SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
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The SAMHD1 gene provides instructions for making an enzyme that helps cut (cleave) molecules called deoxynucleoside triphosphates (dNTPs) into their deoxynucleoside and triphosphate components. The dNTP molecules are needed for the replication and maintenance of DNA in the body's cells, however; invading viruses such as the human immunodeficiency virus (HIV) also need dNTPs to make copies of themselves. Therefore, the amount of available dNTPs must be tightly controlled. The SAMHD1 enzyme helps regulate the amount of available dNTPs to both meet the needs of the body's cells and control viral infections.
Normal function
The SAMHD1 gene provides instructions for making an enzyme that helps cut (cleave) molecules called deoxynucleoside triphosphates (dNTPs) into their deoxynucleoside and triphosphate components. The dNTP molecules are needed for the replication and maintenance of DNA in the body's cells, however; invading viruses such as the human immunodeficiency virus (HIV) also need dNTPs to make copies of themselves. Therefore, the amount of available dNTPs must be tightly controlled. The SAMHD1 enzyme helps regulate the amount of available dNTPs to both meet the needs of the body's cells and control viral infections.
The SAMHD1 enzyme is also thought to play a role in DNA repair and maintaining the stability of genetic material.
Conditions referring to this gene or chromosome
Other names
DCIP
dendritic cell-derived IFNG-induced protein
monocyte protein 5
MOP-5
SAM domain and HD domain 1
SAM domain and HD domain-containing protein 1
SAMH1_HUMAN
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Leitura adicional e referências
- SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1; MedlinePlus, National Library of Medicine.
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