiffness, tremors, or high fever. Avoid driving or operating machinery until you know how this combination affects you.

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Serotonin Syndrome risk

Do not take these medicines with other antidepressants or St John's Wort. Combining them can cause a life-threatening condition called serotonin syndrome, marked by high fever, agitation, and muscle rigidity.

Heart rhythm disorders (Long QT)

These medicines can affect your heart rhythm. You must inform your doctor if you have a history of heart disease or a slow heart rate, as they can trigger a dangerous irregular heartbeat.

Glaucoma (Acute Angle-Closure)

Amitriptyline can cause a sudden, painful increase in eye pressure. Do not take this medicine if you have a history of glaucoma without specialist advice, and seek immediate help if you experience sudden blurred vision or eye pain.

Álcool

You should avoid or strictly limit alcohol while taking these medicines. Both amitriptyline and trazodone cause drowsiness; alcohol significantly increases this effect, which can impair your coordination, judgment, and breathing. It can also make your depression or anxiety worse.

Caffeine (Coffee, Tea, Energy Drinks)

Amitriptyline can sometimes increase the effects of caffeine, making you feel jittery, anxious, or unable to sleep. Conversely, high amounts of caffeine may reduce the sedative effectiveness of the medicine. Try to keep your caffeine intake consistent and moderate.

Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.